Aspirin Trialled As Potential Treatment For Aggressive Breast Cancer

[appalachiablue]

- The Guardian, Aug. 18, 2021. Hopes raised that drug could work well with immunotherapy for triple-negative breast cancer patients.

Aspirin is being trialled as part of a potential treatment for an aggressive form of breast cancer. Researchers hope the cheap and widely available drug could work well when combined with immunotherapy for patients with triple-negative breast cancer. The trial, funded by the Breast Cancer Now Catalyst Programme, which aims to speed up progress in research through innovation and collaboration, is the first clinical study to test if aspirin can make tumours more sensitive to immunotherapy in these patients.

The research, led by Dr Anne Armstrong from the Christie NHS foundation trust in Manchester, will trial the drug avelumab both with and without aspirin before patients receive surgery and chemotherapy treatment. Breast Cancer Now said successful results could lead to further clinical trials of aspirin and avelumab for incurable secondary triple-negative breast cancer which happens when cancer cells that started in the breast spread to other parts of the body.

There are about 8,000 women diagnosed with triple-negative breast cancer in the UK each year, the charity said. It is a less common but often more aggressive type of breast cancer that disproportionately affects younger women and black women, the organisation added. Armstrong, a consultant medical oncologist and honorary senior lecturer, said: “Our earlier research has suggested that aspirin can make certain types of immunotherapy more effective by preventing the cancer from making substances that weaken the immune response.

“Anti-inflammatory drugs like aspirin could hold the key to increasing the effectiveness of immunotherapy when used at the same time. Trialling the use of a drug like aspirin is exciting because it is so widely available and inexpensive to produce. We hope our trial will show that, when combined with immunotherapy, aspirin can enhance its effects and may ultimately provide a safe new way to treat breast cancer.”...

Read More,
https://www.theguardian.com/science/2021/aug/18/aspirin-trialled-as-potential-treatment-for-aggressive-breast-cancer
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Also: 'Aspirin may help treat aggressive breast cancer,' BBC, Aug. 17, 2021,
https://www.bbc.com/news/health-58229082

[marble falls]

1. I love it when they go to an "old dog" and discover he knows "new tricks"!

[appalachiablue]

3. You know it, Old is Gold. My grandfather, a dentist

followed it. Mom always applied the aspirin, and salt treatment.

[Diamond_Dog]

2. Very encouraging news!

[appalachiablue]

4. Indeed it is, DD!