Coronavirus destroys lungs. But doctors are finding its damage in kidneys, hearts and elsewhere.

[inanna]

Source: Washington Post

April 15, 2020 at 7:00 a.m. EDT

The new coronavirus kills by inflaming and clogging the tiny air sacs in the lungs, choking off the body’s oxygen supply until it shuts down the organs essential for life.

But clinicians around the world are seeing evidence that suggests the virus also may be causing heart inflammation, acute kidney disease, neurological malfunction, blood clots, intestinal damage and liver problems. That development has complicated treatment for the most severe cases of covid-19, the illness caused by the virus, and makes the course of recovery less certain, they said.

The prevalence of these effects is too great to attribute them solely to the “cytokine storm,” a powerful immune-system response that attacks the body, causing severe damage, doctors and researchers said.

Almost half the people hospitalized because of covid-19 have blood or protein in their urine, indicating early damage to their kidneys, said Alan Kliger, a Yale University School of Medicine nephrologist who co-chairs a task force assisting dialysis patients who have covid-19.

Read more: https://www.washingtonpost.com/health/coronavirus-destroys-lungs-but-doctors-are-finding-its-damage-in-kidneys-hearts-and-elsewhere/2020/04/14/7ff71ee0-7db1-11ea-a3ee-13e1ae0a3571_story.html

[no_hypocrisy]

1. Could it be possible to succumb to CV-19 years after "recovering" via the secondary organ damage?

[localroger]

4. It could shorten your life expectancy

Kind of like subacute radiation exposure, you might fall to a disease you would have otherwise survived years later but it would be nearly impossible to say with certainty that your previous exposure caused your premature death. It would, however, show up in a statistical comparison of people who had the previous exposure to people who didn't.

[bucolic_frolic]

5. Major illness does change the body

and it is damage. It's like an old broken bone or trauma that twinges in foul weather, never goes away. So I think the answer to your question is yes, though cause of death would probably seen as a secondary incidental disease.

[ananda]

8. Well, it has happened short-term.

So I think it's a definite possibility.

[still_one]

2. That is why there have been some reports that those experiencing a cytokine storm due to

this virus, have found favorable results when given some immuno-suppresives

There is so much unknown about this

[AtheistCrusader]

19. Well, that's true of all cytokine storms.

[Botany]

3. We need a viable vaccine* and Convalescent plasma (CP) therapy**

BTW In the long run this might be good for western nations but the death and illness total
in 3rd world nations might be staggering.

* This MIGHT be good news on vaccines for coronavirus.

Last edited Mon Apr 13, 2020, 04:24 PM - Edit history (1)

https://www.upmc.com/media/news/040220-falo-gambotto-sars-cov2-vaccine

COVID-19 Vaccine Candidate Shows Promise

PITTSBURGH – University of Pittsburgh School of Medicine scientists today announced a potential vaccine against SARS-CoV-2, the new coronavirus causing the COVID-19 pandemic. When tested in mice, the vaccine, delivered through a fingertip-sized patch, produces antibodies specific to SARS-CoV-2 at quantities thought to be sufficient for neutralizing the virus.


The paper appeared today in EBioMedicine, which is published by The Lancet, and is the first study to be published after critique from fellow scientists at outside institutions that describes a candidate vaccine for COVID-19. The researchers were able to act quickly because they had already laid the groundwork during earlier coronavirus epidemics.

snip

The researchers also used a novel approach to deliver the drug, called a microneedle array, to increase potency. This array is a fingertip-sized patch of 400 tiny needles that delivers the spike protein pieces into the skin, where the immune reaction is strongest. The patch goes on like a Band-Aid and then the needles — which are made entirely of sugar and the protein pieces — simply dissolve into the skin.

snip

The system also is highly scalable. The protein pieces are manufactured by a “cell factory” — layers upon layers of cultured cells engineered to express the SARS-CoV-2 spike protein — that can be stacked further to multiply yield. Purifying the protein also can be done at industrial scale. Mass-producing the microneedle array involves spinning down the protein-sugar mixture into a mold using a centrifuge. Once manufactured, the vaccine can sit at room temperature until it’s needed, eliminating the need for refrigeration during transport or storage.

