Antioxidant Supplementation Not Assoc. w/ Lower Risk of Prostate Cancer

[kerouac]

16-Feb-2006

Study: Antioxidant Supplementation Not Associated With Decreased Risk of Prostate Cancer

February 2006 - Intakes of dietary or supplemental antioxidants were not associated with a decreased risk of prostate cancer among men in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, according to a study in the February 15 issue of the Journal of the National Cancer Institute . The study did find that vitamin E and beta-carotene supplementation may be associated with reduced prostate cancer risk in certain population subgroups.

http://thediabeticnews.com/news/877.shtml


Also related:

16-Feb-2006

Study: Saw Palmetto No Better Than Placebo For Enlarged Prostate

February 2006 - Saw palmetto, an herbal extract commonly taken to improve urinary symptoms in men with enlargement of the prostate gland, is no more effective than a placebo, according to a new study.

http://thediabeticnews.com/news/878.shtml

[BuddhaGirl]

1. whatever

Saw palmetto can't be patented and costs way less than pharmaceutical drugs that are used to treat BPH. hhmmmm!

since my husband started taking saw palmetto, he doesn't have to get up as much during the night and no longer pees in "morse code" when he does.

[Celebration]

4. studies

This study (saw palmetto) was done on moderate to severe symptoms, but using the same dosage that had been effective earlier in mild to moderate symptoms. So obviously more studies are needed. The dosage was probably ineffective for the more severe symptoms--or perhaps saw palmetto only helps those with mild to moderate symptoms. This study brings up more questions than it answers.

[RedOnce]

5. Yes, here is the 2001 Saw Palmetto Study...

2001 Dec;58(6):960-4; discussion 964-5.

Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms.

Gerber GS, Kuznetsov D, Johnson BC, Burstein JD.

Section of Urology, Department of Surgery, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA

OBJECTIVES: To assess the effects of saw palmetto on urinary symptoms, sexual function, and urinary flow rate in men with lower urinary tract symptoms using a double-blind, randomized, placebo-controlled trial. METHODS: The eligible patients were 45 years of age or older and had an International Prostate Symptom Score of 8 or greater. After a 1-month placebo run-in period, 85 men were randomized to receive saw palmetto or placebo for 6 months. Patients were evaluated using the International Prostate Symptom Score, a sexual function questionnaire, and by measurement of the urinary flow rate. RESULTS: The mean symptom score decreased from 16.7 to 12.3 in the saw palmetto group compared with 15.8 to 13.6 in the placebo group (P = 0.038). The quality-of-life score improved to a greater degree in the saw palmetto group, but this difference was not statistically significant. No change occurred in the sexual function questionnaire results in either group. The peak flow rate increased by 1.0 mL/s and 1.4 mL/s in the saw palmetto and placebo groups, respectively (P = 0.73). CONCLUSIONS: Saw palmetto led to a statistically significant improvement in urinary symptoms in men with lower urinary tract symptoms compared with placebo. Saw palmetto had no measurable effect on the urinary flow rates. The mechanism by which saw palmetto improves urinary symptoms remains unknown.

PMID: 11744467

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11744467&dopt=Citation

[RedOnce]

6. Here is the 2002 Long-Term Saw Palmetto study...

Permixon is a brand of standardized saw palmetto extract sold widely in Europe.

2002 Nov-Dec;19(6):297-306.

Long-term clinical and biologic effects of the lipidosterolic extract of Serenoa repens in patients with symptomatic benign prostatic hyperplasia.

Pytel YA, Vinarov A, Lopatkin N, Sivkov A, Gorilovsky L, Raynaud JP.

Scientific Research Institute of Urology, Moscow, Russia.

