Pharmcos envy.... our saving grace... really.

[HysteryDiagnosis]

DO YOU REALIZE JUST WHAT ALL OF THIS MEANS????? If not ask someone with a biology background to interpret. What it means to me is that nature has and had all the answers all along, and it was only the profiteering pharmcos who made it into some sort of club where they were the only ones allowed in the game, and that they were the only ones who could provide the answers. Pure and unadulterated BS.

Mind you... this is an EXTRACT OF CABBAGE. Not some freaking chemical that the body is not used to, the liver cannot decipher, or the world doesn't need.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15517869
1: Anticancer Res. 2004 Sep-Oct;24(5A):2649-56. Related Articles, Links
Apoptosis in cervical cancer cells: implications for adjunct anti-estrogen therapy for cervical cancer.
Chen D, Carter TH, Auborn KJ.
North Shore-Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA.
>>CONCLUSION: Estrogen protects cervical cancer cells treated with DNA-damaging agents; UVB, mitomycin-C and cisplatin, from apoptotic death. For I3C, which induces apoptosis and is anti-estrogenic, the amount of apoptosis versus survival and the level of Bcl-2 depend on the I3C/estradiol ratio.<<

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15570059
1: J Nutr. 2004 Dec;134(12 Suppl):3493S-3498S. Related Articles, Links
Click here to read
Indole-3-carbinol and prostate cancer.
>>In conclusion, the results from our laboratory and from others provide ample evidence for the benefit of I3C and DIM for the prevention and the treatment of prostate cancer.<<

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15611077
J Biol Chem. 2004 Dec 20; Related Articles, Links
Click here to read
Indole-3-carbinol (I3C) inhibits cyclin dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms and subcellular localization of the CDK2 protein complex.

Garcia HH, Brar GA, Nguyen DH, Bjeldanes LF, Firestone GL.

Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720-3200.

Indole-3-carbinol (I3C), a dietary compound found in cruciferous vegetables, induces a robust inhibition of CDK2 specific kinase activity as part of a G1 cell cycle arrest of human breast cancer cells. Treatment with I3C causes a significant shift in the size distribution of the CDK2 protein complex from an enzymatically active 90 kDa complex to a larger 200 kDa complex with significantly reduced kinase activity.

[ayeshahaqqiqa]

1. guess this means they'll make cabbage illegal

after all, its something any home gardener can grow-where is the profit for the drug companies? Reminds me of another plant that has helped many through medical crises....

[HysteryDiagnosis]

3. I have heard of people being sent home to hospice only to get a juicer,

organically grown cruciferous veggies and return to health.

This is something that the pharmcos do not want spread around, trust me. And this person simply bought a juicer... I am talking about purified Indole-3-Carbinol with DIM. And that is just "one" powerful anti-cancerous plant derived chemical. I only posted links to a few I3C papers at the NIH, there are dozens and dozens. Check it.

Just enter I3C in the window. Be amazed.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed

[TexasBushwhacker]

2. I have a biology background

Up to half of all drugs manufactured today have some basic in phytochemistry (compounds from plants). That's one of the reasons that our rapidly shrinking rainforests are such a concern. There are plants there that haven't been discovered and haven't been studied. Undoubtedly, there are cures and treatments for all sorts of diseases in the unstudied plants of the rainforest. As the rainforest shrinks, so do the populations of the indigenous people that live in it. There is a wealth of knowledge in the shamans and medicine men of these tribes that must be "harvested" before those people are also extinct.

Pharmcos employ pharmacobotanists that do nothing but study plants for possible medicinal value. They pay for the research. They pay for them to go down to the rainforests and bring back new plants to be studied.

I'd beat on the Pharmcos for some things, but not this. I would note however, that just because it comes from plants doesn't mean that it can't have bad effects on the body. There are plenty of phytotoxins out there too.

[idiosyncratic]

5. Did you read "Tales of the Shaman's Apprentice" by Mark Plotkin?

It is a very interesting book about his adventures as an ethno-botanist.

Tales of the Shaman's Apprentice

[HysteryDiagnosis]

7. Wierd... your link opens up as a Google search page with http in the

window... mighty strange.

[idiosyncratic]

8. Try it now . . . n/t

[HysteryDiagnosis]

9. Better. n/t

[TexasBushwhacker]

11. Thanks

It's now on my "to read" list.

