Health
Related: About this forumDid This 15-Year-Old Kid Just Change the Course of Medicine?
LinkWhats so revolutionary about Andraka's epiphany, aside from possibly being the most inexpensive medical test ever devised, is that current methods for pancreatic cancer detection are woefully ineffectivefor the most part, they're unable to uncover the presence of the disease until its in its final stages, long after it could respond to treatment. That's why the American Cancer Society reports that on average, the one-year survival rate for a patient is just 20 percent, and the five-year rate is a dismal four percent.
...........snip.......................
But this is about more than pancreatic cancer. Andraka explains his strips can be altered to detect biomarkers for other conditions as well. Whats so cool about that is its applicability to other diseases for example other forms of cancer, tuberculosis, HIV, environmental contaminants like E Coli, salmonella, he says. All for three cents for a test that takes five minutes to run.
He has big plans to turn the medical community on its ear by mass marketing his work, making it widely available. He says, Essentially what Im envisioning here is that this could be on your shelf at your Walgreens, your Kmart. Lets say you suspect you have a condition you buy the test for that. And you can see immediately if you have it. Instead of your doctor being the doctor, youre the doctor. The teenager reports that hes already in talks with major corporations like LabCorp and QuestDiagnostics to bring his kits to store shelves as soon as possible, though how long that may actually take isnt yet known.
Scuba
(53,475 posts)"What motivates me is that 100 people die every day from pancreatic cancer. And so when I'm working I think those 100 people are who I'm working for today."
Jack Andraka created a simple dip-stick sensor to test for levels of mesothelin, which is a biomarker for early-stage pancreatic cancer thats found in blood and urine. The method is similar to diabetic testing strips, utilizing just a pinprick of blood and costing all of three cents to make.
Bravo Jack!
sinkingfeeling
(51,445 posts)Old Codger
(4,205 posts)This is a BFD
Xipe Totec
(43,890 posts)Sugarcoated
(7,722 posts)I hope it can be made to detect ovarian cancer early.
ColumbusLib
(158 posts)My Mom could still be alive today...
tclambert
(11,085 posts)So why would you take the test? You would have to add it and all the others to the tests done during a routine physical. Okay, it's cheap enough to do that. Please proceed.
ajk2821
(89 posts)My family recently has had several types of cancer aggressively appear where none did before. I and my brothers have all gone through every test we can think of to establish a baseline for ourselves. This sounds a lot less intrusive than the colonoscopy I did.
AllyCat
(16,177 posts)Men, historically, are the least likely to go to the doctor for many reasons. So here, a partner could encourage inexpensive testing from the local drug store. No one misses work. Early detection. Early piece of mind.
You don't have to be sick to have a disease process going on. Would probably need an ad campaign/PSA or something, but many lives could be saved if they tested themselves once a year at home.
Dawgs
(14,755 posts)You know why people would take the test, even without symptoms. Don't be so deliberate, okay.
Duppers
(28,120 posts)Why wouldn't most adults ck themselves, say every couple of years?
DeSwiss
(27,137 posts)Besides, the cancers he's developing these strips to identify are all best treated successfully when caught early. Not too late to matter.
- And, three cents. It was in the article.
Warpy
(111,245 posts)and at the usual medical markup. They might cost three cents apiece to manufacture, but not when you add in the costs of rigid QC, marketing, shipping, and the rest of it.
Likely laboratories will buy these strips by the thousand and use them for routine bloodwork for everyone as part of general screening during physicals. I don't see this stuff being available at Walgreen's unless it's marketed as part of a multi strip package that detects a whole range of diseases.
DeSwiss
(27,137 posts)...etc. Nor anything else related to the existing perverted system of medical care delivery. The poster's statement I was responding to was:
''For it to work with pancreatic cancer, you have to take the test when you show no symptoms.''
So it was my point that no matter how it's delivered, what other expenses and/or ''costs'' are tacked onto it -- three cents is still three cents. And at that price, with or without the additional expenses, almost anyone can afford to buy a disease test strip or to get a cheap costing test from the medical institution du jour.
Which is a much, much better plan than waiting until the cancer is a certainty using the current testing methods, which are almost always too late to treat effectively -- as the article stated.
brush
(53,764 posts)calimary
(81,220 posts)Flying Squirrel
(3,041 posts)I hope his parents were smart enough to get a patent lawyer right off the bat.
