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Fri Oct 1, 2021, 01:53 PM

Science wins. COVID-19 deaths/hospitalizations could soon be rare... no vaccine required.

https://www.reuters.com/business/healthcare-pharmaceuticals/mercks-covid-19-pill-cuts-risk-death-hospitalization-by-50-study-2021-10-01/

Oct 1 (Reuters) - An antiviral pill developed by U.S. drugmaker Merck & Co (MRK.N) could half the chances of dying or being hospitalized for those most at risk of contracting severe COVID-19, with experts hailing it as a potential breakthrough in how the virus is treated.

If it gets authorization, molnupiravir, which is designed to introduce errors into the genetic code of the virus, would be the first oral antiviral medication for COVID-19.

Merck and partner Ridgeback Biotherapeutics said they plan to seek U.S. emergency use authorization for the pill as soon as possible and to make regulatory applications worldwide.

"An oral antiviral that can impact hospitalization risk to such a degree would be game changing," said Amesh Adalja, senior scholar at the Johns Hopkins Center for Health Security.


Note: read the article. The clinical studies are so successful they've been requested to stop the trials and go straight to approval under emergency use.

Basically... it's Tamiflu for C19.

74 replies, 5966 views

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Reply Science wins. COVID-19 deaths/hospitalizations could soon be rare... no vaccine required. (Original post)
WarGamer Oct 2021 OP
CaliforniaPeggy Oct 2021 #1
WarGamer Oct 2021 #2
PortTack Oct 2021 #3
SergeStorms Oct 2021 #54
mindfulNJ Oct 2021 #4
iemanja Oct 2021 #6
lagomorph777 Oct 2021 #23
Grokenstein Oct 2021 #34
Maru Kitteh Oct 2021 #66
Rebl2 Oct 2021 #41
onetexan Oct 2021 #47
paleotn Oct 2021 #48
calimary Oct 2021 #56
Ftrump Oct 2021 #60
NightWatcher Oct 2021 #5
ejbr Oct 2021 #24
hibbing Oct 2021 #43
Irish_Dem Oct 2021 #7
tinrobot Oct 2021 #27
Irish_Dem Oct 2021 #35
paleotn Oct 2021 #51
wnylib Oct 2021 #53
Jirel Oct 2021 #8
WarGamer Oct 2021 #12
NickB79 Oct 2021 #21
eppur_se_muova Oct 2021 #38
Hav Oct 2021 #31
Miguelito Loveless Oct 2021 #9
WarGamer Oct 2021 #15
Nevilledog Oct 2021 #20
Grokenstein Oct 2021 #39
Runningdawg Oct 2021 #10
WarGamer Oct 2021 #11
luvtheGWN Oct 2021 #59
Runningdawg Oct 2021 #63
luvtheGWN Oct 2021 #67
bluewater Oct 2021 #13
Hav Oct 2021 #28
WarGamer Oct 2021 #32
crimycarny Oct 2021 #55
LanternWaste Oct 2021 #14
WarGamer Oct 2021 #16
lagomorph777 Oct 2021 #25
ProfessorGAC Oct 2021 #62
lagomorph777 Oct 2021 #73
Earth-shine Oct 2021 #17
progressoid Oct 2021 #36
PSPS Oct 2021 #18
WarGamer Oct 2021 #19
zaj Oct 2021 #22
lagomorph777 Oct 2021 #26
Danascot Oct 2021 #40
IronLionZion Oct 2021 #29
Jakes Progress Oct 2021 #30
relayerbob Oct 2021 #33
Hav Oct 2021 #37
EleanorR Oct 2021 #50
beaglelover Oct 2021 #42
Mr. Ected Oct 2021 #44
Stargleamer Oct 2021 #45
dawg Oct 2021 #52
BlueIdaho Oct 2021 #46
Crunchy Frog Oct 2021 #69
BlueIdaho Oct 2021 #72
dawg Oct 2021 #49
StarryNite Oct 2021 #61
CCExile Oct 2021 #57
Aussie105 Oct 2021 #58
Crunchy Frog Oct 2021 #70
Azathoth Oct 2021 #64
DET Oct 2021 #65
Crunchy Frog Oct 2021 #71
Steelrolled Oct 2021 #68
lagomorph777 Oct 2021 #74

Response to WarGamer (Original post)

Fri Oct 1, 2021, 01:56 PM

1. It certainly sounds great right now.

Let's hope that this promise is one that can be kept.

