Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19

[Newest Reality]

Chloroquine is the synthetic form of quinine that is derived from tree bark. In S. Korea they are combining chloroquine diphospate and zinc for ten-day treatments. Quinine and its variants do have side effects, of course, but this treatment is proving effective so far for the lethal pneumonia associated with the illness.

Note the source. This not a panacea from woo land. It is some good news, however.

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future.

https://www.ncbi.nlm.nih.gov/pubmed/32074550

[cyclonefence]

1. Gin and tonics!

for medicinal purposes only, of course.

[Siwsan]

3. You beat me to it!

I've got all of the ingredients required for this treatment trial.

[jberryhill]

4. No you don't

[Siwsan]

10. I prescribe a chill pill, for you.

[cyclonefence]

5. Definitely ready for human trials

[Ghost Dog]

15. Gin contains no quinine.

Schweppes tonic water does, unless they've changed the recipe since I last looked, many moons ago.

[jberryhill]

17. The FDA banned the form of quinine indicated in the article

It is not in any commercial tonic water available for retail sale in the US.

This is being pushed by anti-vaxxers:

Link to tweet

https://www.consumerreports.org/cro/2012/04/quinine-for-night-time-leg-cramps-no-longer-recommended/index.htm

Stop taking Quinine for night-time leg cramps

[cyclonefence]

33. Alcohol is a fine disinfectant

G&Ts originated as an effort to get folks who needed to take quinine take their quinine.

You know, like Julie Andrews MD said, "A spoonful of gin makes the quinine go down."

[Ghost Dog]

38. Ah. OK, cool...

...!

[jberryhill]

2. PLEASE NOTE THAT THIS OP IS EXTREMELY DECEPTIVE

The OP says "Note the source."

This is intended to make you believe that the NIH has anything to do with this completely unvetted information that has been circulating.

The "source" is simply an NIH publication database. Non-refereed publications can say "Mickey Mouse Cures Covid" and it will go into the PubMed database and get a URL.

OP, you asked "Note the source" - Do you even know what the source is of this publication with no methodology?

Here's a correction thread posted earlier on DU

https://www.democraticunderground.com/100213042640

Unfortunately, this particular piece of bullshit is going to be recycled endlessly on DU. Please keep an eye out for it.

[cyclonefence]

8. well dammit to hell

That is all.

On the other hand, could it hurt to try?

[jberryhill]

9. Yes, it can hurt to try

In fact, there is a Tweet going around which recommends a lethal dose.

https://www.thefix.com/quinine-potentially-lethal-ingredient-your-gin-and-tonic

Currently, there appears to be no way to determine if an individual is susceptible to quinine allergy—save from experiencing the reaction—and there is no clear-cut treatment. In the case of the patient cited in Dr. George's study, blood plasma exchange returned her to only partial health; she still suffers from migraines and reduced kidney function, as well as some mild cognitive impairment.

[cyclonefence]

34. Gosh, I stepped right in it, didn't I

Sorry to make light of such a serious subject.

[jberryhill]

35. I'm wound a little tight today

[cyclonefence]

36. Well, who isn't?

[Newest Reality]

18. You are jumping the gun, to say the least...

I don't know why you would use terms like deceptive and bullshit. I don't really appreciate that response to my post. This is under assessment and requires more clinical trials, which is the real point for posting it. It is not a cure or preventative, but more of a treatment of the secondary effect of pneumonia.

Your points are well taken, but the use of this treatment dates back to studies, like one in 2005 concerning SARS.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/

You will find a host of studies that cover the range of previous testing. This is not a new or decided issue, yet and I suggest you read all of the studies before calling bullshit, there are pros and cons so far with reported results. There are going to be many promising treatments being tested from a database of potentials. I don't see the review using such a term here and it does fit well with the subject:

In conclusion, the option of using chloroquine in the treatment of SARS-CoV-2 should be examined with attention in light of the recent promising announcements, but also of the potential detrimental effect of the drug observed in previous attempts to treat acute viral diseases. We urge Chinese scientists to report the interim trial results currently running in China as soon as they are available. This should be preferentially done in a peer-reviewed publication with detailed information to allow the international scientific community to analyse the results, to confirm in prospective trials the efficacy of the proposed treatment and to guide future clinical practice.

https://www.sciencedirect.com/science/article/pii/S0166354220301145

Let me know what you gather from the studies in total.

[jberryhill]

19. Bullshit

Your OP says:

"Note the source."

What did you mean to imply by that? That this somehow comes from the NIH? Just answer that question. What is the "source" you want readers to note.

[Newest Reality]

23. What it was...

That was a short abstract and pretty much sums up what is being done in China and now, South Korea.

I have supplied some more technical sources that include studies, and I have read several of them prior to posting. Have you read them yet? I would like to hear your response to the findings overall and how they relate to the information being provided. If you have a problem with those sources, that's not my problem.

There are many viable sources. Of course, you are aware as to why S. Korea is using zinc in combination with chloroquine, right? I mean, the basis for that has to do with the delivery of zinc ions, (see zinc ions and cell metabolism). They are basing their treatments on studies, not magic. We still have to get more conclusive results from them. I am stressing that they are not basing their tests and what they are choosing for treatment on what you are calling bullshit. Is that clear? There are sound reasons for them as per the studies provided.

