Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19

[intrepidity]

Last edited Thu Mar 12, 2020, 03:50 PM - Edit history (1)

Has there been a run on chloroquine yet? Forewarned is forearmed........... ??

https://www.ncbi.nlm.nih.gov/m/pubmed/32074550/

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.

Abstract
The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future.

ETA: There are recent posts that question the above. Please see https://www.democraticunderground.com/100213042640

So some additional links:

https://www.sciencedirect.com/science/article/pii/S0166354220301145

https://www.nature.com/articles/d41587-020-00003-1

At least ten clinical trials are testing chloroquine, approved as an antimalarial and autoimmune disease drug. In vitro, the endosomal acidification fusion inhibitor blocked infection of a clinical isolate of SARS-CoV-2.

https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations

[Xipe Totec]

1. Stock up on Tonic water. Gin and Tonics for everyone!

[intrepidity]

2. Not gonna lie. That was my first thought

[2naSalit]

4. I have to wait util

Tuesday when my $$ arrives to go shopping. I'm making my list now though.

[Blueplanet]

6. Quinine is in Tonic water?

Quinine is used to treat malaria - it is an antimalarial drug. Had to look it up.

[Xipe Totec]

17. That's why Gin & Tonic became such a popular British drink in East India. nt

[sl8]

32. Regarding current U.S. tonic water:

From Wikipedia, so take it with a grain of salt (or follow the sources):
https://en.m.wikipedia.org/wiki/Tonic_water

Tonic water

Tonic water (or Indian tonic water) is a carbonated soft drink in which quinine is dissolved. Originally used as a prophylactic against malaria, tonic water usually now has a significantly lower quinine content and is consumed for its distinctive bitter flavor, though it is nowadays also often sweetened. It is often used in mixed drinks, particularly in gin and tonic.

[...]

Quinine content

[...]

In the United States, the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm[3] (83 mg per liter if calculated by mass), while the daily therapeutic dose of quinine is in the range of 500–1000 mg,[4] and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult).[5] It is often recommended as a relief for leg cramps, but medical research suggests some care is needed in monitoring doses.[6] Because of quinine's risks, the FDA cautions consumers against using "off-label" quinine drugs to treat leg cramps.[7]

[...]

[Footnotes:]

3. "21 CFR §172.575 Quinine" (PDF). Retrieved 15 December 2008.

4. "Quinine". Tropical Plant Database. Section "Current practical uses": Raintree Nutrition. Retrieved 10 July 2011.

5. Achan, J (2011). "Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria". Malaria Journal. 10 (144): 1–12. doi:10.1186/1475-2875-10-144. PMC 3121651. PMID 21609473.

[...]

More at link.

[Recursion]

33. The gin & tonic is the only mixed drink where the alcohol was put in to hide the taste of the mixer

Still popular in India

[cwydro]

14. My first thought!

My mom, god rest her, is raising a glass somewhere!

[Laura PourMeADrink]

25. +1

[captain queeg]

3. Shit, I used to have several bottles left over from deployment

Pretty sure I tossed them. Didn’t worry much about malaria in Afghanistan.

[Leghorn21]

5. Hey i, I'M FOLLOWING YOU AROUND it's true

...meanwhile, I did a search a few days back, and found an article that said that licorice root has shown to possess anti-viral properties, hmmm, and vitamins A, C and E are good for our lung health

Thanks and carry on, i!! Keep telling us what you know!!

on edit: here's the link, which of course I can't really read, it's mighty scholarly!:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629407/

[meow2u3]

7. Stock up on Good-N-Plenty

or other licorice items if you can tolerate them. I have no tolerance for table sugar or fructose, so I can't eat them without suffering later.
Question is, are there any sugar free licorice stuff I can pick up?

[sdfernando]

10. You can get licorice root

At many stores....also DGL is good and chewable.

[meow2u3]

42. I picked up some licorice root yesterday

The Vitamin Store carries it, thank God. It costs about $10 for 100 capsules. You might want to go there if you can't find it elsewhere.

[scarletwoman]

12. Be careful about so-called licorice candies - many of them are actually flavored with anise,

and may contain no real licorice at all.

[meow2u3]

15. I'm aware of it

I've seen "licorice flavored" candies and checked the ingredients only to discover the anise flavoring.

[scarletwoman]

18. Oh good. Oddly enough, I'm actually allergic to real licorice, so when I find something

flavored with anise, I know it's safe for me to eat.

[duhneece]

9. Stock up on Stash (brand) Licorice Spice Herbal Tea

Mmmmm. Helps with ulcers and viral infections.

[intrepidity]

21. Lol

Well good day to have done so. Normally you'd be bored out of your mind by my posts.

[Progressive dog]

8. That's a prescription drug

in the USA, probably made in China.

[Leghorn21]

11. Oh, I thought it was OTC, thank you, dog nt

[a la izquierda]

39. Good god no.

And you don’t want to take it unless absolutely necessary. The side effects can be brutal. I’ve had to take it while traveling in Central and South America. I felt like hell.

[Leghorn21]

41. I stand ever so corrected, iz!!

Thank you!

[sinkingfeeling]

13. I still have 7 anti-malaria tablets from my trip to Africa. Mine are

Atovaquone-Proguanl.

[milestogo]

24. That's a much newer drug, and not the same thing.

[Joinfortmill]

16. I'll have mine with vodka and a bit of lime, thank you.

[indigovalley]

19. Is this in all anti-malaria drugs?

Jeez, I have Lupus and take Hydroxychloroquine 200 mg a day. Does that mean I have extra protection against Covid 19?

[Drahthaardogs]

23. Yes. The same drug.

I wonder what the dosing protocol is

[uponit7771]

31. Hmmm sounds common

[MrsCoffee]

35. I was wondering the same as I also take plaquenil for lupus.

I will ask my doctor next month.

[Mendocino]

20. Quinine was used for malaria.

Quinine is the tonic, as in gin and tonic. The amount used in tonic for drinks is far too weak to be effective. Tonic syrup can be bought at places like Walmart and Target. The bark of the cinchona plant is the source.

Quinine has its own risks.


Ginger reportedly has anti-viral properties.

[milestogo]

22. Malaria drug. Rather unpleasant, as I recall.

[mahina]

30. Seconded

[Recursion]

34. Dreams like a Hieronymus Bosch painting (nt)

[a la izquierda]

40. Indeed.

I had a panic attack from my dreams one night.

[Laura PourMeADrink]

26. What about copper?

[defacto7]

27. This is a reliable source. Sounds promising.

[MontanaMama]

28. Dang. I'm not a tonic fan.

But I’ll become one if that’s what it takes. Bottoms up!

[mahina]

29. Fabulous!

If I recall correctly, diarrhea, headaches, blurred vision, nausea, and really grumpy mood.

But breathing!

[uponit7771]

37. Has anyone found out if gin and tonic truly works for coronavirus?

[jmowreader]

38. Not the kind we have in the US

Quinine has side effects and we don’t have much malaria here, so they put in just enough quinine to flavor the drink.

And don’t get the idea that you can make up for it by drinking more tonic water...you’d be into Water Intoxication territory (which can be fatal) before you drank enough tonic water to do anything for your malaria or coronavirus.

On the other hand, it’d have to work as well as anything Trump might suggest.

[Native]

43. On Rachel tonight, top epidemiologist in the U.S. recommended this. Said the U.S. isn't interested

in it because it's so old it's not patentable. Surprised?