[HysteryDiagnosis]

6. I am talking about one phytochemical, with properties too numerous to

list... positive effects on prostate cancer cell, breast cancer cell and cervical cancer cell apoptosis. Inhibition of carcinogenesis by HPV, yada yada yada. My point is that there are safe and effective supplements out there, have been for years, with tremendous liver protective properties, tremendous anti-viral properties, etc etc that have been totally ignored by the pharmcos simply because they do not "own" them. For this reason, hundreds of thousands have died before their time.

ALL DRUGS ARE TOXIC, whether derived from plants or coal tar.

Most foods have toxic metabolites that are handled by the liver... which is only stressed more when a person is adding chemicals/drugs to their regimen, making this natural supplement (below) all the more necessary in today's toxic environment.

Foods and their toxic metabolites:
http://www.nutramed.com/foodquality/foodchemistry.htm
Problems in Food
Naturally Occurring Toxins
Many non-nutrient natural substances in "natural" foods behave badly. We can think of their activity as chemically stressful. Chemical or molecular stressors increase chaos and decrease orderly, sensible body function. A chemical stressor is a bit of nonsense, a substance with no meaningful role to play or a toxic role that is destructive. In this review, a brief profile of stressors and toxins is developed more to illustrate the role of natural chemical stressors than to exhaust this vast and complicated subject.

BTW, Silymarin is another name for the simple herb Milk Thistle

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15586237
Silymarin and skin cancer prevention: Anti-inflammatory, antioxidant and immunomodulatory effects (Review).

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14965263
Prostate cancer prevention by silibinin.
Several epigenetic alterations leading to constitutively active mitogenic and cell-survival signaling, and loss of apoptotic response are causally involved in self-sufficiency of prostate cancer (PCA) cells toward uncontrolled growth, and increased secretion of pro-angiogenic factors. Therefore, one targeted approach for PCA prevention, growth control and/or treatment could be inhibition of epigenetic molecular events involved in PCA growth, progression and angiogenesis. In this regard, silibinin/silymarin (silibinin is the major active compound in silymarin) has shown promising efficacy.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12816629
Milk thistle: is there a role for its use as an adjunct therapy in patients with cancer?
Division of Pediatric Oncology, Columbia University, New York, NY, USA. [e-mail]

The use of complementary and alternative medicine (CAM) is common among patients with cancer. Many of these patients use CAM therapies to decrease the risk of late effects that are sometimes associated with cancer therapy. Certain classes of effective anticancer agents can induce short- and long-term toxicity to the liver. Currently, there are no safer alternatives to these medications. Milk thistle (Silybum marianum) is a botanical that may be useful in the prevention or treatment of liver dysfunction in patients undergoing anticancer therapy.

Publication Types:

* Review
* Review, Tutorial


PMID: 12816629

[TexasBushwhacker]

10. Pharmaceutical companies are businesses

and businesses have to stay profitable or they'll go out of business. However, there are a great many things that they do that PISS ME OFF such as:

1) Advertise their newest (therefore non-generic) drugs to the general population so that people go to their doctor and ask for "Vioxx" or "Lipitor" when there are older, safer, cheaper drugs out there that are just as effective. Of course, ultimately I blame the doctors that write the prescriptions. If they kept up on their study of the latest and greatest drugs, they could and should make better decisions.

Somewhere in the history of television advertising, someone made a decision that anything stronger than wine could not be advertised on TV. Well, the the Vioxx disaster, maybe it's time we talk to the FCC about prescription drug advertising on television.

2) Pharmcos spending their research dollars all coming up with different versions of the same thing. Okay, first they had Viagra, but do we really need Levitra and Cialis too. With the SSRI anti-depressants, first there was Prozac, then Zoloft, then Paxil, then Luvox, then Celexa and Lexapro. SSRI's have helped a lot of people and I realize that there are small differences between these drugs. But I'd bet that the drug companies are still developing NEW SSRI's so that they can keep raking in the non-generic bucks.

3) To the medical research community in general, starting studying more HEALTHY people. Find out what makes them different. So much time and money is spent studying sick people and trying to find cures, and lets face it, that kind of keeps the medical providers and pharmaceutical companies in business. Heaven forbid we should find out the real CAUSES of the diseases people have and do something about that! What on earth would we do if everyone stayed healthy and only had to go to doctors for the occasional injury or infection? Our whole medical system in the US seems to be set up to take care of chronic incurable diseases, while millions go without the basic healthcare that might prevent some of those chronic diseases. IT'S NUTS!

[HysteryDiagnosis]

12. It is simply not a healthcare system, it is a disease care system because

only disease is profitable. If healthcare was dependant on patented natural substances and could be sold for hundreds and thousands of dollars, the medical profession could/would become a healthcare system.

