SARS-CoV-2 productively infects human gut enterocytes

[LiberalArkie]

Abstract
The virus severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission via the respiratory route. However, clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) is highly expressed on differentiated enterocytes. In human small intestinal organoids (hSIOs), enterocytes were readily infected by SARS-CoV and SARS-CoV-2 as demonstrated by confocal- and electron-microscopy. Consequently, significant titers of infectious viral particles were detected. mRNA expression analysis revealed strong induction of a generic viral response program. Hence, intestinal epithelium supports SARS-CoV-2 replication, and hSIOs serve as an experimental model for coronavirus infection and biology

Snip (All the science stuff)

SARS-CoV-2 is the third highly pathogenic coronavirus (after SARS-CoV and MERS-CoV) to jump to humans within less than 20 years suggesting that novel zoonotic coronavirus spillovers are likely to occur in the future. Despite this, limited information is available on coronavirus pathogenesis and transmission. This is in part due to the lack of in vitro cell models that accurately model host tissues. Very recently, it was shown that human iPS cells differentiated toward a kidney fate support replication of SARS-CoV-2 (13). Our data imply that human organoids represent faithful experimental models to study the biology of coronaviruses.

Snip (the reference notes)

https://science.sciencemag.org/content/early/2020/04/30/science.abc1669

[hlthe2b]

1. I read a lot of medical journal articles & always enjoy noting the wording from Scandinavian & Euro

journals. "Organoids" gives it away immediately. (In this case, the authors are from the Netherlands).

[Solomon]

2. So wtf are you saying?

[LiberalArkie]

3. I have no idea.. But as a lay person it may explain why some people have the gut problem

instead of lung. And the part where all the diseases have occurred in the last 20 years. It take someone with more than my 1 brain cell left to explain the article.

[roamer65]

4. For some people CV resembles a norovirus infection.

It causes gastroenteritis like symptoms.

Strange little virus. Mother Nature throws us yet another curve ball.

[kentuck]

5. Doctors keep discovering new ways the coronavirus attacks the body

https://www.msn.com/en-us/health/health-news/doctors-keep-discovering-new-ways-the-coronavirus-attacks-the-body/ar-BB13SoPn?ocid=DE_20200511_ENUS_daily_1

[LiberalArkie]

6. Very good.. Thank you

[ecstatic]

7. Does this mean that people can catch the virus from food?

I wish the researchers would hurry up and study this important question.

Sprinkle some Corona on food and give it to some unfortunate lab rats.

[woodsprite]

8. Thanks for posting. Here's another article talking about the gut issues.

My friend, a research assistant, posted this to her FB page a few days ago. She is currently caught in this intermittent rotation of gut/brain fog/shortness of breath parts of the C19 recovery process. It's a short overview of the Science article. Essentially,

"The observations made in this study provide definite proof that SARS-CoV-2 can multiply in cells of the gastrointestinal tract. However, we don't yet know whether SARS-CoV-2, present in the intestines of COVID-19 patients, plays a significant role in transmission. Our findings indicate that we should look into this possibility more closely," said Bart Haagmans of Erasmus MC University Medical Center."

https://www.labroots.com/trending/cell-and-molecular-biology/17554/sars-cov-2-infect-intestinal-cells?fbclid=IwAR0e9K0wz3xSrIbwNdKBvjiqVEq7hbitQWjRSYoTXomhW1j2hth2kks6-e8

This bodes well for those beaches that have reopened their public bath houses. My MIL said the beaches near her in FL have reopened theirs (Englewood, Blind Pass, Gasparilla areas).