** https://www.lehighvalleylive.com/coronavirus/2020/04/st-lukes-phillipsburg-patient-off-ventilator-after-experimental-covid-19-plasma-trial.html

A COVID-19 patient at St. Luke’s Hospital in Phillipsburg was taken off a ventilator following an experimental blood plasma treatment.

Convalescent plasma, in this case plasma from survivors of COVID-19, is being used to treat seriously ill coronavirus patients. St. Luke’s University Health Network is participating in the convalescent plasma trials as part of a program overseen by the Mayo Clinic.


"It exemplifies the importance of ingenuity and perseverance to support the heroic, life-saving work of our physicians, nurses and other caregivers.” St. Luke’s Warren Campus President Scott R. Wolfe said.

St. Luke’s did not say where the patient was from, or how long they have been hospitalized at the Warren County location.

[mopinko]

10. these are the days of miracle and wonder, this is a long distance call.

not a baby in a bubble or w a baboon heart, but my inner geek can help be hooked on the unfolding amazing discoveries and innovations.
said from day one that if anything could save us, it would be american ingenuity.
and so it seems to be.

scary as fuck here in the land of comorbidity all the same.
in good hands in chicago, tho. much going on here, and we were ready as hell. cook county does public health as well as any county in america.

[ancianita]

16. I hope so.

We're Chicagoans down in Florida where it's not done. We're just undecided about our usual return in June, due to the density of contact risk in Chicago.

It's getting bad because Floridians are so careless (no one in the local Apple repair shop had masks on!) that we might just have to head north anyway.

[SheltieLover]

6. So Lets reopen schools as daycare centers! 🤬🤬🤬🤬🤬

We will likely end up with an entire generation of kids in poor health!

[Ford_Prefect]

7. So thIs is what they mean by collateral damage,eh?

A guaranteed benefit to the health-care industry. Imagine all the extra fees they can run up on the back of one little virus...

Would that be billed under dying for your country, err economy?

[mopinko]

9. yup. that kind of inflammation is like a forest fire.

as a person w auto-immune problems, and 2 kids w ai's, i have watched this closely. i would likely die because i have bad asthma. taking an antihistamine daily just to keep my system quiet.

but i have been completely unsurprised by reports of additional damage this thing is doing. inflammation is the root of cell death in pretty much every disease. kidneys seem an obvious target.

just wait till we see what the post acute phase of this stuff is. i hope it doesnt take 5 docs to get a dx for women in the wake of this, like it took me to get a dx of fibro kicked off by west nile.

this is so very far from over. le sigh.

[SergeStorms]

11. The more I read about this virus...

the more I think "someone" had been genetically modifying it in a laboratory. This is so unlike other corona viruses.

[AtheistCrusader]

20. Please stop. There are obvious markers for all known gene-editing methods humans

have at their disposal. That was one of the first things looked for when the virus's genome was sequenced.

It MAY have escaped a lab where it was being studied, but it would have been evolved, not modified.
This is what viruses DO.

[DBoon]

22. Here is an article supporting natural origins for this virus

https://www.sciencenews.org/article/coronavirus-covid-19-not-human-made-lab-genetic-analysis-nature

The genetic signature looks nothing like what an artificial virus would look like.

[MosheFeingold]

28. The CCP is playing a clever game

Note they say, correctly, there is no evidence the virus was “made” in a lab.

This is to discredit what the evidence points to — a natural virus “released” from a lab.

The market did not sell bats. And it certainly didn’t sell wood bats, which live about 1000 miles away.

The lab, in contrast, did have both the bats and this virus.

AND the lab was a disaster waiting to happen, by all accounts, including, notably CDC Galveston that went and looked at it and urged its closure 2 years ago. (WaPo has this story.)

And now someone has come forward (sadly to Fox) and specifically admitted the accident occurred when a worker was sprayed in the face with blood.

So, remember “escaped” not “made”.

Don’t fall for the spin.

[moriah]

29. Don't fall for the conspiracy theory my Puke senator is pushing, either.

https://www.vanityfair.com/news/2020/04/inside-the-the-viral-spread-of-a-coronavirus-origin-theory

Bill Hanage, associate professor at the Harvard T.H. Chan School of Public Health’s Center for Communicable Disease Dynamics, doesn’t buy it at all. Given the highly elusive nature of SARS-CoV-2, and how we are learning that it causes a lot of minimally symptomatic infections alongside the serious ones that crash health care systems, he said, it strains credulity to imagine that anybody would have extracted it from a bat and actually been able to realize what they were dealing with to the point that it would warrant serious study in a lab for dangerous diseases. It’s also hard for Hanage to believe that any researchers who might have been studying the virus would have understood what it was capable of—in other words, he said, it’s more logical to believe that the new coronavirus was never in a lab in the first place.