Permixon, the lipidosterolic extract of Serenoa repens, is widely used for the treatment of symptoms associated with benign prostatic hyperplasia (BPH). This open study assessed the efficacy and tolerability of Permixon 160 mg twice daily administered for 2 years. One hundred fifty-five men with clinically diagnosed BPH and complaints of prostatic symptoms were enrolled in the study. At 6, 12, 18, and 24 months, the International Prostate Symptom Score (I-PSS), quality of life, and sexual function score were recorded, and urodynamics and biologic values were measured. Adverse events were recorded every 3 months. I-PSS and quality of life improved significantly from baseline at each evaluation time point. At the end of the study and at each evaluation, maximum urinary flow also improved significantly. Prostate size decreased. Sexual function remained stable during the first year of treatment and significantly improved (P = .001) during the second year. Prostate-specific antigen was not affected, and no changes in plasma hormone levels were observed. Nine patients reported 10 adverse events, none related to treatment. Improvements in efficacy parameters began at 6 months and were maintained up to 24 months. These data demonstrate the long-term efficacy and tolerability of Permixon and support its use as a first-line medical therapy for uncomplicated symptomatic BPH.

PMID: 12665050

[beam me up scottie]

2. Hey, that's a great site.

Thanks for posting this, it's hard to find sites that are unbiased in their criticism.

[RedOnce]

3. Rutgers - Curry and Cauliflower Could Halt Prostate Cancer

January 15, 2006

NEW BRUNSWICK/PISCATAWAY, N.J. – Rutgers researchers have found that the curry spice turmeric holds real potential for the treatment and prevention of prostate cancer, particularly when combined with certain vegetables.

The scientists tested turmeric, also known as curcumin, along with phenethyl isothiocyanate (PEITC), a naturally occurring substance particularly abundant in a group of vegetables that includes watercress, cabbage, winter cress, broccoli, Brussels sprouts, kale, cauliflower, kohlrabi and turnips. “The bottom line is that PEITC and curcumin, alone or in combination, demonstrate significant cancer-preventive qualities in laboratory mice, and the combination of PEITC and curcumin could be effective in treating established prostate cancers,” said Ah-Ng Tony Kong, a professor of pharmaceutics at Rutgers, The State University of New Jersey.

The discovery was announced in the Jan. 15 issue of the journal Cancer Research by Kong and his colleagues at Rutgers’ Ernest Mario School of Pharmacy.

The authors noted that in contrast to the high incidence of prostate cancer in the United States, the incidence of this disease is very low in India. This has been attributed to the dietary consumption of large amounts of plant-based foods rich in phytochemicals – nonnutritive plant chemicals that have protective or disease-preventive properties.

http://ur.rutgers.edu/medrel/viewArticle.html?ArticleID=4912

[JohnWxy]

9. I3C & DIM Natural, Dual-Action Protection Against Deadly Cancers

http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=4030&query=PROSTATE%20INDOLE3CARBINOL&hiword=INDOLE3CARBINOL%20INDOLE3CARBINOLS%20PROSTA%20PROSTATE%20PROSTATES%20PROSTATIC%20PROSTATIS%20

"An often overlooked member of the cruciferous vegetable family, watercress is an “exceptionally rich source”59 of potent cancer-fighting isothiocyanates, including a much-studied compound known as phenethyl isothiocyanate, or PEITC."

[JohnWxy]

7. Do you know how long the study on Prostate Cancer was conducted?

i didn't find anything stating how long the groups were monitored. I would think with any period less than 10 years it would be difficult to see any significant changes at all.

[JohnWxy]

8. PSA, prostate cancer and Lycopene, Saw Palmetto and Beta Sitosterol

"Until now, PSA has been viewed only as a blood indicator of prostate cancer, infection, or inflammation. Emerging evidence, however, reveals that PSA may be more than just a marker of prostate health. It appears that PSA itself may play a role in the progression and metastasis of prostate cancer,1-3 thus opening up new therapeutic pathways for preventing and treating this epidemic disease."


PSA and Lycopene

Beta Sitosterol, Saw Palmetto

[JohnWxy]

10. Prostate Cancer and Beta Sitosterol, Saw Palmetto and Lycopene

http://www.democraticunderground.com/discuss/duboard.php?az=view_all&address=222x4624

[philb]

11. Hulda Clark and others found nickel is usually a big factor in prostate ca

cancer- often from dental crowns, etc.

Hulda Clark, The Cure of All Diseases, New Century Press, 1995.
More documentation at http://www.home.earthlink.net/~berniew1/amalg6.html

Her recommendations:
(nickel: histidine as chelator, zinc, flax oil) dental & diet cleanup(mercury & cavitations can also be a factor)
support the immune system