Biden Officials Now Expect Vulnerable Americans to Need Booster Shots
Source: New York Times
WASHINGTON Biden administration health officials increasingly think that vulnerable populations will need booster shots even as research continues into how long the coronavirus vaccines remain effective. Senior officials now say they expect that people who are 65 and older or who have compromised immune systems will most likely need a third shot from Pfizer-BioNTech or Moderna, two vaccines based on the same technology that have been used to inoculate the vast majority of Americans thus far.
That is a sharp shift from just a few weeks ago, when the administration said it thought there was not enough evidence to back boosters yet.On Thursday, a key official at the Centers for Disease Control and Prevention said the agency is exploring options to give patients with compromised immune systems third doses even before regulators broaden the emergency use authorization for coronavirus vaccines, a step that could come soon for the Pfizer vaccine.
Dr. Amanda Cohn, the chief medical officer of the C.D.C.s immunizations division, told an advisory committee to the agency that officials were actively looking into ways to provide certain people access to booster shots earlier than any potential change in regulatory decisions. So stay tuned, she added. The growing consensus within the administration that at least some Americans will need a booster is tied in part to research suggesting that the Pfizer vaccine is less effective against the coronavirus after about six months. More than half of those fully vaccinated in the United States so far have received Pfizers vaccine, in two doses administered three weeks apart.
Pfizers continuing global study of its clinical trial participants shows that four to six months after the second dose, the vaccines effectiveness against symptomatic infection drops from a high of 95 percent to 84 percent, according to the company. Data from the Israeli government, which has fully vaccinated more than half of its population with Pfizer doses since January, also points to a downward trend in effectiveness over time, although administration officials are viewing that data cautiously because of wide margins for error.
Read more: https://www.nytimes.com/2021/07/23/us/covid-vaccine-boosters.html
Must be the Friday night news dump.
liberal N proud
(60,332 posts)murielm99
(30,715 posts)ananda
(28,833 posts)No fuckin around with this virus.
Hortensis
(58,785 posts)in a country where all that's required is accepting free, available vaccinations. Billions elsewhere can only wait and hope.
Rorey
(8,445 posts)At this point, I don't seem to have a compromised immune system, but if a booster is safe, effective and available, I see no reason not to get one.
NewHendoLib
(60,006 posts)I_UndergroundPanther
(12,462 posts)Moderna needs a booster shot.
If so I will be in line as soon as those with multiple risk factors get the booster.
I have 3 risk factors.
So I am a little tweaky.
LisaL
(44,972 posts)So if Pfizer needs a booster, Moderna will almost certainly need a booster.
I got Moderna also. So I expect booster will be needed.
BumRushDaShow
(128,438 posts)(and also got Moderna)
BumRushDaShow
(128,438 posts)and like Pfizer, has their booster in a trial right now (and are also including looking at mixing different vaccines).
https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-positive-initial-booster-data-against-sars-cov
winstars
(4,219 posts)monkeyman1
(5,109 posts)Tess49
(1,579 posts)monkeyman1
(5,109 posts)Tess49
(1,579 posts)Hekate
(90,550 posts)aocommunalpunch
(4,232 posts)I honestly don't remember how the initial vaccines were paid for.
LisaL
(44,972 posts)They've already purchased enough Pfizer and Moderna to boost everyone who wants it as far as I can tell.
wnylib
(21,331 posts)to people who get them, like the first two shots were?
Mr.Bill
(24,236 posts)I have a great deal of confidence in her. She is an internist and is the director of the medical clinic affiliated with our local hospital. When the Moderna vaccine first became available in January I didn't call for an appointment. Her office called me and told me when my appointment was, and asked if that was convenient. I'm sure they will do the same for the booster. It pays, at my age, to have a continuing relationship with a primary care physician with annual physicals.
DonCoquixote
(13,616 posts)if nothing else, I want to outlast the people whose stupidity caused this
Gore1FL
(21,097 posts)orleans
(34,040 posts)"Johnson & Johnsons one-shot vaccine has so far played a minor role in the nations vaccination campaign. Clinical trial data on how that vaccine works with two shots is expected next month."
herding cats
(19,558 posts)There are studies taking place now. J&J as a follow up for mRNA as a booster and vice versa.
Studies are currently being done on both.
orleans
(34,040 posts)BumRushDaShow
(128,438 posts)Aussie105
(5,318 posts)and I'm not liking the 12 week wait in between that and the second.
I'm all in favor of a booster, of any sort, sometime after the second AstraZ, if the Science requires it to enhance protection.
Maybe an annual brew of flu and covid vaccines?
BumRushDaShow
(128,438 posts)They are already looking at something like that here...
The Novavax makers did a small study of that - https://www.webmd.com/vaccines/covid-19-vaccine/news/20210617/combining-covid-flu-shots-appears-safe-and-effective
Novavax hasn't applied for an EUA yet though (possibly in the fall).
Moderna just started a trial with an mRNA flu vaccine that if it works, could allow creating such a combination shot much easier - https://www.forbes.com/sites/jemimamcevoy/2021/07/07/moderna-begins-human-study-of-mrna-based-flu-shot-after-covid-success/?sh=ef68e9064c9a
wnylib
(21,331 posts)I could finally get one. I am allergic to the regular flu vaccine.
