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BumRushDaShow

(128,438 posts)
Fri Jul 23, 2021, 08:17 PM Jul 2021

Biden Officials Now Expect Vulnerable Americans to Need Booster Shots

Source: New York Times

WASHINGTON — Biden administration health officials increasingly think that vulnerable populations will need booster shots even as research continues into how long the coronavirus vaccines remain effective. Senior officials now say they expect that people who are 65 and older or who have compromised immune systems will most likely need a third shot from Pfizer-BioNTech or Moderna, two vaccines based on the same technology that have been used to inoculate the vast majority of Americans thus far.

That is a sharp shift from just a few weeks ago, when the administration said it thought there was not enough evidence to back boosters yet.On Thursday, a key official at the Centers for Disease Control and Prevention said the agency is exploring options to give patients with compromised immune systems third doses even before regulators broaden the emergency use authorization for coronavirus vaccines, a step that could come soon for the Pfizer vaccine.

Dr. Amanda Cohn, the chief medical officer of the C.D.C.’s immunizations division, told an advisory committee to the agency that officials were “actively looking into ways” to provide certain people access to booster shots “earlier than any potential change in regulatory decisions.” “So stay tuned,” she added. The growing consensus within the administration that at least some Americans will need a booster is tied in part to research suggesting that the Pfizer vaccine is less effective against the coronavirus after about six months. More than half of those fully vaccinated in the United States so far have received Pfizer’s vaccine, in two doses administered three weeks apart.

Pfizer’s continuing global study of its clinical trial participants shows that four to six months after the second dose, the vaccine’s effectiveness against symptomatic infection drops from a high of 95 percent to 84 percent, according to the company. Data from the Israeli government, which has fully vaccinated more than half of its population with Pfizer doses since January, also points to a downward trend in effectiveness over time, although administration officials are viewing that data cautiously because of wide margins for error.

Read more: https://www.nytimes.com/2021/07/23/us/covid-vaccine-boosters.html



Must be the Friday night news dump.
48 replies = new reply since forum marked as read
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Biden Officials Now Expect Vulnerable Americans to Need Booster Shots (Original Post) BumRushDaShow Jul 2021 OP
If and when a booster is necessary, I will get in line liberal N proud Jul 2021 #1
I will be right behind you. murielm99 Jul 2021 #3
Same. ananda Jul 2021 #23
Right. Just let us know when and where. Thank goodness we live Hortensis Jul 2021 #42
I'll do whatever I need to do Rorey Jul 2021 #2
continuing research and science always lead to changes. I will happily get the booster. NewHendoLib Jul 2021 #4
I wonder if I_UndergroundPanther Jul 2021 #5
Moderna and Pfizer are very similar vaccines. LisaL Jul 2021 #6
Jinx! BumRushDaShow Jul 2021 #8
I know Moderna had already been working on one too BumRushDaShow Jul 2021 #7
Bring it on... I am good to go, follow the science... winstars Jul 2021 #9
everybody need's too ! i'm good to go too !! monkeyman1 Jul 2021 #12
I will cheerfully get in line for a booster. No reason not to if it's needed. Tess49 Jul 2021 #10
got both m's & i'm doing what they say ! no questions asked !! monkeyman1 Jul 2021 #11
Exactly! Tess49 Jul 2021 #33
Take a number and line up. I'll be there. Hekate Jul 2021 #13
Who's paying for it? aocommunalpunch Jul 2021 #14
Government is buying the vaccines. LisaL Jul 2021 #15
But will the boosters be free wnylib Jul 2021 #43
I will follow the advice of my primary care physician. Mr.Bill Jul 2021 #16
count me in line DonCoquixote Jul 2021 #17
I'll take a shot every month if that's what it takes. nt Gore1FL Jul 2021 #18
and for those J&J folks... orleans Jul 2021 #19
Also, there's buzz (from my doctors) mRNA vaccine follow up for J&J may be good. herding cats Jul 2021 #20
that's interesting. nt orleans Jul 2021 #21
I posted upthread about that booster/mixed-vaccines trial BumRushDaShow Jul 2021 #22
Wife and I have had the first AstraZ shot Aussie105 Jul 2021 #24
"Maybe an annual brew of flu and covid vaccines?" BumRushDaShow Jul 2021 #25
mRNA flu vaccine would mean that wnylib Jul 2021 #44
Yes - that would definitely be a benefit BumRushDaShow Jul 2021 #46
This is also a warning to be more careful the farther out we are from our last vaccination. JudyM Jul 2021 #26
Sure hope they can get vaccines out to the rest of the world before... MrModerate Jul 2021 #27
How exactly does it not seem right? LisaL Jul 2021 #28
As a practical matter, if we don't reduce the variant factories in low-vaccination countries... MrModerate Jul 2021 #29
One of the problems with vaccines in other countries BumRushDaShow Jul 2021 #30
There are 20 countries with a higher death rate than the usa, many with fewer vxd people uppityperson Jul 2021 #37
Since half the country won't vaccinate, LisaL Jul 2021 #40
True. Also, the boosters are being targeted for wnylib Jul 2021 #45
I agree, otherwise it's like wiping the bathroom floor with a cloth while the taps are wide open uppityperson Jul 2021 #38
And so what about the J&J people? turbinetree Jul 2021 #31
There are trials including one BumRushDaShow Jul 2021 #34
Thank you...for this turbinetree Jul 2021 #35
You are welcome! BumRushDaShow Jul 2021 #36
I saw a great documentary on the development of the Moderna vaccine on the Discovery Channel. lapucelle Jul 2021 #39
Thanks for the link to that! BumRushDaShow Jul 2021 #41
I will trust llashram Jul 2021 #32
I belong to Kaiser Permanente locks Jul 2021 #47
I think part of the problem BumRushDaShow Jul 2021 #48

