General Discussion
Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsMore than 1 in 10 Americans takes SSRIs -
Have more than 1 in 10 Americans engaged in violent assaults?
http://psychcentral.com/news/2009/08/03/antidepressant-use-up-75-percent/7514.html
Can we please have an end to the "SSRIs made him do it threads"?
http://www.webmd.com/depression/ssris-myths-and-facts-about-antidepressants
GreenPartyVoter
(72,377 posts)hedgehog
(36,286 posts)mess up your sex life is that life is so much worse if you don't take the drug!
GreenPartyVoter
(72,377 posts)Th1onein
(8,514 posts)GlaxoSmithKline's data from all of their placebo-controlled paroxetine trials showed "hostility events" (which includes mere thoughts as well as actions) in a total of 60 out 9219 paroxetine cases (0.65%) and 20 out of 6455 placebo cases (0.31%). From here: http://www.plosmedicine.org/article/slideshow.action?uri=info:doi/10.1371/journal.pmed.0030372
That's only ONE of the SSRI drugs (Paxil); there are quite a few copycats out there. There are black box warnings on these drugs, for God's sake, about them causing suicidal and homicidal behavior. Are we supposed to just ignore them?
I am all for a gunless society. I am a pacifist. But we cannot ignore this link. It takes only one violent episode and one person on these drugs can take out dozens.
hedgehog
(36,286 posts)"Conclusions: In both the United States and the Netherlands, SSRI prescriptions for children and adolescents decreased after U.S. and European regulatory agencies issued warnings about a possible suicide risk with antidepressant use in pediatric patients, and these decreases were associated with increases in suicide rates in children and adolescents."
http://ajp.psychiatryonline.org/article.aspx?articleid=98898
http://www.aacap.org/cs/root/developmentor/do_antidepressants_increase_the_risk_of_suicide_in_children_and_adolescents
Th1onein
(8,514 posts)That's a fact. The following is from Harvard Medical School. http://www.health.harvard.edu/newsweek/What_are_the_real_risks_of_antidepressants.htm
Suicide. The risk that antidepressants will incite violent or self-destructive actions is the subject of renewed controversy. Suicidal thoughts (although no suicides) in patients taking SSRIs were first reported in 1990, shortly after the drugs were introduced. An FDA committee rejected the association, and most mental health professionals accepted that conclusion. But the issue was never completely settled.
One reason for concern is the increasing number of children and adolescents receiving prescriptions for antidepressants. An analysis of clinical trials in patients under age 18 found that SSRIs raised the risk of suicidal thinking when compared with a placebo. Many studies have followed, and although results vary, there is a consistent trend. When compared with a placebo, all antidepressants, including SSRIs, seem to double the risk of suicidal thinking, from 1%2% to 2%4%, in both children and adults.
In October 2004, after much hesitation and pressure from parents and Congress, the FDA issued a Black Box Warning for physicians and pharmacists its strongest available measure short of withdrawing a drug from the market. The warning is placed on package inserts for all antidepressants in common use. It mentions the risk of suicidal thoughts, hostility, and agitation in both children and adults, specifically citing statistical analyses of clinical trials. The FDA has also issued a public advisory to parents, physicians, and pharmacists, and it will develop an information guide to be distributed with each new prescription.
BigDemVoter
(4,149 posts)When somebody is terribly, terribly depressed, they don't even have the energy to commit suicide. Once they start on anti-depressants, they are sometimes at the highest risk at the beginning of their therapy, as they have more energy and are consequently MORE likely to commit suicide. Bizarre, but apparently true.
ceile
(8,692 posts)hedgehog
(36,286 posts)"The adolescent suicide rate declined nearly 15% in the United States between 1985 and 1999, while use of SSRIs in that age group was rising by nearly 70%. Only 20% of adolescents who commit suicide have ever taken an antidepressant drug."
cthulu2016
(10,960 posts)are not suicides.
SidDithers
(44,228 posts)Sid
FarCenter
(19,429 posts)http://www.scientificamerican.com/article.cfm?id=antidepressants-do-they-work-or-dont-they
http://www.ncbi.nlm.nih.gov/pubmed/20051569?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1
hedgehog
(36,286 posts)drugs or drug combinations before they find one that works. Clearly, the placebo effect doesn't emerge in real life! On the other hand, if say Drug A is effective for only 20% of the people using it, it will turn up as only 20% effective for a random group of people. It's like treating people with viral pneumonia with penicillin, then announcing that penicillin is no more effective than a placebo! The problem we have today is that we don't know how to diagnose depression well enough to differentiate between those that respond to Drug A and those that respond to drug B.