AllyCat
(16,177 posts)They make it for 3 cents or heck, even 2.5 cents and sell it for $900 by prescription only so you can do your part to fuel their profits and the Medical Industrial Complex.
I hope this kid gets all the credit.
Moostache
(9,895 posts)And yet we still cannot get a public option for insurance.
The basic research that should be done in medical testing and in sciences in general is a benefit to all of society, but the way it happens now is brilliant people have an insight and make a contribution only to see it immediately snapped up and patented and the profits go to a CEO who "works" 5 hours a month and hob-nobs the rest of the time.
As in all aspects of our doomed "civilization", we can find endless piles of money for invasions, war, killing and weapons...but when its time for spending money on something like basic medical research or even more fundamental science research, suddenly the cries of poverty and government intrusion are deafening. Same in any industry - energy, food, insurance, you name it.
Maybe I will be lucky enough to live to see the political visionaries that lead us out of these pseudo Dark Ages...I had hoped it would be Obama, and he has at least taken the foot off the accelerator to doom, but sadly the car is not turning and that hair-pin turn in the road is coming up alarmingly fast...
Dustlawyer
(10,495 posts)MicaelS
(8,747 posts)With open arms. They will be thinking of all the money they can save by early detection and treatment, instead of having to pay for transplants.
justabob
(3,069 posts)this kid needs to keep this discovery his own if at all possible. If big medico/pharma gets a hold of it, a 3 dollar test will cost 3000 before the ink is even dry.
loudsue
(14,087 posts)They make too much money keeping everyone sick.
dixiegrrrrl
(60,010 posts)So I am hoping he can find a reputable business for his product.
WASHINGTON, March 23, 2012 /PRNewswire-USNewswire/ -- Quest Diagnostics Incorporated (Quest) and Laboratory Corporation of America (LabCorp), the nation's two largest laboratories, are currently involved in a multi-billion dollar Medicare scam, according to a lengthy and critical expose published in one of the medical laboratory industry's leading trade publications.
The scam works like this: Quest and LabCorp provide kickbacks to private insurance companies in the form of deeply-discounted and sometimes below-cost lab fees. In exchange, the insurance companies pressure doctors in their networks to send all of their patients' lab work, including Medicare and Medicaid patients, to either Quest or LabCorp. The labs fund the kickbacks (lower lab fees for private insurance patients) by overcharging Medicare and Medicaid patients anywhere from 70% to 500% higher. For example, Quest charged the State of California $8.59 for a complete blood test, but billed private insurers only $1.43.
http://www.prnewswire.com/news-releases/medicare-scam-by-quest--labcorp-exposed-says-npt-associates-143970756.html
Moostache
(9,895 posts)a kennedy
(29,647 posts)OMGosh, love him and his epiphany!!!
snort
(2,334 posts)Like the pharmaceuticals hadn't thought of this yet. If people aren't sick and dieing then there goes the profit! They don't want prevention, they want sick people who won't argue about the price of a pill.
chervilant
(8,267 posts)they never talk about plant based diets.
I have been a Vegan for almost a year now, specifically because of health concerns and no insurance. I cannot quantify how much better I feel. AND, I have lost weight -- two sizes, at least.
The AMA and Big Pharma (and Agri-business?) would rather we continue to over-consume animal products and processed foods. They make a pill to regulate cholesterol rather than tell you how to eat healthy and exercise.
snort
(2,334 posts)I've been off the meat for about 5 years now and most definitely feel better for it all the way around. I lost some weight as well!
chervilant
(8,267 posts)that so many of my friends and family are quick to denigrate my decision. They routinely try to feed me animal products.
I made some Vegan granola yesterday, for a quick breakfast, and it's yummy, but quite filling. All my ingredients are organic.
I am also walking these hills and hope to resume power walking four miles a day.
snort
(2,334 posts)I've had family members react as if I had started doing something abnormal or UN-American.
Ditto on the exercise as well. Lucky me, I get to take my hikes in the Grand Canyon and around the base of the Vermillion Cliffs. It is simply stunning and though I get tired I never tire of it.
If you ever get a chance, I would highly recommend it.
Bay Boy
(1,689 posts)...I wonder how many people would purchase this. The ones I can think of are people with family histories of pancreatic cancer and I suppose that by itself is enough reason. I just don't see a spur of the moment "Hey I always wondered if I had pancreatic cancer" purchase.
NYC_SKP
(68,644 posts)Fuckers.
