Israeli medical expert addresses UK audience

[Behind the Aegis]

Leading figures from the medical and pharmaceutical world attended a breakfast meeting in central London last week to hear Professor Moussa Youdim, director of the Eve Topf Neurodegenerative Diseases Centre at the Technion, Haifa and a world-renowned expert in the development of drugs to treat Alzheimer’s and Parkinson’s disease.

The event, hosted by law firm Mishcon de Reya, had a live video link-up to Prof Youdim in Israel. Professionals from hospitals across London as well as research universities and leading pharmaceutical companies took part in the round table discussion.

Rare discovery

Prof Youdim talked about his discovery of Rasagiline, a new drug which marks a major breakthrough in the treatment of Parkinson’s disease. The drug was made available in the UK last year by Teva Pharmaceuticals, under the brand name Azilect.

In a study of 687 Parkinson’s patients from Israel, Argentina and Europe, Azilect and Entracapone were compared when used with the drug Levodopa.

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[Name removed]

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[Coastie for Truth]

2. Here's an overview of Youdim's current peer reviewed research

1. Youdim MB, Fridkin M, Zheng H., Novel bifunctional drugs targeting monoamine oxidase inhibition and iron chelation as an approach to neuroprotection in Parkinson's disease and other neurodegenerative diseases. J Neural Transm. 2004 Oct;111(10-11):1455-71. Epub 2004 Apr 20

2. Frolich L, Gotz ME, Weinmuller M, Youdim MB, Barth N, Dirr A, Gsell W, Jellinger K, Beckmann H, Riederer P., (r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia. J Neural Transm. 2004 Mar;111(3):295-310. Epub 2003 Oct 24.

3. Youdim MB, Amit T, Bar-Am O, Weinstock M, Yogev-Falach M., Amyloid processing and signal transduction properties of antiparkinson-antialzheimer neuroprotective drugs rasagiline and TV3326. Ann N Y Acad Sci. 2003 May;993:378-86; discussion 387-93.

4. Weinreb O, Mandel S, Youdim MB., Gene and protein expression profiles of anti- and pro-apoptotic actions of dopamine, R-apomorphine, green tea polyphenol (-)-epigallocatechine-3-gallate, and melatonin. Ann N Y Acad Sci. 2003 May;993:351-61; discussion 387-93.

5. Finberg JP, Lamensdorf I, Commissiong JW, Youdim MB. Pharmacology and neuroprotective properties of rasagiline.J Neural Transm Suppl. 1996;48_95-101

Youdim has been looking at Human Growth Hormone derivatives and Insulin derivatives and their effect on dopamine and on amylase.

[barb162]

3. I am really, really glad you posted this very important article in I/P