What is your point though? Are you claiming that the health professionals and the research in China and South Korea is only woo and bullshit, (Chinese government conspiracy)? Or, are these professionals basing their tests and treatments on "bullshit"? I think that is more important. They have a database of over 5000 potential drugs to use right now, as well. Thankfully there is a good effort to collect and correlate studies based on their implications and significance since there isn't much time to respond to a new strain.

So, what is it?

[jberryhill]

25. Answer the question

You said "Note the source"

What was that intended to suggest?

Identify the "source" you wanted people to note.

[Claritie Pixie]

21. Please STOP this. In vitro testing with hydroxychloroquine shows good results.

Clinical trials are next. You can suspect the source of the information all you want but that doesn't mean the Chinese aren't on to something here.

Who made you an expert anyway?

[jberryhill]

24. The OP touts a "BREAKTHROUGH" based on a flawed publication....

Last edited Thu Mar 12, 2020, 03:51 PM - Edit history (1)

...and tries to fob it off as something that came from the NIH.

The OP is obviously deceptive.

Soap kills covid-19 in vitro too.

So, is anyone eating soap?

[Bradshaw3]

29. Thanks for the solid info

On both the source and the supposed "cure".

[intrepidity]

40. The source is not the NIH database

It's a peer-reviewed paper in a scientific journal called Bioscience Trends.

Did you know this, and if so, why do you call them an invalid source? Who is spreading the misinfo here?

https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_2020.01047/_article

I don't have a dog in this fight, other than having posted about this myself earlier. I have no opinion on the research itself, it's quality or otherwise.

What I don't understand is why you objected so loudly to it.

[WhiskeyGrinder]

6. Please delete this. Christ.

[jberryhill]

7. I think this is about the third go-round for this one

[Claritie Pixie]

22. Watch this.

[intrepidity]

39. Why should it be deleted?

It's a valid research article from a valid research journal, no? If you have evidence to the contrary, please present it.

Have you read the paper?

https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_2020.01047/_article

Hit the link called "Download PDF" and read it, if not.

[PunksMom]

11. I'm still going to

drink Gin👍🏼

[defacto7]

12. That's a reputable source.

Here's hoping.

[jberryhill]

14. No, it is not a reputable source

It is a completely unverified publication that was made back in February with no discernible methodology.

The link is merely to the PubMed database, which is simply an index of articles. The "source" is NOT the NIH.

This is bullshit which has been circulating for weeks.

[intrepidity]

27. Does Nature make your list of reputable sources?

Because according to this:

https://www.nature.com/articles/d41587-020-00003-1

At least ten clinical trials are testing chloroquine, approved as an antimalarial and autoimmune disease drug. In vitro, the endosomal acidification fusion inhibitor blocked infection of a clinical isolate of SARS-CoV-2.

Of course, Nature is just publishing the fact that there are ongoing clinical trials, not that they are working. But the point of a trial is... well, need I go on?

I think you owe the OP an apology.

[jberryhill]

28. Yes, and CDC looked into Morgellon's Disease too

You will note the complete absence in that article of any reference to any successful treatment of a single covid-19 patient.

Please feel free to explain how that article supports a "BREAKTHROUGH" as noted in the OP subject line.

The article you reference does not support the claim made in the OP, so asking if it is a reputable "source" is simply changing the subject.

[intrepidity]

30. I can't even formulate a proper response to this

Look, I respect your knowledge of law and many other topics, and dearly appreciate your sense of humor, so this isn't personal.

[jberryhill]

31. Oh, it's not personal either way

Here's the thing...

The OP touts a treatment "breakthrough" that is being widely lauded by anti-vax types and says "note the source". The "source" of that article is simply a self-published flimsy document with no supporting methodology, claiming successful treatment.

To then say, "but this article over here claims 'in vitro' success and says there is testing going on" doesn't do anything to support the touted "breakthrough" article.

There are many things that will kill covid-19 in vitro. There are obviously many things which are going to be tested.

There are people selling it online and pop-up Twitter accounts doing this:

-------------------
Replying to
@jasonvanschoor

@doctimcook
and 4 others

Coronavirus is a mild illness if you simply do this.

1. Request Remdesivir from Gilead.
2. Take 500mg Chloroquine salt 2X day for 4 days then 500mg day for 6 days.
3. Take 100mg Zinc 2X day. Chloroquine takes it into virus cell & kills it. #Covid19

Do that for all patients!
--------------------

People are going to get hurt.

[intrepidity]

32. Bioscience Trends isn't a reputable source?

If it had been the National Inquirer...

[Claritie Pixie]

13. I posted this a couple of days ago. Wonderful if it holds up!

[MyNameGoesHere]

16. Let's see.

Go to Binny's and buy a shit load of Gin
Order a truck load of Schweppes Tonic water and proceed to replace my blood with Gin and Tonics to scare the shit out of the Coronavirus? OK I handle that. What proof does my blood need to be at to work? 30%?

[Victor_c3]

20. Quinine is a fun medication to take

Two of the side affects I had when taking it in the past was lucid dreaming and hallucinations.

[Hoyt]

26. I suspect effective treatments (not cures) will be developed quickly. I heard one of the docs

yesterday say that most patients that need professional treatment basically get oxygen to help them breathe until they get better, rest and hydration. Some patients, unfortunately still get worse.

[DeminPennswoods]

37. What has happened to the vaccine that was developed during

SARS outbreak of the early 2000's, but never brought to market? Everything I have read from reputable sources says that SARS-CoV-2 infects humans using the same "doorway" as original SARS. Yet I haven't heard anything about this older vaccine being manufactured and tried or being used as the basis for a newer drug.