BumRushDaShow
(128,438 posts)Instead of using either weakened live, dead, or viral fragments, you actually "train" your immune system to recognize certain characteristics of the target virus by modifying your own cells to "look like" them temporarily. That keeps extra substrates out of the vaccine that could cause an allergic reaction.
JudyM
(29,187 posts)Hopefully well start seeing more folks masking.
I was hoping this was coming, based on the Israeli data, even if the MoE was broad. We cant close our eyes and hope for the best when we can easily take an extra precaution.
MrModerate
(9,753 posts)people like me (over 65 but healthy) get a third dose.
It just doesn't seem right, or wise.
LisaL
(44,972 posts)US lost over 600,000 people to covid so far. Should we lose 600,000 more?
MrModerate
(9,753 posts)The human race as a whole (including Americans) will never get past this thing.
BumRushDaShow
(128,438 posts)is the lack of infrastructure to store them (particularly the large batches needing ultra-low freezers) and the logistics to get them distributed. That was actually a problem (and is still one to a degree) in the rural areas in the U.S.
It's only been in the past 2 months (since May) when, for example, the Pfizer vaccine (based on stability/efficacy testing) was authorized to be stored in a thawed/undiluted condition for up to a month at normal refrigerator temperatures - https://www.npr.org/sections/coronavirus-live-updates/2021/05/19/998420256/pfizer-vaccine-can-stay-longer-at-warmer-temperatures-before-being-discarded
uppityperson
(115,677 posts)Getting them at least one vx will help prevent deaths. The vast majority of vxd people getting covid do not get sick enough to need hospitalization.
LisaL
(44,972 posts)we can use their doses for boosters.
wnylib
(21,331 posts)the most vulnerable people, not for everyone.
uppityperson
(115,677 posts)turbinetree
(24,683 posts)BumRushDaShow
(128,438 posts)to test mixed vaccine usage by those vaccinated with any of the 3 currently approved (J&J, Pfizer or Moderna), where they will be given Moderna as a booster - https://www.nih.gov/news-events/news-releases/nih-clinical-trial-evaluating-mixed-covid-19-vaccine-schedules-begins
So the trials would be looking at -
J&J (1 dose) + Moderna (booster)
Pfizer (2 doses) + Moderna (booster)
Moderna (2 doses) + Moderna (booster)
I know Janssen (J&J) had been considering looking at a 2-dose regime early on, but then seemed to want to stick with an "ease of use but still highly effective" strategy... And then other issues popped up, along with Delta, and that probably has them re-thinking next steps.
turbinetree
(24,683 posts)looks like from what is being said that Moderna will be the go to booster...now its a wait and see phase....
BumRushDaShow
(128,438 posts)I am guessing since NIH was involved with developing Moderna, that is what they have expertise in and probably what they wanted to try in a trial.
Pfizer, by far, has been the most distributed vaccine in the U.S. in any case due to them being first with authorization, and having a significant number of doses ready to go, but I expect the 2 could be interchangeable for a booster.
ETA - I had seen some articles where some people with J&J were seeing out their own boosters - https://www.usnews.com/news/health-news/articles/2021-07-01/reports-of-some-getting-pfizer-moderna-boosters-after-j-j-vaccine-prompts-calls-for-more-guidance
So although obviously not "authorized" for off-label use (mixed vaccines/boosters), some are going ahead with their own trialing.
lapucelle
(18,187 posts)Premiering Sunday, February 21 at 8 PM PT/ET on Discovery
(NEW YORK) What does it take to create a vaccine in record time to once and for all eradicate a global pandemic? What measures are in place to ensure its safety? And how did the worlds leading doctors and healthcare experts develop it? Today, Discovery announced a timely special, THE VACCINE: CONQUERING COVID premiering Sunday, February 21 at 8 PM PT/ET on Discovery and streaming on discovery+.
https://press.discovery.com/us/dsc/programs/vaccine-conquering-covid/
The Discovery Channel recently aired the documentary The Vaccine: Conquering Covid, which chronicles the development of Covid-19 vaccines over the past year.
The documentary featured interviews with several members of NIH, including NIH director Dr. Francis Collins, NIAID director Dr. Anthony Fauci, Vaccine Research Center director Dr. John Mascola and VRC coronavirus vaccine lead Dr. Kizzmekia Corbett. Several clinical trial volunteers also share their experiences.
https://nihrecord.nih.gov/2021/04/02/discovery-channel-airs-vaccine-conquering-covid
BumRushDaShow
(128,438 posts)I had heard about it but never got chance to check it out. Discovery has a streaming option to watch those episodes (if you have eligible cable service) so I have it bookmarked!
llashram
(6,265 posts)science, until I can't...
locks
(2,012 posts)When I wrote to the doctor about booster shots they said they were keeping on top of all the info but did not think they would be necessary. I wrote back asking them to read the NYTimes article.
BumRushDaShow
(128,438 posts)is that many medical and scientific personnel are pretty much stuck making decisions based on their knowledge of how "typical" respiratory viruses behave - particularly the various flus.
This is why they keep failing over and over and over, because despite calling COVID-19 "novel", in reality they hesitate believing it is "novel", and refuse to accept that there is a definite predictability that it will be unpredictable. This is why they are unable to quickly pivot their recommendations to deal with it.