Johnson & Johnson booster shot prompts large increase in immune response, company says

[nitpicker]

Source: CNN

(CNN)Booster doses of Johnson & Johnson's one-shot coronavirus vaccine generated a big spike in antibodies, the frontline immune system defenses against infection, the company reported Wednesday.

People who received a booster six to eight months after their initial J&J shots saw antibodies increase nine-fold higher than 28 days after the first shot, Johnson & Johnson said.

The data comes from two Phase 2 studies conducted in the United States and Europe, the company said in a statement. Some of the 2,000 or so people in the studies got booster doses six months after their first doses of J&J's Janssen vaccine.
(snip)

Read more: https://www.cnn.com/2021/08/25/health/johnson-vaccine-booster-data/index.html

[janterry]

1. The long lag between shots might be a big help

I've seen some data that suggests that the lag time in the mRNA shots in different countries produced different effects (longer time in England, for instance, suggested somewhat better outcomes than in the US - where we gave the shots out, typically, in a shorter timeframe).

Have NOT seen that as an empirical study - just some prelim. data. I think it's worthy of deeper analysis. If true - J&J would benefit from that (again, perhaps)

[mopinko]

2. always did find that a bit sketchy.

better 1 jab than none, but...

[FarPoint]

3. He is a link to explain the composition difference...

https://www.vcuhealth.org/news/covid-19/johnson-and-johnson-vaccine-how-is-it-different


snip>

The ultimate difference is the way the instructions are delivered. The Moderna and Pfizer vaccines use mRNA technology, and the Johnson & Johnson vaccine uses the more traditional virus-based technology. mRNA is essentially a little piece of code that the vaccine delivers to your cells. The code serves as an instruction manual for your immune system, teaching it to recognize the virus that causes COVID-19 and attack it, should it encounter the real thing.

Instead of using mRNA, the Johnson & Johnson vaccine uses a disabled adenovirus to deliver the instructions. This adenovirus is in no way related to the coronavirus. It is a completely different virus. Although it can deliver the instructions on how to defeat the coronavirus, it can’t replicate in your body and will not give you a viral infection. end>

[honest.abe]

4. I hope this gets approved.

It seems to make sense for those of us who got the J&J vax.

[Auggie]

5. K&R -- thanks for sharing!

[Mysterian]

6. Great news!

Thanks to the smart folks who develop these vaccines!

[Midnight Writer]

7. Finally, a little love for the J&J.

I was starting to fear I had bet on a dead horse.

[hibbing]

8. I'll be waiting for this

Back when my workplace was offering vaccinations, we did not really have a choice, some people got the two shot, some got the one shot. I got the one shot and have been curious because I have not seen anything about the booster for the J & J.

Thanks for posting this.

Peace

[slightlv]

9. What about mixing the shots?

Hubby and I got the Moderna shot back in Feb. Has there been empirical studies regarding the efficacy of shots where the first set was of the MRna and the booster was of the more commonly delivered J&J?

IOW, if the initial shot(s) were of one type, does the booster have to be of the same type (and/or company's)?

Also, there has been a lot of talk and study of immunocompromised individuals... but what about those of us who have whacked out immune systems... as in auto-immune diseases. Does mixing the shots... or even getting the booster... increase the danger of our immune systems attacking our own organs to a greater degree?

I'm absolutely all for the shots and boosters. We're fully immunized, as are all our family and the friends we associate with. But there are several of us with different types of autoimmune diseases in the group. I have lupus; one has MS; another has Hashimoto's disease, eg.

We'll get the booster, to be sure. Just would like some of our questions answered so we can feel better about it going in.

[Deminpenn]

11. Our local health system's info on Covid19 boosters

says you can get either although Fauci has said you should stick with the one you got for the 1st two shots.

[slightlv]

17. Thank you for the information! nt

[Deminpenn]

18. Here is the link and relevent quote

https://myemail.constantcontact.com/Heritage-Valley-E-Connections---August-20--2021.html?soid=1117303718390&aid=f6cEadukP1E

If you qualify for the booster vaccine dose, the CDC recommends waiting at least 28 days after receiving your second dose of the Pfizer or Moderna vaccine. It is preferable that you receive the same dose (Pfizer or Moderna), but doses can be mixed if your original vaccine is no longer available to you. It is not necessary for your third dose to be administered at the same location as your original vaccines.

[Grasswire2]

10. I got the J&J, and now I have learned more.

I did not know that about the distinction between the MRNA and the adenovirus basis of the J&J. I'm happy and will look forward to the booster J&J.

[madville]

13. That's why I picked the J&J vaccine originally

Since it was made/delivered via more traditional and proven vaccine technology I felt better about it. I was kinda skeptical about the Pfizer/Moderna mRNA technology a year ago but not so much today of course, today I would get any of them.

[madville]

12. Good news, will probably get a J&J booster in October then

Got my original in April.

[orleans]

16. same here nt

[riversedge]

14. Good news. One more piece to fight the Covid.

[StarryNite]

15. Good to hear they are doing testing on J&J.

I'm going to be following the scientific recommendations when they come out.

"Federal health officials have said they believe a booster dose of the Janssen vaccine will be needed at some point."

I'm waiting to see what timeframe the scientific community that is studying the J&J says is the "point" to get a booster.

[roamer65]

19. Start lining em up.

At a safe distance between them, of course.