Dustlawyer
(10,495 posts)the first 4 days, then 1 every 2 months for life. I would not suffer from the severe, constant pain i have in my arms, hands, legs and feet once on the treatment. Did i mention that they cost $15,000 per treatment!
2on2u
(1,843 posts)Dustlawyer
(10,495 posts)2on2u
(1,843 posts)you like.
http://www.amazon.com/Alpha-Lipoic-Acid-Breakthrough-Antioxidant/dp/0761514570/ref=sr_1_1?ie=UTF8&qid=1359596426&sr=8-1&keywords=the+lipoic+acid+breakthrough
5.0 out of 5 stars Encouraging for Diabetics February 26, 2000
By A Customer
Format aperback
I began taking a-lipoic acid and achieving great results before this book was published. It was encouraging to finally read a book that validated my experience with lipoic acid. This book explains a-lipoic acid in layman's terms and sheds light on the value of this nutrient. As a Type I diabetic of 36 years, I have essentially reversed diabetic neuropathy by taking 900 mg of a-lipoic acid per day. I highly encourage diabetics to research a-lipoic acid especially if suffering from neuropathy. This book is a great start.
ChazInAz
(2,564 posts)If this had been around in 2009, we could have licked the C-dif that killed my wife before it got so thoroughly established.
More power to the inventor!
loudsue
(14,087 posts)I hope other families can some day avoid a loss like that.
joanbarnes
(1,722 posts)grahamhgreen
(15,741 posts)So I imagine your right
Smilo
(1,944 posts)you are going to save a lot of lives with these strips.
Your family must be so proud of you. Here on DU - we are cheering you on - here's to much more success in the future.
FailureToCommunicate
(14,012 posts)test works, and becomes widely - and inexpensively- available... kudos forever to this kid!
grahamhgreen
(15,741 posts)We even started a company to sell these over the counter in Thailand in 1999, but were rebuffed by the medical industry.
Currently, you don't even need blood, they work on saliva.
They should be in every 7-11 next to the condoms - why aren't they?
loudsue
(14,087 posts)and the judges and legislatures keep protecting corporate profits over the welfare of the people.
progressoid
(49,978 posts)I saw it advertised on the television machine a couple days ago.
grahamhgreen
(15,741 posts)I think they make them for less than $1
But, at least you can test at home. However the price point needs to be $5, IMHO
annabanana
(52,791 posts)Are NOT his friends.. or OURS.
I would sooner throw the research out the window than let the like of them patent it, raise the price so only the 1% can afford it, and keep it away form us for the next 50 years.
SunSeeker
(51,550 posts)DallasNE
(7,402 posts)The degree to which this is a breakthrough. My hope is that it will be 100%. Since the concept is not new I have to wonder why others have not moved in this direction a long time ago, making me a skeptic.
skepticscott
(13,029 posts)No test is 100% accurate. They all have false positive and false negative rates, especially when self-administered, as people seem to be envisioning this one.
And yes, I doubt this kid discovered that this was a marker for PC all by himself, and the idea of dip test strips is old. At the very least, there's more to be told than in the linked article,
ReRe
(10,597 posts)....reminds me of recently departed Aaron Swartz. Both young, both giving life to their wildest brilliant imaginings, desiring to bring social change for good on a global scale.
eppur_se_muova
(36,259 posts)I guess they have a low opinion of their readers' intelligence, or at least their curiousity.
skepticscott
(13,029 posts)a lot of things they like to hear, among them that someone working alone has discovered something that all those "know-it-all" scientists couldn't, and that a "little guy" is going to undercut Big Pharma (or Big Oil, or Big Media, or whatever). It also lets their paranoia and conspiracy-mongering get a running start.
Celebration
(15,812 posts)Use Google???
http://www.smithsonianmag.com/science-nature/Jack-Andraka-the-Teen-Prodigy-of-Pancreatic-Cancer-179996151.html?c=y&page=2
Andraka wrote up an experimental protocol and e-mailed it to 200 researchers. Only Maitra responded. It was a very unusual e-mail, he remembers. I often dont get e-mails like this from postdoctoral fellows, let alone high-school freshmen. He decided to invite Andraka to his lab. To oversee the project, he appointed a gentle postdoctoral chemist, who took the baby-sitting assignment in stride. They expected to see Andraka for perhaps a few weeks over the summer.
donco
(1,548 posts)is his thought process. ("What motivates me is that 100 people die every day from pancreatic cancer. And so when I'm working I think those 100 people are who I'm working for today." )
BRAVO!! Hope that he keeps that.