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Response to CaliforniaPeggy (Reply #1)

Fri Oct 1, 2021, 01:56 PM

2. over 5 million Global dead... this would be HUGE.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 01:57 PM

3. Science always wins!! Really good news

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Response to PortTack (Reply #3)

Fri Oct 1, 2021, 04:14 PM

54. But how much will...

BIG PHARMA charge for this "miracle" drug?

I imagine it will be around $5 Canadian, and $500,000 in the U.S. It's that exchange rate, you know?

You can't put a price on human life, but this will give the anti-vax people another reason not to get vaccinated.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 01:58 PM

4. I predict

that the nut-job anti vaxxer conspiracy theorists will refuse this too.

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Response to mindfulNJ (Reply #4)

Fri Oct 1, 2021, 02:00 PM

6. Yep

They'll stick with their horse dewormer.

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Response to mindfulNJ (Reply #4)

Fri Oct 1, 2021, 02:45 PM

23. Fine.

They can drink their Clorox or alien blood or whatever.

We'll be watching the demographic needle move.

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Response to mindfulNJ (Reply #4)

Fri Oct 1, 2021, 02:57 PM

34. "ECKS PERRY MENTAL"??2??

"No way, I'm not taking that! SHAKE UP WEEPLE! It's an Illuminati plot to depopulate the nation and leave us vulnerable to takeover!! BOOGA BOOGA BOO!!"

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Response to Grokenstein (Reply #34)

Fri Oct 1, 2021, 09:04 PM

66. Omygrd they're all from Montana lately.




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Response to mindfulNJ (Reply #4)

Fri Oct 1, 2021, 03:21 PM

41. Of course

they will

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Response to mindfulNJ (Reply #4)

Fri Oct 1, 2021, 03:46 PM

47. Let them suffer the consequences of their stupidity

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Response to mindfulNJ (Reply #4)

Fri Oct 1, 2021, 03:51 PM

48. Hey, whatever.

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Response to mindfulNJ (Reply #4)

Fri Oct 1, 2021, 04:15 PM

56. Fine with me.

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Response to mindfulNJ (Reply #4)

Fri Oct 1, 2021, 04:51 PM

60. They won't even have to work too hard on this one, they'll spin the drug's mechanism of action

so the dis-informed will believe molnupiravir was designed to introduce errors in the genetic code of people

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 01:58 PM

5. I'm going to do my own research, thanks.

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Response to NightWatcher (Reply #5)

Fri Oct 1, 2021, 02:47 PM

24. Lol n/t

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Response to NightWatcher (Reply #5)

Fri Oct 1, 2021, 03:24 PM

43. hehe

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 02:01 PM

7. Will the anti-vaxxers accept this pill?

Or will they treat it like masks and the vaccine?

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Response to Irish_Dem (Reply #7)

Fri Oct 1, 2021, 02:49 PM

27. Only if they can wash it down with bleach.

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Response to tinrobot (Reply #27)

Fri Oct 1, 2021, 02:57 PM

35. They are hell bent on killing themselves, aren't they?

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Response to Irish_Dem (Reply #7)

Fri Oct 1, 2021, 03:52 PM

51. Honestly, I really don't care.

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Response to Irish_Dem (Reply #7)

Fri Oct 1, 2021, 03:55 PM

53. It sounds like a scientific breakthrough

Last edited Fri Oct 1, 2021, 10:21 PM - Edit history (1)

in treating viruses. I am a strong supporter of vaccines, masks, and other precautions. I am not anti science. But I do have some reservations about this pill. If I were sick with covid I would probably take it if offered. But since this pill works by introducing viral mutations to gum up the process of the coronavirus self-replications, I wonder what the long term effects could be of the mutations. They are supposed to act like reproduction inhibitors, but can the mutated virus particles develop their own strength by merging?

Cancer is closely related to viruses. We know now, for example, that cervical cancer is caused by a virus.