“If the first case of this had been anywhere at all in the world, somebody would have found something suspicious nearby,” he said. “If it were in Boston, it would be the National Emerging Infectious Diseases Laboratories. If there is evidence to really support this theory beyond the coincidence of the location of the lab, then I haven’t seen it, and I don’t make decisions on the basis of coincidence.” Hanage’s scientific opinion? “I would probably leave it in the conspiracy theory area.”

[MosheFeingold]

30. He appears to be dancing around the "man-made" theory

Which is EXACTLY the silliness the CCP wants.

It is a fact this virus (and the bats that carried it) were in the lab.

There are plenty of things in this world that are perfectly deadly, but ironically perfectly safe, stuck off in isolated animals around the world.

What happened is some hubritical fools took it from wood bats and isolated it -- and then let it out by incompetence.

[moriah]

31. Are the only possibilities either "unsanitary wet markets" or "let out of a lab"?

I mean, the logic test doesn't pass for it to have originated IN the wet market -- not all the original cases were associated with it, and the cluster being there seems to be more likely evidence of person-to-person transmission from customer to employee and vice-versa.

But just remember the 1918 flu didn't start because of people experimenting on viruses in a lab -- from all available evidence, it started because the US government told every family that could to keep a small flock of chickens, then sent those farmboys who had been exposed to whatever flus might be around their communities or in their community's chickens to petri dishes called military cantonments. They knew that it was a perfect incubator for measles, and the 1918 flu sequencing shows it was clearly an avian influenza.

Honestly, given that precedent, if the wet markets in China are at all linked to this, I'd say Patient Zero was a rural farmer who got infected and was asymptomatic when they took their animals in for sale, and infected others in the city while they were doing the rest of their errands.

[MosheFeingold]

32. So a bat eating farmer

Travels 1000 miles (the closest point) and infects no one along his very public journey, probably trains and buses, and happens to start an infection 400 feet from the lab where the virus has been isolated and being studied?

I’d say that falls under “unlikely”.

A person studying infectious diseases would laugh at us for considering it.

A grave weakness among smart people is to ignore the obvious. Happens because in school we are rewarded by answering with the counterintuitive.

Start with the obvious. Boring. But you’ll stand out for actually being correct.

[moriah]

33. I must require sourcing at this point for several items.

1) Species of bat. a search for -- "wood bat" covid -baseball -- on Google comes up with nothing. And believe me, I tried to eliminate all the baseball related entries for the type of bat you said lives 1000 miles away.

2) Where you're getting that it is not from the intermediate horseshoe bat, which is what most people have said, which has a range certainly chose to Wuhan enough to make the animal farmer raising pangolins and scavenging guano for fertilizer for veggies potentially be a lot closer to the city than you'd think.

------

Sorry but you have discussed this without sources quite a bit, and we are obviously not operating on the same data set, so I apoloigze that I must request links. If you'd rather continue this in PM, feel free to do so.

[MosheFeingold]

34. It's from the articles

About the British government. It’s on this website if you search.

They were the first to call BS on this subspecies of bat being at the wet market.

Now, it turns out this particular wet market had no bat seller that anyone can remember.

[moriah]

35. A search for "wood bat" on this site only comes up with you saying that species.

Aside from baseball posts, at least.

The article linked where you posted and claimed it was a "wood bat" doesn't identify the bat species, just links to the Nature article here, which shows it most similar to specimen Bat COV RaTG13 (from a horseshoe bat).

Yes, the specimen was collected further west, but was also only 96% related (and that's the closest to the SARS-CoV-2 genome).

Still, the range of the intermediate horseshoe bat includes all the farming areas around Wuhan. Which means a farmer/food animal breeder utilizing bat guano as fertilizer is still a major possibility.

