Scientists Reverse Memory Loss Caused by Aging in Mice

[William Seger]

https://interestingengineering.com/scientists-reverse-memory-loss-caused-by-aging-in-mice

Scientists at the University of Cambridge have found the cause of aging-related memory loss in mice. During the course of their research, they discovered that memory loss could even be reversed in old mice in laboratory experiments.

Scientists have been looking for the causes of age-induced memory loss. They found one in the scaffolding that holds the brain's neurons in place. Called perineuronal nets (PNNs), these cartilage-like structures surround the neurons in our brain. Intriguingly, these nets appear at the age of five in humans after a period of neuroplasticity during which the brain learns, adapts, and makes memories.

The role of the PNNs is to reduce the plasticity in the brain, making it less capable of creating new memories while increasing the efficiency of the brain in performing regular tasks.

This is why learning becomes difficult as we age — PNNs are working to make the brain more and more efficient. This is done by a PNN constituent called chondroitin 4-sulfate.

[unblock]

1. This is perfect because I happen to be working on a machine to turn men into mice

[Hortensis]

2. Memory loss, and potentially also crippling balance impairment. How soon

can I get a prescription? Me and a few billion others who have a lot of years to live well.

[William Seger]

4. You might be able to get one soon

... An orally taken drug that has been licensed for human uses for other conditions can perform this task. Researchers have used it in mice studies before and now believe it could also reverse aging-related memory loss. The team is currently working to see if the treatment can work for Alzheimer's disease as well.

I'm not sure what it takes to get an existing drug approved for additional uses, but I should think it's easier than getting a new drug approved.

[Hortensis]

5. Thanks! I'd think so too. That we're in a whole new era

of great medical advances is exciting and inspiring, but even more when realizing new futures of relative wellbeing could be opening up for aged people.

[Sneederbunk]

3. Good news for those who employ competent older mice.

[Ron Obvious]

6. I know what you're thinking, you dirty rat!

Did that mouse have two pieces of cheese or three?
Truth is I can't remember myself.

[BlueWavePsych]

7. LOL