This pill looks promising and I'd love to see it work safely. The concept of its mechanism might be useful in other diseases, too. I just feel a bit cautious.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 02:03 PM

8. WHOA there!

Yes, it's Tamiflu for COVID. But a 50% reduction is hardly making COVID hospitalizations and deaths preventable with a pill. They are improving their chances far more with a vaccine. But, yes, the new medications (several companies are in testing) are a big win.

Just wait. The next big conspiracy theory is that lizard people are candy-coating their eggs to hatch in the unsuspecting stomachs of anyone who takes this Merck medication...

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Response to Jirel (Reply #8)

Fri Oct 1, 2021, 02:12 PM

12. Still really early but 0 deaths in trials while the placebo group had 8 deaths

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Response to Jirel (Reply #8)

Fri Oct 1, 2021, 02:44 PM

21. Exactly. We're seeing 2,000 dead each day

Halve that and you're still losing 1,000 a day.

Vaccines are still vitally important.

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Response to NickB79 (Reply #21)

Fri Oct 1, 2021, 03:04 PM

38. Grammar Nazi salute ! nt

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Response to Jirel (Reply #8)

Fri Oct 1, 2021, 02:54 PM

31. Agreed,

anything that helps reduce hospitalization is welcome but a 50% reduction won't make it rare.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 02:05 PM

9. I am sure that this will not be anywhere as effective

as the next "cure" from the fever swamp, Grape Pez™ soaked in Sterno™.

Accept no substitute. If you can't light your Pez™ on fire and smell grape smoke, it's a libtard counterfeit.

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Response to Miguelito Loveless (Reply #9)

Fri Oct 1, 2021, 02:14 PM

15. Rumor has it that the Merck pill is just a mix of ivermectin, HCQ and bleach

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Response to WarGamer (Reply #15)

Fri Oct 1, 2021, 02:23 PM

20. Even better......Merck also makes Ivermectin.

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Response to Nevilledog (Reply #20)

Fri Oct 1, 2021, 03:08 PM

39. Which is why it's so hilarious

that idiot cartoonist Ben Garrison claims eating horse paste "sticks it to Big Pharma." He thinks Dr. Fauci is "Big Pharma."

He also claimed he and his wife caught COVID despite their daily regimen of beet juice, zinc and prayer. A couple of days ago he declared himself fully recovered (link trigger warning: sampling of utterly bonkers Garrison toons) with "total natural immunity" thanks to God's "healing protection." You can actually smell the bullshit through the Internet!

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 02:05 PM

10. Nothing I have yet read claims it is a preventative.

It's a treatment that won't require leaving your home to take.

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Response to Runningdawg (Reply #10)

Fri Oct 1, 2021, 02:10 PM

11. in the trials, zero deaths.

But 8 deaths in the placebo group.

This isn't "official" yes it's still early... but looks damn good.

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Response to Runningdawg (Reply #10)

Fri Oct 1, 2021, 04:51 PM

59. Yes, a preventative.

According to a scientist on CNN, timing is imperative. Must be taken as soon as possible after initial infection.

It does NOT take the place of the vaccine.

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Response to luvtheGWN (Reply #59)

Fri Oct 1, 2021, 07:56 PM

63. If it were a preventative you would take it BEFORE infection. It's not.

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Response to Runningdawg (Reply #63)

Fri Oct 1, 2021, 09:47 PM

67. You are almost correct, but

it's a preventative in that it prevents you from becoming seriously ill and hospitalized. and that is the point of it.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 02:13 PM

13. Costs vs Vaccine Costs?

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Response to bluewater (Reply #13)

Fri Oct 1, 2021, 02:52 PM

28. According to the article it's 700 for the pill treatment

Maybe this price contains help to get the new drug on the way. The numbers for the vaccine I saw were around 20$.

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Response to Hav (Reply #28)

Fri Oct 1, 2021, 02:54 PM

32. But the pill is only given to people who need it...

Ones with a positive test and at least one pre-existing condition.

It is a fraction of the price of the vaccination effort.

And combine BOTH a vaccinated public AND an effective therapeutic and we're gonna' beat this thing.

