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Researchers find way to make unlimited amounts of red blood cells from iPS cells
Researchers find way to make unlimited amounts of red blood cells from iPS cells
December 06, 2013
THE ASAHI SHIMBUN
Japanese scientists have developed a technique using induced pluripotent stem (iPS) cells to engineer red blood cells in sufficient amounts to make shortages of blood for transfusions a thing of the past.
Researchers from Kyoto University’s Center for iPS Cell Research and Application (CiRA) and other institutions transduced c-MYC and BCL-XL genes, which are involved in cell proliferation and help prevent cell death or apoptosis, respectively, into iPS cells. The iPS cells then turned into erythrocyte progenitor cells.
The team led by Koji Eto, a stem cell biology professor at CiRA, was able to inhibit specific functions in the two genes, which turned the progenitor cells into mature erythrocytes--or red blood cells.
The erythrocyte progenitor cells have an almost unlimited ability to replicate in vitro, allowing researchers to produce almost infinite red blood cells from limited amounts of blood samples.
According to the researchers, the new technology produces 20 times the ...
December 06, 2013
THE ASAHI SHIMBUN
Japanese scientists have developed a technique using induced pluripotent stem (iPS) cells to engineer red blood cells in sufficient amounts to make shortages of blood for transfusions a thing of the past.
Researchers from Kyoto University’s Center for iPS Cell Research and Application (CiRA) and other institutions transduced c-MYC and BCL-XL genes, which are involved in cell proliferation and help prevent cell death or apoptosis, respectively, into iPS cells. The iPS cells then turned into erythrocyte progenitor cells.
The team led by Koji Eto, a stem cell biology professor at CiRA, was able to inhibit specific functions in the two genes, which turned the progenitor cells into mature erythrocytes--or red blood cells.
The erythrocyte progenitor cells have an almost unlimited ability to replicate in vitro, allowing researchers to produce almost infinite red blood cells from limited amounts of blood samples.
According to the researchers, the new technology produces 20 times the ...
http://ajw.asahi.com/article/behind_news/social_affairs/AJ201312060070
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