FarCenter
(19,429 posts)The patient gets better for other reasons while trying out the series of drugs.
Its like going to the doctor with a bad cold, getting an antibiotic, and getting better. The antibiotic has no effect on the cold virus, but the body's immune system fights off the cold while it is being taken.
octoberlib
(14,971 posts)And also the fact that depression caused by chemical imbalance has never been proven. Chemical imbalance is basically a term used by the drug companies(and some psychiatrists ) to market their drugs.
Oops, I meant to reply to FarCenter.
green for victory
(591 posts)is that only reserved for "alternatives"
@WooWoo
#WooWoo
Come 'n git it
Liberalynn
(7,549 posts)with the OP
LisaLynne
(14,554 posts)Comrade_McKenzie
(2,526 posts)I hope drug companies start suing people that claim this stuff...
We don't need stigmas attached to medication that helps people.
HiPointDem
(20,729 posts)aggregate?
what a great idea!
green for victory
(591 posts)http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1564177/
Both clinical trial and pharmacovigilance data point to possible links between these drugs and violent behaviours. The legal cases outlined returned a variety of verdicts that may in part have stemmed from different judicial processes. Many jurisdictions appear not to have considered the possibility that a prescription drug may induce violence.
..In these trials, hostile events are found to excess in both adults and children on paroxetine compared with placebo, and are found across indications, and both on therapy and during withdrawal. The rates were highest in children with obsessive-compulsive disorder (OCD), where the odds ratio of a hostile event was 17 times greater (95% confidence interval
Emotional blunting
Another mechanism that may contribute to hostile events is treatment-induced emotional blunting. Several reports published since 1990 have linked SSRI intake with the production of emotional blunting, detachment, or an amotivational syndrome, described in one report as the equivalent to a
chemical lobotomy
. It is quite common in clinical practice to find people who say they simply are not bothered any more. Things that would previously have worried them no longer do so...
Mania and psychosis
Another mechanism that may link SSRIs to violence are the manic or psychotic states reported to be induced by drug treatment. These drug-induced states often resolve once the medication is removed. However, the full dimensions of treatment-induced psychotic or manic reactions have yet to be mapped; some may continue for a long period after treatment has stopped . It has recently been estimated that these drug-induced manic or psychotic states may account for up to eight percent of admissions to psychiatric facilities .
...The development of a psychotic episode or of command hallucinations has traditionally been linked to both violence and suicide. The labels for most SSRIs now concede a causal relationship to psychosis and to hallucinations...(more)
Conclusion
The new issues highlighted by these cases need urgent examination jointly by jurists and psychiatrists in all countries where antidepressants are widely used. The problem is international, and it would make sense to organise an international effort now.
Annex: The Illustrative Medico-Legal Cases
Case 1
DS was a 60-year-old man with a history of five prior anxiety/depressive episodes. These did not involve suicidality, aggressive behaviour, or other serious disturbance. All prior episodes had resolved within several weeks...
...In 1998, a new family doctor, unaware of this adverse reaction to fluoxetine, prescribed paroxetine 20 mg to DS, for what was diagnosed as an anxiety disorder. Two days later having had, it is believed, two doses of medication, DS using a gun put three bullets each through the heads of his wife, his daughter who was visiting, and his nine-month-old granddaughter before killing himself.
Case 3
DH was a 74-year-old man from New South Wales with a history of mixed anxiety/depressive episodes, many of which resolved without drug treatment. He had no history of violence or suicidality, and had remained gainfully employed throughout...
That night, apparently feeling worse after a first dose of sertraline, DH took four more doses of sertraline. The next morning, after his wife got up he met her in the kitchen and strangled her...(more)
(More cases detailed at link)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1564177/
http://www.democraticunderground.com/10022008133#post6
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Failure to heed the Governments warnings could lead to more deaths.
dipsydoodle
(42,239 posts)there is at present nothing to suggest he was taking anything other than conjecture in some of the media.
ellisonz
(27,709 posts)Several European states conduct psychological reviews for gun ownership, I've never seen anything to suggest that taking anti-depressants were a disqualifier.