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Related: Culture Forums, Support ForumsPSA: O Negative is universal donor; AB Positive is universal recipient
O Positive can be given to men or to women past child-bearing age, but usually is done only in a dire emergency and with physician or Pathologist approval.
I saw the blood type thread at work this afternoon (slow day); I felt this was important enough to give it a thread so it wouldn't get lost in the shuffle. Ymmv.
I'm a medical lab technician, so do routine blood typing, antibody screens and cross-matches as part of my job.
For anybody who cares, here is a summary of what the typing stands for.
Red blood cells have a variety of proteins in their membranes called antigens. Because they are part of our body's system, we normally don't develop antibodies to the antigens we have and only develop antibodies when exposed to foreign antigen, usually but not always through transfusion. (A reminder: antibodies are part of the immune system, and function to flag and rid the body of "not self/foreign" invaders. Blood antibodies float around in the plasma.)
ABO System
However, A and B are antigens that are apparently similar to to something in nature, possibly a bacteria, that cause us to develop antibodies to A or B shortly after we're born if we don't have them on our cell membrane, that is if they are "not self."
People who are Type A have only A antigen and shortly after birth will develop anti-B antibodies through environmental exposure. If you give them Type B red cells, their anti-B antibodies will bond with the transfused Type B blood cells and cause a severe, likely fatal, transfusion reaction.
People who are Type B have only B antigen and shortly after birth develop anti-A antibodies through environmental exposure. If you give them Type A red cells, their anti-A antibodies will bond with the transfused Type A red cells, and cause a severe, likely fatal, transfusion reaction.
People who are Type O lack both A and B antigen, and shortly after birth develop both anti-A and Anti-B antibodies. If they are transfused with A, B or AB, they will have a severe, likely fatal, transfusion reaction. However, because they lack A and B antigen, then can be transfused into A, B or AB because they don't have anything for the patient's anti-A and anti-B antibodies to bond with.
People who are Type AB have both A and B antigen, and do not develop A or B antibodies. Therefore, you can give them A, B or AB and they won't have a reaction. However, you can't give them to anybody else because they bond with their anti-A and anti-B antibodies.
Positive versus Negative
People who are (Rh) Positive have D antigen and don't develop D-antibodies. People who are (Rh) Negative (for D) lack D antigen and may develop anti-D antibodies if exposed through transfusion or through pregnancy.
Antibody screen
There are other less common antigen families on our red cells to which we can develop antibodies if we're transfused or sometimes through certain illnesses. The antibody screen tests for the most common ones. Patients that test positive to the screen are further tested to identify the antigen(s) and if they need to be transfused, we order special blood proven to be free of that antigen from the American Red Cross.
Oh, and going back to the other thread, I am an extremely rare subtype of A Negative, so my blood isn't real useful for donation, and as a recipient I would require O Neg. That's a whole 'nother level of detail on the above.
hobbit709
(41,694 posts)FreeState
(10,570 posts)phylny
(8,379 posts)I remember I found out when we did some sample blood typing in 9th grade biology. My biology teacher was very excited when I came up AB+
CaliforniaPeggy
(149,588 posts)It's full of excellent facts that we all should be exposed to.
I'm bookmarking it in case I run across any other threads where this info would be useful.
pinboy3niner
(53,339 posts)I was told long ago that I had developed a very rare antigen from multiple transfusions, and that I could be transfused only with blood that is negative for that antigen. They even gave me a card identifying the antigen, which was a long string of letters and symbols. I was told only that the antigen is extremely rare, and that it was being studied by the W.H.O. at the time (late '70s).
It's nice to finally have a clue about what it all means, lol. Thanks for the clear explanation.
magical thyme
(14,881 posts)even with a carrying card.
Every patient is treated as a new patient when it comes to type, screen, antibody identification and crossmatch. We don't even trust co-worker's testing because the consequences of an error can be fatal.
(btw, just to clarify, you developed an antibody to the foreign antigen. )
pinboy3niner
(53,339 posts)I lost the card years ago.
And yes, I meant I received the antigen and developed the antibody.
Thanks, again.
magical thyme
(14,881 posts)The antibody numbers can decline over time, to undetectable or barely detectable levels, so a screen could miss it, especially the older tube screening test which is more prone to tech error. Also, many people don't produce antibodies, so it's important to know that you do produce them.
PassingFair
(22,434 posts)Does this mean that my blood is less desirable, donation-wise?
I hope so, because the one time I tried to donate blood, I flat-out fainted when I tried to get up.
Paulie
(8,462 posts)magical thyme
(14,881 posts)But you can get blood from anybody.
Skittles
(153,150 posts)you can NEVER be given the wrong blood type - you can have 'em all!!! The O neggers, who can GIVE to everyone, can only receive O neg except for certain circumstances
you are right that your blood is not coveted, but your platelets certainly are - if you ever want to give, try donating platelets
In_The_Wind
(72,300 posts)FreeState
(10,570 posts)Im also AB+. I haven't given since then and can't anyways as gay men are banned from donating (still). Id gladly try again if I were allowed though.
840high
(17,196 posts)Skittles
(153,150 posts)I'm a 45 gallon platelet donor
libodem
(19,288 posts)Like nobody's business!
rurallib
(62,406 posts)I have often thought that blood donors who rack up those kind of numbers (say over 25 gallons) deserve some major public recognition.
We thank you.
I join you as a platelet / white cell donor.
Skittles
(153,150 posts)I really don't do anything but lay there and watch a movie; easiest way I can think to "give back" to the community (that and donate to the local food bank) I don't find what I do amazing in any way; what I find so amazing is how few people donate to the blood bank yet always expect the product to be available for them and their loved ones
rurallib
(62,406 posts)to do it all those years.
littlemissmartypants
(22,632 posts)In_The_Wind
(72,300 posts)loudsue
(14,087 posts)Response to loudsue (Reply #19)
A HERETIC I AM This message was self-deleted by its author.
Foolacious
(497 posts)It's a form of O positive, but the D antigen is so weak that it barely registers. As a donor, I'm considered O positive, but as a recipient, I'm considered O negative. Different blood typing agencies have had different policies about that over the years. At one time I had a blood type card in New York state classifying me as O negative while I still had one from California classifying me as O positive, and these weren't oversights -- these were correct according to the standards (at that time) of the two different agencies.
magical thyme
(14,881 posts)would list you as D positive as a donor.
We err on the side of caution. Rh neg blood doesn't have any D antigen so if receive Rh neg blood and you have any D antibodies, you're safe.
If your red cells are donated to somebody who is Rh neg, they could stimulate their immune system to form anti-D antibodies.
Weak D reaction is due to one of 3 causes. Genetically it may be due to reduced production of antigen due to a weakened D from one parent and no D from the other. It may be due to locus; the gene is part of a haplotype made up of CDE. If the D antigen is directly across from C, the C hides the antigen site. And it can be "Partial D" where pieces of the D are prone to breaking off, so don't react or don't form strong reaction bonds.
rurallib
(62,406 posts)started just out of high school.
The hospital lost records so we don't know how much i have given.
Been doing platelets and white cells for @ 20 years.
Just gave my 6th donation of the year Monday.
loudsue
(14,087 posts)We need a smilie for that!