[MosheFeingold]

36. Here you go

One duckduckgo search later:

https://www.dailymail.co.uk/news/article-8211257/Wuhan-lab-performing-experiments-bats-coronavirus-caves.html

The genome of the Covid19 virus shows it came from bats in the Yunnan's caves.

This is 803 miles, as the bat flies:

https://www.distancefromto.net/distance-from-yunnan-to-wuhan-cn

As an aside, don't trust corporations with large investments in China: notably ABC (Disney), Google, and a host of others. For whatever reason, they don't seem to be making it easy to find certain information.

[moriah]

37. We're back on the same page -- there is nothing about "wood bats" there.

That is the "horseshoe bat" sample I was speaking of. Rhinolophus affinis. Bat CoV RaTG13 is the most similar virus collected, and yes was among many found in that cave.

And as I showed in my first pretty graphic, the horseshoe bat has a very wide range, including Hubei province. If a 96% similar virus was 803 miles away in a specific cave, the 99% similar one that just hasn't been found yet might have been in Hubei.

Here's another article on China's attempts to study their bats. It discuses how bats come in contact with humans. Guano is a potential vector -- and the free fertilizer is very attractive to poor farmers.

https://www.scientificamerican.com/article/how-chinas-bat-woman-hunted-down-viruses-from-sars-to-the-new-coronavirus1/

[SergeStorms]

26. Thank you....

for putting me in my place.

[Zambero]

12. Systemic

This illness manifests itself in respiratory impacts, although there is mounting evidence that the entire body can be ravaged as well. An effective vaccine can not come soon enough.

[orwell]

13. Once again...

...as I keep saying. We know very little about this virus.

That is why talk about "re-opening" the economy is so dangerous.

We all want things to normalize. But we are far from even contemplating that when we know so little about this disease.

We have proven that social distancing and shelter-in-place works. But that would be true of any disease that transmits through respiratory droplets.

We need to get a handle on the science of this pathogen first before we can plan the road ahead.

That is why this endless stream of bullshit coming from the White House and FauxNoise is such a threat to public safety.

[yaesu]

14. It also damages the T-cells giving it HIV characteristics which lowers the immune system

according to some findings outside the US.

[denem]

15. evil, evil shit,

(almost) unbelievable.

[gordianot]

17. This reminds me of an Uncle who was a test subject in the early 1950's for a Nuclear test.

They put him in a ditch with other Air Force enlisted men. He noted there were no officers in the ditch. In 1968 he finally died body organs shut down. At the time the claim from Dr’s he had Lupus rare in males and there were complications. Odd thing after he died the Veterans Administration requested an autopsy kept the body for 3 days and shipped it out for research. They even told his wife they spent almost a million dollars on the autopsy and the funeral home told her they never saw such a mangled body not in an accident. There was some discussion about a closed casket.

I am not claiming Covid-19 is a conspiracy but there is more to this story.

[calimary]

18. K&R and bookmarking.

[MosheFeingold]

21. It's a blood disease

My son (doctor) has been keeping up with this closely. The virus attacks hemoglobin — which has a double effect of destroying tissue by inflammation from the released iron and effectively suffocating the victim by not transporting oxygen.

The first clue was bilateral pneumonia in a consistent basis. Lung disease doesn’t work that way. It’s usually one lung or the other. Or at least affected unevenly.

As an aside, this is probably why treatments like HCQ have effect - this is very similar to what malaria does. And HCQ is a very power anti inflammatory.

The go-to thinking is HCQ doesn’t do anything to the virus itself — but rather is alleviating the damage so as to allow the body to fight the infection.

For the same reason, vitamin C in massive injection is being used.

[wishstar]

27. Yes and blood thinners heparin and fondaparinux are being used to help Covid patients too

since they are at risk for blood clots

[Mike 03]

23. Question, anybody?

This excerpt:

Even more alarming, he added, is early data that shows 14 to 30 percent of intensive-care patients in New York and Wuhan, China — birthplace of the pandemic — have lost kidney function and require dialysis, or its in-hospital cousin, continuous renal replacement therapy. New York intensive care units are treating so much kidney failure, he said, they need more personnel who can perform dialysis and have issued an urgent call for volunteers from other parts of the country.

Does this mean these patients have permanently lost kidney function and will have to live on dialysis for the rest of their lives, or is this a temporary state?

[rockfordfile]

24. What about mild conditions?

[riversedge]

25. k and R