Source:
Cleveland Plain DealerFebruary 04, 2008 00:01AM
At a major AIDS conference in Boston today, scientific players that include Case Western Reserve University will describe their dogged and ultimately successful attempt to reinvent an anti-HIV molecule known as PSC-Rantes that though potent, was also incredibly expensive to produce.
"We always felt we had something very promising here," said Dr. Michael Lederman, one of the key collaborators on the project and the director of the Case Center for AIDS Research based at University Hospitals.
"We have been effectively dealing with those challenges and resolving them. That is what it takes to develop a strategy. When we started this, no one thought this would make any sense."
The three cheaper versions were found using a relatively new technique that generates a vast pool of like-minded biological candidates bearing some resemblance to the Rantes molecule. Not only did these molecules appear to be just as good as the Rantes molecule in preventing viral entry into cells, but they also didn't come with the complicated assembling instructions of their Cadillac-style cousin.
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http://blog.cleveland.com/metro/2008/02/case_western_reserve_universit.html