BlueStreak
(8,377 posts)I read the article twice and I don't see where it says he actually has done anything more than propose the concept. Has he actually created a test strip that has proven to be effective in early diagnosis of pancreatic cancer? If so, that is huge, but I don't see where the article says that.
I want to believe there is something here, but I am not seeing it. Can somebody please show me where this isn't just some kid talking about a fantasy.
And if he has come up with such a test, it is really mind-boggling that all the pharmaceutical companies in the world somehow missed something like this, considering that they all employ a bunch of really smart scientists and all of them instinctively understand the value of early detection.
Celebration
(15,812 posts)also
About 2:30 a.m. one December Sunday, Jane Andraka was jolted from her parking lot stupor by an ecstatic Jack. He opens the door, she remembers, and you know how your kid has this giant smile, and that shine in their eye when something went right? The test had detected mesothelin in artificial samples. A few weeks later, it pinpointed mesothelin in the blood of mice bearing human pancreatic tumors.
Read more: http://www.smithsonianmag.com/science-nature/Jack-Andraka-the-Teen-Prodigy-of-Pancreatic-Cancer-179996151.html#ixzz2JP3bOcPK
Follow us: @SmithsonianMag on Twitter
BlueStreak
(8,377 posts)Note this quote:
when his biology teacher confiscated his clandestine reading material on carbon nanotubes, he was in the midst of the epiphany that scientists think has the potential to save lives.
Pardon me. If this thing can detect pancreatic cancer so easily, there would have been hundreds of researchers all over this running tests on patients already diagnosed with the disease, and it seems like we would have heard of at least one case where the test was able to do early detection.
Why is there no mention of the accuracy his invention has shown so far?
And excuse me if I am skeptical that a person can build a particle accelerator in his basement.
Maybe I'm suffering from Manti Te'o overload, but this smells like BS to me. I honestly hope it is not, but I see all sorts of red flags here.
Celebration
(15,812 posts)And, then, get manufactured, have quality control, etc. Not sure why you think it is suspicious.
BlueStreak
(8,377 posts)looks like a kid who said, basically, "I will cure cancer by combining nanotubes with electricity making a test strip that will only cost a few cents."
Look, the kid might be bright. Or he might have a father who is promoting him for sensational purposes. Conspicuously missing from the article were:
1) Any details about the solution
2) Any indication that it is more than just some daydream -- No evidence that even a prototype has been assembled in some crude form and tested successfully
3) Any respected scientist saying something like "Wow, the rest of us are such a bunch of fools. We have been spending billions every year for this and the kid just showed us exactly how we can detect Pancreatic cancer much earlier. Now that we see the solution, we can see it looks like a genuine breakthrough."
Lacking any of those things, it sounds to me like a hype job.
Regarding the Intel award, I don't know anything about that award, but there are lots of science awards given to students based mostly on their attitude and enthusiasm, rather than the demonstration of some fundamental scientific breakthrough. If we required a genuine scientific breakthrough before giving any science awards to high schoolers, there wouldn't be many awards given.
I hope I am completely wrong, but I think not. There are far more charlatans than geniuses.
Celebration
(15,812 posts)Are you familiar with the contest?
http://www.intel.com/content/www/us/en/education/competitions/international-science-and-engineering-fair/winners.html
He is getting the publicity because he is the grand prize winner. They always get publicity. Major publicity.
You can't blame him for whatever the various articles leave out. He is the friggin' INTEL GRAND PRIZE WINNER.
Does that mean nothing to you? A promoting father??? More like an encouraging father.
BlueStreak
(8,377 posts)If not, then it is a daydream, a "hey, wouldn't it be cool if ..." thing.
If so, why didn't any of the hundreds of articles mention that "minor detail"?
Celebration
(15,812 posts)You can use Google to find it.
BlueStreak
(8,377 posts)has actually been used to identify that marker reliably. The articles I read didn't even say it was LIKELY to improve on our ability to identify the market. It just said, essentially "wouldn't it be cool if we used some nanotubes and knitting needles and a battery to cure cancer."
But no point arguing about this. I need to go install the new magnets that just arrived. They will improve my gas mileage by 30%.
Celebration
(15,812 posts)Like high school kids have the money for placebo controlled double blind studies, filtered through the FDA.
Why in the heck do you think he had to involve Quest?