Hortensis

(58,785 posts)
42. Right. Just let us know when and where. Thank goodness we live
Sat Jul 24, 2021, 04:34 PM
Jul 2021

in a country where all that's required is accepting free, available vaccinations. Billions elsewhere can only wait and hope.

Rorey

(8,445 posts)
2. I'll do whatever I need to do
Fri Jul 23, 2021, 08:29 PM
Jul 2021

At this point, I don't seem to have a compromised immune system, but if a booster is safe, effective and available, I see no reason not to get one.

I_UndergroundPanther

(12,462 posts)
5. I wonder if
Fri Jul 23, 2021, 09:43 PM
Jul 2021

Moderna needs a booster shot.

If so I will be in line as soon as those with multiple risk factors get the booster.

I have 3 risk factors.

So I am a little tweaky.

LisaL

(44,972 posts)
6. Moderna and Pfizer are very similar vaccines.
Fri Jul 23, 2021, 09:50 PM
Jul 2021

So if Pfizer needs a booster, Moderna will almost certainly need a booster.
I got Moderna also. So I expect booster will be needed.

LisaL

(44,972 posts)
15. Government is buying the vaccines.
Sat Jul 24, 2021, 12:30 AM
Jul 2021

They've already purchased enough Pfizer and Moderna to boost everyone who wants it as far as I can tell.

Mr.Bill

(24,236 posts)
16. I will follow the advice of my primary care physician.
Sat Jul 24, 2021, 12:35 AM
Jul 2021

I have a great deal of confidence in her. She is an internist and is the director of the medical clinic affiliated with our local hospital. When the Moderna vaccine first became available in January I didn't call for an appointment. Her office called me and told me when my appointment was, and asked if that was convenient. I'm sure they will do the same for the booster. It pays, at my age, to have a continuing relationship with a primary care physician with annual physicals.

orleans

(34,040 posts)
19. and for those J&J folks...
Sat Jul 24, 2021, 02:06 AM
Jul 2021

"Johnson & Johnson’s one-shot vaccine has so far played a minor role in the nation’s vaccination campaign. Clinical trial data on how that vaccine works with two shots is expected next month."

herding cats

(19,558 posts)
20. Also, there's buzz (from my doctors) mRNA vaccine follow up for J&J may be good.
Sat Jul 24, 2021, 02:24 AM
Jul 2021

There are studies taking place now. J&J as a follow up for mRNA as a booster and vice versa.