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Response to WarGamer (Reply #32)

Fri Oct 1, 2021, 04:15 PM

55. Yep--and immunocompromised now have a weapon

Since those who are immunocompromised often can't build up a strong enough immune response from the vaccine, having an effective antiviral is key to their surviving COVID.

I hoping this antiviral can also be used prophylactically. I've been keeping my eye on another antiviral in the pipeline which is a joint effort between ATEA Pharma and Roche (Roche is the maker of Tamiflu).

This is good news...

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 02:13 PM

14. Anthropomorphizing science

 

Science neither wins nor loses any more than an area of vacuum in space feels lonely.

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Response to LanternWaste (Reply #14)

Fri Oct 1, 2021, 02:15 PM

16. lol... good one, LW...

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Response to LanternWaste (Reply #14)

Fri Oct 1, 2021, 02:47 PM

25. Why do you think space invented Dark Energy?

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Response to lagomorph777 (Reply #25)

Fri Oct 1, 2021, 05:03 PM

62. Not What I Heard

I heard dark energy invented space, but then space got snooty & ignores dark energy!

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Response to ProfessorGAC (Reply #62)

Mon Oct 4, 2021, 08:13 AM

73. These are dark matters.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 02:15 PM

17. I'll bet these pills are the perfect size to hide the Bill Gates microchips.

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Response to Earth-shine (Reply #17)

Fri Oct 1, 2021, 02:59 PM

36. Exactly!!11!

If you sheep wanna stick that stuff in your body go ahead. I'm going with more safe things like ivermectin and bleach!

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 02:16 PM

18. Don't pop the cork just yet

On the NPR piece about this, they said that Merck says there is a chance of "genetic mutations" with molnupiravir. So, while it may be useful as a palliative, it falls far short when comparing it to the vaccines.

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Response to PSPS (Reply #18)

Fri Oct 1, 2021, 02:18 PM

19. Hopefully we'll see soon...

from Reuters: (note the sloppy typo I corrected re: pregnancy)

Merck has said data shows molnupiravir is *not capable* of inducing genetic changes in human cells, but men enrolled in its trials had to abstain from heterosexual intercourse or agree to use contraception. Women of child-bearing age in the study could (not?) be pregnant and also had to use birth control.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 02:45 PM

22. Watch MAGA race to "introduce errors into the genetic code"

 

That is some comically devious language that they are going to love ignoring as they celebrate this anti-vaxx cure!

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Response to zaj (Reply #22)

Fri Oct 1, 2021, 02:49 PM

26. I heard they are embedding the DaVinci Code into the genetic code.

The vaccine is turning people into Rosicrucians.

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Response to zaj (Reply #22)

Fri Oct 1, 2021, 03:18 PM

40. A few errors in their genetic code

might be an improvement.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 02:52 PM

29. Nice try Merck. We know they make Ivermectin which is much cheaper



Deplorables probably won't trust it because "designed to introduce errors into the genetic code" to turn humans into zombies or something.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 02:53 PM

30. World changing if so. No refrigeration or technicians.

Send millions of pills to India and Africa.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 02:54 PM

33. Ah, that's much, more space for the microchips

The vaccine ones were tiny, didn't last long with the little batteries. Hard to get good reception with antennas so small.

This will be like upgrading to a supercomputer. Gates and Soros will be soooo happy

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 03:04 PM

37. "no vaccine required"

It seems to be a very welcome treatment once you get infected but it shouldn't be seen as a replacement for the vaccine.

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Response to Hav (Reply #37)

Fri Oct 1, 2021, 03:51 PM

50. Thank you. We should not in any way be discouraging people from getting vaxed NT

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 03:21 PM

42. This is such awesome news! There is a huge light at the end of the tunnel and I can see

our maskless future from here!!!!!!! Yippee!!!!

