Dengue vaccine proves 100% effective in human trials

[Recursion]

http://www.wired.co.uk/news/archive/2016-03/17/dengue-vaccine-human-trial-complete-protection

An experimental vaccine against the dengue virus has been found to protect 100 percent of recipients in a clinical trial carried out by the USA's National Institute of Allergy and Infectious Diseases (NIAID).

In the NIAID trial 21 people were vaccinated with TV003, while 20 received a placebo. Six months later they returned to be infected with a mild version of dengue-2. All 21 people who'd received the vaccine were protected against infection. All 20 members of the placebo group contracted dengue. A modified version of the vaccine is now being developed in an attempt to treat the related Zika virus.

TV003 is a live attenuated vaccine, meaning that, like measles, mumps, and flu vaccines, it's made by creating a greatly weakened version of the virus it's designed to combat. Specifically, this vaccine involves a combination of four recombinant dengue vaccine candidate viruses, designed to combat all four major dengue virus serotypes.

The volunteers who received the vaccine experienced no ill effects from it and developed only a mild rash, which they didn't notice and which vanished entirely in five to ten days. All subjects successfully developed antibodies against dengue.

Fuck yeah science

[oldandhappy]

1. good news Thank you

[Scootaloo]

2. I'm having a stupidday, 'cause I got all excited...

Then realized this was about gengue and not malaria. You know, those mosquito diseases kinda go together.

Still, good news!

[Recursion]

6. Malaria already has prophylaxis; dengue hasn't so far

But, yeah. More children die from malaria than AIDS every year. It's a horrible disease.

[haikugal]

3. Science rocks!!

[tblue37]

4. I bet you won't find an anti-vax movement in countries where dengue is common,

Last edited Fri Mar 18, 2016, 11:20 AM - Edit history (1)

unlike first-worlders who think infectious diseases are less dangerous than vaccines--specifically because the effectiveness of vaccines has protected them from witnessing the devastation caused by diseases we don't have vaccines for.

(I wonder whether anti-vaxers would refuse an Ebola vaccine. I bet they would stand in line for one, even though the risk of Ebola is statistically nonexistent in this country.)

[Recursion]

12. Heh. It's my standing invitation to anti-vaxxers

Come to Mumbai and explain to parents why they "choose" not to vaccinate their children.

[stone space]

5. I'd like to get this.

Supposedly, I'm immune to 2 out of 4 strains of denge at this point, but I wouldn't mind protection against the 2 remaining.

[AllyCat]

7. This is a huge advance for human health

Incredible.

[Recursion]

8. Four guys on my soccer team got dengue last year

It's awful

[JDPriestly]

9. Great news. Thanks.

[salimbag]

10. Dengue can be fatal

In children under the age of four years, the mortality rate is very high. My daughter died from dengue in 1973. She was almost two years old. She was sick one day and dead the next morning. A vaccine would save children around the world. Thanks science.

[Recursion]

11. I'm so sorry about your daughter

It's a big problem here in Mumbai, but there isn't sufficient testing to distinguish it from malaria.

[SaintLouisBlues]

13. Our friendly neighbor Mexico is all over this

Mexico to get world's first dengue fever vaccine - BBC.com
www.bbc.com/news/world-latin-america-35056139
BBC
Dec 9, 2015 - Mexico has approved the use of the world's first vaccine against dengue fever, the health ministry announced. ... French pharmaceutical company Sanofi said it developed the vaccine, Dengvaxia, over the past 20 years. ... Dengue fever affects more than 400 million people a year...

[trotsky]

14. ...

[HuckleB]

15. Recommended!