Studies are currently being done on both.

Aussie105

(5,318 posts)
24. Wife and I have had the first AstraZ shot
Sat Jul 24, 2021, 08:31 AM
Jul 2021

and I'm not liking the 12 week wait in between that and the second.

I'm all in favor of a booster, of any sort, sometime after the second AstraZ, if the Science requires it to enhance protection.

Maybe an annual brew of flu and covid vaccines?

BumRushDaShow

(128,438 posts)
25. "Maybe an annual brew of flu and covid vaccines?"
Sat Jul 24, 2021, 08:40 AM
Jul 2021

They are already looking at something like that here...

The Novavax makers did a small study of that - https://www.webmd.com/vaccines/covid-19-vaccine/news/20210617/combining-covid-flu-shots-appears-safe-and-effective

Novavax hasn't applied for an EUA yet though (possibly in the fall).

Moderna just started a trial with an mRNA flu vaccine that if it works, could allow creating such a combination shot much easier - https://www.forbes.com/sites/jemimamcevoy/2021/07/07/moderna-begins-human-study-of-mrna-based-flu-shot-after-covid-success/?sh=ef68e9064c9a

BumRushDaShow

(128,438 posts)
46. Yes - that would definitely be a benefit
Sat Jul 24, 2021, 08:18 PM
Jul 2021

Instead of using either weakened live, dead, or viral fragments, you actually "train" your immune system to recognize certain characteristics of the target virus by modifying your own cells to "look like" them temporarily. That keeps extra substrates out of the vaccine that could cause an allergic reaction.

JudyM

(29,187 posts)
26. This is also a warning to be more careful the farther out we are from our last vaccination.
Sat Jul 24, 2021, 09:36 AM
Jul 2021

Hopefully we’ll start seeing more folks masking.

I was hoping this was coming, based on the Israeli data, even if the MoE was broad. We can’t close our eyes and hope for the best when we can easily take an extra precaution.

 

MrModerate

(9,753 posts)
27. Sure hope they can get vaccines out to the rest of the world before...
Sat Jul 24, 2021, 10:05 AM
Jul 2021

people like me (over 65 but healthy) get a third dose.

It just doesn't seem right, or wise.

LisaL

(44,972 posts)
28. How exactly does it not seem right?
Sat Jul 24, 2021, 10:12 AM
Jul 2021

US lost over 600,000 people to covid so far. Should we lose 600,000 more?

 

MrModerate

(9,753 posts)
29. As a practical matter, if we don't reduce the variant factories in low-vaccination countries...
Sat Jul 24, 2021, 10:20 AM
Jul 2021

The human race as a whole (including Americans) will never get past this thing.

BumRushDaShow

(128,438 posts)
30. One of the problems with vaccines in other countries
Sat Jul 24, 2021, 10:37 AM
Jul 2021

is the lack of infrastructure to store them (particularly the large batches needing ultra-low freezers) and the logistics to get them distributed. That was actually a problem (and is still one to a degree) in the rural areas in the U.S.

It's only been in the past 2 months (since May) when, for example, the Pfizer vaccine (based on stability/efficacy testing) was authorized to be stored in a thawed/undiluted condition for up to a month at normal refrigerator temperatures - https://www.npr.org/sections/coronavirus-live-updates/2021/05/19/998420256/pfizer-vaccine-can-stay-longer-at-warmer-temperatures-before-being-discarded

uppityperson

(115,677 posts)
37. There are 20 countries with a higher death rate than the usa, many with fewer vxd people
Sat Jul 24, 2021, 02:57 PM
Jul 2021

Getting them at least one vx will help prevent deaths. The vast majority of vxd people getting covid do not get sick enough to need hospitalization.

