Covid-19: Hopes Rise Over Experimental Drug REMDESIVIR, Trials Launched
'Hopes rise over experimental drug's effectiveness against coronavirus.' Many see remdesivir as one of few drugs that has reasonable prospect of helping patients. The Guardian, March 10, 2020.
A US biotech firm has ramped up production of an experimental drug that has become a focal point for hopes of an effective treatment for coronavirus. The first clinical trial of the antiviral medicine remdesivir in Covid-19 patients is due to report its findings next month according to Gilead Sciences, which said it had accelerated manufacturing of the drug to increase its supplies as rapidly as possible.
As the coronavirus outbreak has unfolded, about 300 separate trials into different drugs and experimental therapies have been launched in the absence of any established treatments. Many see remdesivir, originally developed to treat Ebola, as a frontrunner and one of the very few drugs that has a reasonable prospect of helping patients in the near-term. As a therapy, it could potentially help make peoples disease less severe, save lives for those hospitalised, and be used prophylactically for hospital workers and perhaps even in the community to limit spread out there, said Timothy Sheahan, a virologist who has studied the drug at the University of North Carolina, Chapel Hill. But he added that the wider use of the drug in the unfolding epidemic was completely contingent on its success or failure in the trials.
While awaiting these results, doctors in the US, China and Italy are already using remdesivir on a compassionate basis to treat small numbers of patients with severe Covid-19. The first US patient, a 35-year-old man in Snohomish County, Washington, recovered, but the full trials are needed to assess whether the drug reduces the severity of symptoms and, crucially, mortality rates. David Ho, a Columbia University professor and infectious disease specialist, agrees that remdesivir is the most promising candidate. In New York, we have one case in our hospital right now and were trying to access that drug for our critically ill patient, he said. The team were waiting to hear back from Gilead about whether the hospitals request for compassionate use had been approved. Doctors in the UK have been told there is a limited supply of remdesivir available on request.
The drug is being evaluated in multiple trials, the first two of which began recruiting patients in China in early February and another is enrolling patients in the US. Two further trials are due to launch this month in Asia and other countries with high numbers of Covid-19 patients which will compare two different doses of the drug and are expected to report as early as May. Gilead stressed that it was boosting production in anticipation of potential future needs before knowing whether the trial would show the drug to be safe and effective at treating patients with the virus.
Other compounds being tested include the anti-HIV drug Kaletra and other medicines that are normally used to treat hepatitis and malaria...
More, https://www.theguardian.com/world/2020/mar/10/hopes-rise-over-experimental-drugs-effectiveness-against-coronavirus
* Science News, 'Repurposed drugs may help scientists fight the new coronavirus,' Match 10, 2020.
https://www.sciencenews.org/article/coronavirus-covid19-repurposed-treatments-drugs
lagomorph777
(30,613 posts)appalachiablue
(41,127 posts)just Bezos will need to supply covid-19 tests, like Gates is doing in Washington state. Hopefully it won't come to that, but we're OUT OF TIME. The stalling is deadly BS.
https://www.theverge.com/2020/3/9/21171308/coronavirus-gates-foundation-home-testing-seattle-covid19-flu
lagomorph777
(30,613 posts)Blue states will undoubtedly perform better than red states. But it will be for nought if the whole country doesn't deal with it properly.