Grape seed extract kills head and neck cancer cells, leaves healthy cells unharmed

[OKIsItJustMe]

http://www.coloradocancerblogs.org/news/grape-seed-extract-kills-head-and-neck-cancer-cells-leaves-healthy-cells-unharmed

[font face=Times, Serif][font size=5]Grape seed extract kills head and neck cancer cells, leaves healthy cells unharmed[/font]

January 26, 2012 By Garth Sundem

[font size=3]Nearly 12,000 people will die of head and neck cancer in the United States this year and worldwide cases will exceed half a million.

A study published this week in the journal Carcinogenesis shows that in both cell lines and mouse models, grape seed extract (GSE) kills head and neck squamous cell carcinoma cells, while leaving healthy cells unharmed.

“It’s a rather dramatic effect,” says Rajesh Agarwal, PhD, investigator at the University of Colorado Cancer Center and professor at the Skaggs School of Pharmaceutical Sciences.

…

Grape seed extract creates these conditions that are unfavorable to growth. Specifically, the paper shows that grape seed extract both damages cancer cells’ DNA (via increased reactive oxygen species) and stops the pathways that allow repair (as seen by decreased levels of the DNA repair molecules Brca1 and Rad51 and DNA repair foci).

…[/font][/font]

http://dx.doi.org/10.1093/carcin/bgs019

[dixiegrrrrl]

1. Wonder if buying grapes will be banned

so Big Pharma can make a killing on patenting grape seeds .

google "grape seed extract" to find the many uses for the stuff, going back decades.

[Celebration]

3. Don't be silly

We could buy our fill of seedless grapes!

[valerief]

9. They'd have to ban wine, too. nt

[Celebration]

2. K and R! n/t

[Mnemosyne]

4. Now we understand why alternative meds are being demonized so much. n/t

[sinkingfeeling]

5. As a 3 year survivor of squamous cell carcinoma of the tonsils, thanks

for posting this. I just sent it on to the leader of my SPOHNC group.

[OKIsItJustMe]

7. You’re most welcome!

I hope this pans out.

[dixiegrrrrl]

10. My mother died of squamous cell carcinoma

back in the early 1980s.....
I am very happy that alternative healing is being looked into.

[tabatha]

6. Thank you. The skeptics have said that it is unscientific and that just pharmaceuticals cure.

Grape seed extracts are industrial derivatives from whole grape seeds that have a great concentration of vitamin E, flavonoids, linoleic acid, and OPCs. The typical commercial opportunity of extracting grape seed constituents has been for chemicals known as polyphenols, including oligomeric proanthocyanidins recognized as antioxidants.

1 Potential anti-disease effects
2 Research
3 Dosage, precautions and interactions
4 Aromatase Inhibitor
5 References
6 External links
[edit]Potential anti-disease effects

Human case reports and results from laboratory and animal studies provide preliminary evidence that grape seed extract may affect heart diseases such as high blood pressure and high cholesterol.[1] By limiting lipid oxidation, phenolics in grape seeds may reduce risk of heart disease, such as by inhibiting platelet aggregation and reducing inflammation.[2] While such studies are promising, more research including long-term studies in humans is needed to confirm initial findings.

http://en.wikipedia.org/wiki/Grape_seed_extract

[OKIsItJustMe]

8. Let’s not forget alzheimer’s

http://nccam.nih.gov/research/results/spotlight/062408.htm
http://www.mssm.edu/about-us/news-and-events/a-natural-chemical-found-in-grape-seeds-may-prevent-development-or-progression-of-alzheimers