BumRushDaShow

(128,438 posts)
34. There are trials including one
Sat Jul 24, 2021, 12:47 PM
Jul 2021

to test mixed vaccine usage by those vaccinated with any of the 3 currently approved (J&J, Pfizer or Moderna), where they will be given Moderna as a booster - https://www.nih.gov/news-events/news-releases/nih-clinical-trial-evaluating-mixed-covid-19-vaccine-schedules-begins

So the trials would be looking at -

J&J (1 dose) + Moderna (booster)
Pfizer (2 doses) + Moderna (booster)
Moderna (2 doses) + Moderna (booster)

I know Janssen (J&J) had been considering looking at a 2-dose regime early on, but then seemed to want to stick with an "ease of use but still highly effective" strategy... And then other issues popped up, along with Delta, and that probably has them re-thinking next steps.

turbinetree

(24,683 posts)
35. Thank you...for this
Sat Jul 24, 2021, 01:16 PM
Jul 2021

looks like from what is being said that Moderna will be the go to booster...now its a wait and see phase....

BumRushDaShow

(128,438 posts)
36. You are welcome!
Sat Jul 24, 2021, 02:21 PM
Jul 2021

I am guessing since NIH was involved with developing Moderna, that is what they have expertise in and probably what they wanted to try in a trial.

Pfizer, by far, has been the most distributed vaccine in the U.S. in any case due to them being first with authorization, and having a significant number of doses ready to go, but I expect the 2 could be interchangeable for a booster.

ETA - I had seen some articles where some people with J&J were seeing out their own boosters - https://www.usnews.com/news/health-news/articles/2021-07-01/reports-of-some-getting-pfizer-moderna-boosters-after-j-j-vaccine-prompts-calls-for-more-guidance

So although obviously not "authorized" for off-label use (mixed vaccines/boosters), some are going ahead with their own trialing.

lapucelle

(18,187 posts)
39. I saw a great documentary on the development of the Moderna vaccine on the Discovery Channel.
Sat Jul 24, 2021, 03:51 PM
Jul 2021
The Vaccine: Conquering COVID

Premiering Sunday, February 21 at 8 PM PT/ET on Discovery

(NEW YORK) – What does it take to create a vaccine in record time to once and for all eradicate a global pandemic? What measures are in place to ensure its safety? And how did the world’s leading doctors and healthcare experts develop it? Today, Discovery announced a timely special, THE VACCINE: CONQUERING COVID premiering Sunday, February 21 at 8 PM PT/ET on Discovery and streaming on discovery+.

https://press.discovery.com/us/dsc/programs/vaccine-conquering-covid/

Discovery Channel Airs The Vaccine: Conquering Covid

The Discovery Channel recently aired the documentary The Vaccine: Conquering Covid, which chronicles the development of Covid-19 vaccines over the past year.

The documentary featured interviews with several members of NIH, including NIH director Dr. Francis Collins, NIAID director Dr. Anthony Fauci, Vaccine Research Center director Dr. John Mascola and VRC coronavirus vaccine lead Dr. Kizzmekia Corbett. Several clinical trial volunteers also share their experiences.

https://nihrecord.nih.gov/2021/04/02/discovery-channel-airs-vaccine-conquering-covid

BumRushDaShow

(128,438 posts)
41. Thanks for the link to that!
Sat Jul 24, 2021, 04:27 PM
Jul 2021

I had heard about it but never got chance to check it out. Discovery has a streaming option to watch those episodes (if you have eligible cable service) so I have it bookmarked!

locks

(2,012 posts)
47. I belong to Kaiser Permanente
Sat Jul 24, 2021, 10:11 PM
Jul 2021

When I wrote to the doctor about booster shots they said they were keeping on top of all the info but did not think they would be necessary. I wrote back asking them to read the NYTimes article.

BumRushDaShow

(128,438 posts)
48. I think part of the problem
Sun Jul 25, 2021, 05:36 AM
Jul 2021

is that many medical and scientific personnel are pretty much stuck making decisions based on their knowledge of how "typical" respiratory viruses behave - particularly the various flus.

This is why they keep failing over and over and over, because despite calling COVID-19 "novel", in reality they hesitate believing it is "novel", and refuse to accept that there is a definite predictability that it will be unpredictable. This is why they are unable to quickly pivot their recommendations to deal with it.

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