http://www.medscape.com/viewarticle/521939You may need to register with medscape to access this article. It came right up for me through my email account, account, though.
Calorie-Restricted Diet Curbs Normal Human Cardiovascular Aging News Author: Megan Rauscher
CME Author: Charles Vega, MD, FAAFP
Jan. 20, 2006 —
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The cardiac-specific beneficial effects of caloric restriction appear to be mediated by reductions in blood pressure, systemic inflammation, and myocardial fibrosis, the study team reports in the January 17th issue of the Journal of the American College of Cardiology.
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The calorie-restricted diet consisted of roughly 1,671 kcal per day derived approximately 23% protein, 49% complex carbohydrates, and 28% fat (including 6% saturated fat). The Western diet consisted of roughly 2,445 kcal per day made up of about 17% protein, 52% carbohydrates, and 31% fat (11% saturated fat).
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Over the course of the study, the mean BMI of those on caloric restriction fell from 23.9 to 19.7, although their weight was stable for at least 6 months at the time of cardiac assessment. None of them performed more than 20 minutes of vigorous exercise twice weekly.
According to Dr. Fontana, "people who followed a severe calorie-restricted diet but with optimal nutrition had a younger heart in terms of diastolic function, which is a well-accepted marker of primary aging because, independently of disease, as you get older your diastolic function gets worse and worse."
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