BlueStreak
(8,377 posts)Is there some reason he would have trouble obtaining a blood sample of a patient already diagnosed with pancreatic cancer?
It seems to me that there must be some expert in the field who: a) would have been all over that, and b) would be willing to stand up and say that the idea has real merit. I don't even see that in any of the articles. Just "I bet if we use nanotubes and some electricity we'll cure cancer."
As others have pointed out, this has now been out there 6 months. If it were really as described, there would be all sorts of news about this by now. Because, as it turns out, there actually is a lot of interest in finding real cures for cancer.
Celebration
(15,812 posts)Have you heard of Wikipedia?
If you are interested in a subject, and want more answers to your questions, has it occurred to you to use them?
http://en.wikipedia.org/wiki/Jack_Andraka
The antibodies would bind to the mesothelin and enlarge. These beefed-up molecules would spread the nanotubes farther apart, changing the electrical properties of the network: The more mesothelin present, the more antibodies would bind and grow big, and the weaker the electrical signal would become.[8]
A dose-response curve was constructed with an R2 value of 99.92%. Tests on human blood serum obtained from both healthy people and patients with chronic pancreatitis, pancreatic intraepithelial neoplasia (a precursor to pancreatic carcinoma), or pancreatic cancer showed a similar response. The sensors limit of detection sensitivity was found to be 0.156 ng/mL; 10 ng/mL is considered the level of overexpression of mesothelin consistent with pancreatic cancer. Andraka's sensor costs $3.00 and 10 tests can be performed per strip, taking 5 minutes each. The method is 168 times faster, 26,667 times less expensive, and 400 times more sensitive than ELISA, and 25% to 50% more accurate than the CA10-9 test.[6]
Officials at Intel have said that Andraka's method is more than 90 percent accurate in detecting the presence of mesothelin.[1]
BlueStreak
(8,377 posts)Seems like extraordinarily shoddy reporting. They should have included at least a summary of those results. It isn't overly complicated.
riverbendviewgal
(4,252 posts)He refused to patent his polio vaccine.
This kid reminds me of him
valerief
(53,235 posts)Big Money doesn't like competition.
elias7
(3,997 posts)May be useful, may not be, like other tumor markers like afp, CA-125, PSA, etc. Needs some study... It's not a miracle.
mchill
(1,018 posts)I was in the hospital being treated for breast cancer and having a prophylactic salpingo-oopherectomy (to prevent ovarian cancer) as I have the brca2 gene. This gene also makes me 7x more susceptible to pancreatic cancer and melanoma than people not carrying this gene. I thought, ok, almost have 3 of these 4 cancers licked (almost), but there's nothing that can be done to detect pancreatic cancer early. Ruth Bader Ginsberg has survived a few years after her pancreatic cancer was diagnosed with a "routine CT exam." No one gets a routine CT exam, but that's what it would take.
I was grateful to hear of his discovery. I told my surgeon (from my hospital bed) about the discovery. She is a brca researcher. She was pleasantly surprised and after I described to her the story that I heard about the teststrips, she said to me "they've been trying to get a test like this for a long time with no success." She looked amazed and I can still hear say "Really?"
As I recall, this young man won a $50,000 prize from Google and was also a National Junior Kayak champion. Sounds like he will be a success no matter he does.
WinstonSmith4740
(3,056 posts)The fact that a 15 year old (figure a sophomore) even knows the word "epiphany" AND used it correctly is amazing in itself. This kid must be awesome. I sure hope he has this thing protected...I can see Big Pharma getting hold of this and jacking up the price to obscene heights.
Thor_MN
(11,843 posts)Being able to diagnose oneself with an expensive to treat disease without the insurance industry knowing will not sit well with them.
Sherman A1
(38,958 posts)tomp
(9,512 posts)bad idea. surely this may give people a head start on combatting an illness. and surely in the age of the internet people can become very well educated about health/illness. but to think "you're the doctor" is a very dangerous idea for one's own health, and demeaning to highly trained professionals.
deutsey
(20,166 posts)Orrex
(63,203 posts)Hell, when I was 15, the best I could manage was a handful of tortured and half-assed sonnets to a girl who barely knew my name, and then this kid comes along and potentially revolutionizes diagnostic medicine?
Who the hell does he think he is?
Carepilot
(1 post)Innocence can be such a beautiful thing. Jack will go on to make even bigger waves as he grows up. We're sure of it.
Response to Celebration (Original post)
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