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IDemo

(16,926 posts)
Sun Oct 12, 2014, 08:02 PM Oct 2014

Breakthrough Replicates Human Brain Cells for Use in Alzheimer’s Research

Source: New York Times

For the first time, and to the astonishment of many of their colleagues, researchers created what they call Alzheimer’s in a Dish — a petri dish with human brain cells that develop the telltale structures of Alzheimer’s disease. In doing so, they resolved a longstanding problem of how to study Alzheimer’s and search for drugs to treat it; the best they had until now were mice that developed an imperfect form of the disease.

The key to their success, said the lead researcher, Rudolph E. Tanzi of Massachusetts General Hospital in Boston, was a suggestion by his colleague Doo Yeon Kim to grow human brain cells in a gel, where they formed networks as in an actual brain. They gave the neurons genes for Alzheimer’s disease. Within weeks they saw the hard Brillo-like clumps known as plaques and then the twisted spaghetti-like coils known as tangles — the defining features of Alzheimer’s disease.

The work, which also offers strong support for an old idea about how the disease progresses, was published in Nature on Sunday. Leading researchers said it should have a big effect.

“It is a giant step forward for the field,” said Dr. P. Murali Doraiswamy, an Alzheimer’s researcher at Duke University. “It could dramatically accelerate testing of new drug candidates.”

Read more: http://www.nytimes.com/2014/10/13/science/researchers-replicate-alzheimers-brain-cells-in-a-petri-dish.html?_r=0

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Breakthrough Replicates Human Brain Cells for Use in Alzheimer’s Research (Original Post) IDemo Oct 2014 OP
Wow! That's pretty exciting news! nt scarletwoman Oct 2014 #1
Good breakthrough. sheshe2 Oct 2014 #2
I'm right there with you... Javaman Oct 2014 #21
A photo fading away, so true Javaman. nt sheshe2 Oct 2014 #27
It is sad Faux pas Oct 2014 #26
Thank you for the healing vibes Faux pas. sheshe2 Oct 2014 #28
You're welcome for sure Faux pas Oct 2014 #29
Fantastic news! Plucketeer Oct 2014 #3
The GOP House will slash funding as soon as they can. RoverSuswade Oct 2014 #16
Hurry. joanbarnes Oct 2014 #4
"Pro-life" whingers in 3... 2... 1... DRoseDARs Oct 2014 #5
This is great news, hopefully research can soon make a difference. Thinkingabout Oct 2014 #6
How bout Republicans? GeorgeGist Oct 2014 #7
It is not possible to grow Republican brain cells Thor_MN Oct 2014 #14
Not so sure about that. Marie Marie Oct 2014 #15
If you held the crap up to your ear packman Oct 2014 #22
Sure you can. Rozlee Oct 2014 #18
Growing Republican brain cells is like making Unicorn stew. Thor_MN Oct 2014 #30
Click the link FREE everyday to help fund research Omaha Steve Oct 2014 #8
Thanks for the link Steve. sheshe2 Oct 2014 #9
The brain is way more complex than a petri dish with gel. NoodleyAppendage Oct 2014 #10
Yes, but it's a lot easier to get a new one. jeff47 Oct 2014 #11
You cannot have a workable model without all variables NoodleyAppendage Oct 2014 #24
Sure you can. How do you think we developed every single drug? jeff47 Oct 2014 #25
Fantastic tiptonic Oct 2014 #12
K & R Iliyah Oct 2014 #13
I'm alot more concerned about Alzheimer’s than Ebola...at least for now KinMd Oct 2014 #17
Michelle Bachman will now claim scientists are breeding human brains in dishes.... Spitfire of ATJ Oct 2014 #19
Super good news on this madokie Oct 2014 #20
Good news! tweeternik Oct 2014 #23

sheshe2

(83,745 posts)
2. Good breakthrough.
Sun Oct 12, 2014, 08:14 PM
Oct 2014

I hope that the testing and research pay off. It is painful to see your parent fade away from you from this disease. I have been watching it first hand for several years.

Javaman

(62,517 posts)
21. I'm right there with you...
Mon Oct 13, 2014, 10:10 AM
Oct 2014

My mom had it.

It's painful to witness.

it's like watching a photo fade away.

Faux pas

(14,667 posts)
26. It is sad
Mon Oct 13, 2014, 11:52 AM
Oct 2014

I watched my mom fade away for 12 years before it killed her. My best dealing and healing vibes to you.

 

Plucketeer

(12,882 posts)
3. Fantastic news!
Sun Oct 12, 2014, 08:17 PM
Oct 2014

Of course, those that dismiss "science" won't need whatever voodoo comes of this. God'll cure 'em!

