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FLPanhandle

(7,107 posts)
Thu May 14, 2015, 08:39 PM May 2015

Viagra may help cure malaria, research suggests

VIAGRA COULD STOP MALARIA
THE LITTLE PILL HARDENS BLOOD CELLS TO FIGHT OFF PARASITES

Since it first came on the market in 1998, Viagra has been found to address more conditions than just erectile dysfunction—it treats hypertension, altitude sickness, and prostate cancer. Now a team of European researchers has found that everyone’s favorite little blue pill can prevent malaria because of the way an enzyme affects red blood cells, according to a study published in PLOS Pathogens.

Malaria is caused by a parasite that lives in blood and is transmitted between people through mosquito bites. The sexual form of the parasite, Plasmodium falciparum, goes through some stages of its development in mosquitoes, but spends one very important stage in human red blood cells found in bone marrow. Once in the blood, these cells give the impression of being healthy because they are squishy, which allowed them to slip by the spleen, which normally looks for abnormal or dead blood cells, which are firmer, and filters them out.

The researchers figured that a good way to engage the spleen’s cleansing power would be to harden the red blood cells. Viagra, which works for its intended purpose by relaxing certain muscles to increase blood flow, allows the infected cells to remain stiff by inhibiting an enzyme that would keep them squishy. In this study, the researchers tested Viagra on the blood in an artificial spleen and found that the spleen easily weeded out the hardened red blood cells. The researchers see their work as the first step towards new types of antimalarials.

http://www.popsci.com/viagra-could-stop-malaria




This will arouse great interest in the medical community (yes, I went there)

7 replies = new reply since forum marked as read
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Viagra may help cure malaria, research suggests (Original Post) FLPanhandle May 2015 OP
the most fun way to cure malaria, bar none! nt steve2470 May 2015 #1
In all seriousness Kber May 2015 #2
Do they still give you Plaquenil (hydroxychlorochine)? NightWatcher May 2015 #4
Mostly chloroquine in the military Warpy May 2015 #5
I have to look and see Kber May 2015 #7
well, mosquitoes can't fly with erections ... kwassa May 2015 #3
So, red blood cells become stiff with Viagra? longship May 2015 #6

Kber

(5,043 posts)
2. In all seriousness
Thu May 14, 2015, 09:02 PM
May 2015

The currently available anti malaria meds are tough on the stomach.

I travel to malaria infected countries regularly for business and the meds are hard to take.

On the other hand at least I can get through a meeting with minimal distraction.

NightWatcher

(39,343 posts)
4. Do they still give you Plaquenil (hydroxychlorochine)?
Thu May 14, 2015, 09:09 PM
May 2015

I've been on it for 3 years for a non-malaria condition. (lupus)

Warpy

(111,107 posts)
5. Mostly chloroquine in the military
Thu May 14, 2015, 09:18 PM
May 2015

which has even more fun side effects than Plaquenil does.

Plaquenil is given to civilians traveling to countries where malaria transmission is frequent but in much lower doses than is given to people with RA or lupus.

Kber

(5,043 posts)
7. I have to look and see
Thu May 14, 2015, 09:37 PM
May 2015

But it's tough enough that most trips I trust in bug spray and gin and tonics.

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