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 03:34 PM

44. Sadly, this was in the news several months ago. They even targeted end of 2021 for release.

The news we receive regarding the advancement of science in the pursuit of taming COVID seems to be incomplete at times.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 03:37 PM

45. Why can't they have a vaccine that "introduces errors into the AIDS virus"?

It seems possible; AIDS virus has remained a hard nut to crack

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Response to Stargleamer (Reply #45)

Fri Oct 1, 2021, 03:52 PM

52. It's a more difficult virus than Covid.

They are trying.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 03:46 PM

46. Better check the price first.

If it’s anything like the Harvoni I took to beat Hepatitis C virus - it could be $1,000 a pill. I’m grateful I was finally able to beat that disease but it was a $90,000+ treatment which my insurance company did not cover.

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Response to BlueIdaho (Reply #46)

Fri Oct 1, 2021, 10:07 PM

69. You can get it for a few hundred $ from India.

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Response to Crunchy Frog (Reply #69)

Sat Oct 2, 2021, 10:11 AM

72. Now you can...

It’s an older treatment that’s not the drug du jour. I was taking at when it was the only cure available. Then you could fly to India, get diagnosed, pay for the Rx and save half. No one was shipping from India to the states back then.

I’m grateful costs are going down for anti-viral drugs - just don’t expect the first Covid anti-viral to be cheap. This is a capitalist healthcare system.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 03:51 PM

49. The expectation is for a 50% reduction in deaths from this treatment.

Last edited Fri Oct 1, 2021, 05:21 PM - Edit history (1)

That's excellent, but vaccines are still needed and they will remain the most critical part of the overall response to the pandemic.

For every 100 lives the Merck treatment saves, there may be another 100 who will still die.

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Response to dawg (Reply #49)

Fri Oct 1, 2021, 04:59 PM

61. Exactly

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 04:22 PM

57. The picture I saw of these pills showed them as small and brown.

Conservatives will think they are mooslim or messican, so they possibly won't take them. However, they DO have Merck on them, just like Amercka8, so maybe they will. They'd still have more faith in them if they were white.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 04:27 PM

58. Hospital only drug, I'd say.

Another tool for hospitals to use in helping Covid victims to survive.

Don't expect to see it on the shelves of Supermarkets or drug stores for home treatment.

Needs approval first, then mass production and distribution.

Definitely NOT a replacement for vaccinations.

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Response to Aussie105 (Reply #58)

Fri Oct 1, 2021, 10:14 PM

70. No. It's for use ASAP after + test.

Has to be taken within the first few days of infection. By the time someone is in the hospital it's probably too late for it to do any good.

Still not a substitute for vaccination, but should at least keep a lot of antivaxxers from clogging up the hospitals.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 08:26 PM

64. Honestly, that drug sounds like what the anti-vaxxers accuse the vaccines of being

It's designed not to inhibit viral replication but to introduce random viral RNA replication errors. While most of the time that leads to increasingly impaired/sterile virus copies, it also strikes me as increasing the liklihood of an accidental fitness-enhancing mutation.

Not to mention the drug belongs to a class of drugs that are known to be mutagenic.

Honestly, I'd be more comfortable with the vaccine.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 08:55 PM

65. Not So Fast

The anti-vaxxers won’t take this pill once they hear the words “genetic mutations”. I can hear the conspiracy theories now. Plus, they’ll insist on receiving the most costly antiviral, which is probably Remdisavir. Of course, they have no intention of paying for any of this.

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Response to DET (Reply #65)

Fri Oct 1, 2021, 10:21 PM

71. They think Remdesivir is killing them.

They want their hydroxychloroquine and horse paste.

They'll probably take this though, as panic tends to set in once they test positive.

It should provide plenty of interesting sociological observations though.

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Response to WarGamer (Original post)

Fri Oct 1, 2021, 09:54 PM

68. I'll admit the phrase "introduce errors into the genetic code of the virus"

 

sounds more frightening than anything I have read about the vaccines. On the other hand, you only take this if you have already gotten COVID-19, so you are more likely to say "damn the generic errors, let me have it!"

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Response to WarGamer (Original post)

Mon Oct 4, 2021, 08:35 AM

74. Ummm, no, Reuters/Tass. The pill doesn't stop the spread, you idiots.

The vaccine reduces spread by reducing the likelihood that you'll become significantly infected. The pill is only given after you're showing symptoms and spreading the plague.

Clever new spin on Putin/Trump's antivaxx theme.

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