 

DRoseDARs

(6,810 posts)
5. "Pro-life" whingers in 3... 2... 1...
Sun Oct 12, 2014, 08:36 PM
Oct 2014

Something something fetus something playing God something something argle-bargle something Benghazi.

Thinkingabout

(30,058 posts)
6. This is great news, hopefully research can soon make a difference.
Sun Oct 12, 2014, 08:36 PM
Oct 2014

The whole family suffers along with the patient.

Marie Marie

(9,999 posts)
15. Not so sure about that.
Sun Oct 12, 2014, 10:10 PM
Oct 2014

I just found some funky crap in my refrigerator - all covered in some hairy mold that I swear could double for Repub brain cells.

 

packman

(16,296 posts)
22. If you held the crap up to your ear
Mon Oct 13, 2014, 10:36 AM
Oct 2014

and could hear the phrase,"Benghazi" it was Republican brain cells.

Rozlee

(2,529 posts)
18. Sure you can.
Mon Oct 13, 2014, 02:04 AM
Oct 2014

You can do like they did on that Star Trek movie, when they combined a human with the mind of a Voyager satellite. Just hook up their brain cells to the main Fox News satellites and let 'em rip. You'll create the most ignorant species of borgs in the entire cosmos.

 

Thor_MN

(11,843 posts)
30. Growing Republican brain cells is like making Unicorn stew.
Mon Oct 13, 2014, 05:50 PM
Oct 2014

The first step is catch a Unicorn...

sheshe2

(83,745 posts)
9. Thanks for the link Steve.
Sun Oct 12, 2014, 08:51 PM
Oct 2014

I bookmarked the thread so that I can click it everyday. My dad suffers from Alzheimer as does the family that watches him fade.

NoodleyAppendage

(4,619 posts)
10. The brain is way more complex than a petri dish with gel.
Sun Oct 12, 2014, 09:11 PM
Oct 2014

While certainly interesting, the brain is WAY more complex with all sorts of supporting cells that have their own functions in response to beta amyloid aggregation.

Also, this finding does NOT explain the well known phenomenon of amyloid positive brains that have little to no tangle formation.

Again, a great start, but I'm getting really sick of facile proclamations by the likes of Doraiswamy, who had NOTHING to do with the research, pontificating about the work being the next big step to a cure.

jeff47

(26,549 posts)
11. Yes, but it's a lot easier to get a new one.
Sun Oct 12, 2014, 09:23 PM
Oct 2014

The point of these in vitro analogs is to try out new ideas and new drugs. Because growing a new one is really easy, instead of getting another real brain.

Will they all work? Of course not. But it lets them run down some theories much faster, and with less risk to people.

NoodleyAppendage

(4,619 posts)
24. You cannot have a workable model without all variables
Mon Oct 13, 2014, 11:21 AM
Oct 2014

At least the mouse models have the full compliment of supporting cell types. What does it mean when they develop something to target the neuronal death in isolation, particularly when it is likely that microglia may either work against the tested treatment. If they are going to Petri dish models, then they need to better approximate all actual brain substrates/cell types.

jeff47

(26,549 posts)
25. Sure you can. How do you think we developed every single drug?
Mon Oct 13, 2014, 11:47 AM
Oct 2014

They start in vitro. Then they move to analogs like rats, pigs and monkeys. Then they move to humans.

That in vitro model does not come remotely close to "all variables". But it tells you what won't even work in the simplest situation. And you can try a whole bunch of different stuff in a very short timeframe.

Then you move on to analogs. Adds a lot more variables. And a lot of stuff that worked in vitro doesn't work. But since it takes weeks to months in order to do a single test, you save a lot of time throwing out what didn't work in vitro. The ones that don't work go back to the drawing board with the new information. Things that worked go on to human trials.

In human trials, most new treatments fail. Those go back to the drawing board. A small number work better than the old treatment or placebo, and we end up with "an amazing new drug".

You appear to be coming at this as if in vitro success will immediately go to human trials. That is not the case. But in vitro literally lets you say "well, let's see if this does anything" with an enormous number of possible treatments.

tiptonic

(765 posts)
12. Fantastic
Sun Oct 12, 2014, 09:31 PM
Oct 2014

This is fantastic. Lets hope we can keep it out of the hands, of the religious anti-stem cell crowd.

 

Spitfire of ATJ

(32,723 posts)
19. Michelle Bachman will now claim scientists are breeding human brains in dishes....
Mon Oct 13, 2014, 03:29 AM
Oct 2014

And someone will do a commemorative plate about it.

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