>>SSRI's have helped a lot of people<<

So have Omega Three oils, 5-Hydroxy-tryptophan, S-Adenosylmethioninie, Pycnogenol, etc etc.

I knew what these guys are publishing 10 years ago. Others knew it way before then... yet the pharmcos and the media remain mute on the subject. They should be held accountable for such egregious behavior (sp)

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15279495
1: Nutr Neurosci. 2004 Apr;7(2):91-9. Related Articles, Links

Effects of fish oil on the central nervous system: a new potential antidepressant?

Naliwaiko K, Araujo RL, da Fonseca RV, Castilho JC, Andreatini R, Bellissimo MI, Oliveira BH, Martins EF, Curi R, Fernandes LC, Ferraz AC.

Laboratorio de Fisiologia e Farmacologia do Sistema Nervoso Central, Departamento de Fisiologia e Farmacologia, Universidade Federal do Parana, 81.531-990 Curitiba, PR, Brazil.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15253674
1: Altern Med Rev. 2004 Jun;9(2):107-35. Related Articles, Links
Bipolar disorder and cell membrane dysfunction. Progress toward integrative management.
Kidd PM.
University of California, Berkeley, PhD, cell biology; contributing editor, Alternative Medicine Review; health educator; biomedical consultant to the dietary supplement industry. Correspondence address: 847 Elm Street, El Cerrito, CA 94530.

[HysteryDiagnosis]

13. Ya know what.... I should just put the entire paper up here.....

1: Altern Med Rev. 2004 Jun;9(2):107-35. Related Articles, Links
Click here to read
Bipolar disorder and cell membrane dysfunction. Progress toward integrative management.

Kidd PM.

University of California, Berkeley, PhD, cell biology; contributing editor, Alternative Medicine Review; health educator; biomedical consultant to the dietary supplement industry. Correspondence address: 847 Elm Street, El Cerrito, CA 94530.

Bipolar disorder (BD) is characterized by periods of abnormally elevated mood (mania) that cycle with abnormally lowered mood (depression). Multiple structural, metabolic, and biochemical abnormalities are evident in the brain's cortex, subcortex, and deeper regions. This disorder is highly genetically conditioned but also highly susceptible to environmental stressors: prenatal or perinatal insults, childhood sexual or physical abuse, challenging life events, substance abuse, and other toxic chemical exposures. Its high morbidity, lost productivity, and suicide risk place a great toll on society. Since World War II, BD has been steadily worsening with earlier age of onset, greater intensity of symptoms, and development of drug resistance. Incidence in children is rising and misdiagnosis is common. Disciplined management of the many risk factors is essential, including cognitive psychotherapy and support from family and community. Lithium has been the foundational treatment, followed by valproate and other mood stabilizers, antidepressants, and anticonvulsants.

Several single-nutrient and multinutrient supplements have also proven beneficial. Controlled, double-blind trials show multinutrient combinations of vitamins, minerals, orthomolecules, herbals, and the omega-3 fatty acids EPA and DHA to be effective monotherapy. The molecular action of lithium and valproate converge with nutrients on the level of the cell membrane and its molecular signal transduction systems.

This emergent, unified rationale presages effective integrative management of bipolar disorder.

PMID: 15253674

[TexasBushwhacker]

14. I know of many psychiatrists that recommend

fish oil and other supplements to their patients with depression and bi-polar disorder, my shrink included. However, once a person goes to a psychiatrist, they're usually in pretty bad shape. Fish oil and B Vitamins is probably not going to get them out of a suicidal depression or a manic episode. Once stabilized, a person may be able to manage their depression or bi-polar disorder with OTC supplements alone, or maybe not. Unfortunately, the way our health insurance system is set up, it will probably be cheaper for a person to take Litium and Valporate than it is for them to take fish oil and other supplement, and that's not right.

AND ANOTHER THING!

This article also mentions:

"Disciplined management of the many risk factors is essential, including cognitive psychotherapy and support from family and community."

My health insurance pays for my anti-depressants, but I have a $2000 deductible for out-patient therapy, even though I could produce dozens of research studies showing that the combination of medication and therapy is the MOST effective treatment of long term depression. But, as you said, our healthcare system is set up to treat people forever, not make them WELL.

[TahitiNut]

4. The common cruciferous vegetables are broccoli, cauliflower, cabbage, ...

... Brussels sprouts, bok choy and kale.


Arugula
Bok choy
Broccoli
Brussels sprouts
Cabbage
Cauliflower
Chinese cabbage
Collard greens
Daikon
Kale
Kohlrabi
Mustard greens
Radishes
Rutabaga
Turnips
Watercress