Pulmonary Hypertension

[HysteryDiagnosis]

Please notice the "which may" at the bottom of this paper. It's very hard indeed for the ignored to acknowledge that naturally occurring substances could have effects such as these.

http://www.ncbi.nlm.nih.gov/pubmed/19597040?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus
1: Hypertension. 2009 Sep;54(3):668-75. Epub 2009 Jul 13.Click here to read Links

Comment in:
Hypertension. 2009 Sep;54(3):473-4.

Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.
Csiszar A, Labinskyy N, Olson S, Pinto JT, Gupte S, Wu JM, Hu F, Ballabh P, Podlutsky A, Losonczy G, de Cabo R, Mathew R, Wolin MS, Ungvari Z.

Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.

Proliferation of pulmonary arterial smooth muscle cells, endothelial dysfunction, oxidative stress, and inflammation promotes the development of pulmonary hypertension. Resveratrol is a polyphenolic compound that exerts antioxidant and anti-inflammatory protective effects in the systemic circulation, but its effects on pulmonary arteries remain poorly defined. The present study was undertaken to investigate the efficacy of resveratrol to prevent pulmonary hypertension. Rats injected with monocrotaline progressively developed pulmonary hypertension. Resveratrol treatment (25 mg/kg per day, PO, from day 1 postmonocrotaline) attenuated right ventricular systolic pressure and pulmonary arterial remodeling, decreased expression of inflammatory cytokines (tumor necrosis factor-alpha, interleukin 1beta, interleukin 6, and platelet-derived growth factor-alpha/beta), and limited leukocyte infiltration in the lung.

Resveratrol also inhibited proliferation of pulmonary arterial smooth muscle cells. Treatment of rats with resveratrol increased expression of endothelial NO synthase, decreased oxidative stress, and improved endothelial function in small pulmonary arteries. Pulmonary hypertension was associated with an upregulation of NAD(P)H oxidase in small pulmonary arteries, which was significantly attenuated by resveratrol treatment. Our studies show that resveratrol exerts anti-inflammatory, antioxidant, and antiproliferative effects in the pulmonary arteries, which may contribute to the prevention of pulmonary hypertension.

[Tangerine LaBamba]

1. See? I knew it!

I've been saying this all along, but no one believed it because I was wearing my Harvard sweatshirt.

People can be such reverse snobs, I swear.....................

[HysteryDiagnosis]

2. What in the world are you typing about??? n/t

[BoneDaddy]

3. my guess is that he felt the same way

about your post

[HysteryDiagnosis]

4. ... trouble with reading comprehension?

[BoneDaddy]

5. Wow, did you have a bad day?

Or are you just a ornery fool who cuts and pastes from medical journals?

Edit: My guess is you are a first year med student who thinks a little knowledge actually impresses people.

[Tangerine LaBamba]

7. No one here has trouble with reading compre-

hension.

And your expertise with cutting and copying is impressive.

I'm sure you had a point - known only to you - in posting this cut-and-copy job, but I'm also sure you're the only one to whom that meaning has been revealed..............................

[Why Syzygy]

9. Isn't it better to

cut and paste something rather than just post a blind link OR WORSE a link to another DU forum?
I think it is. That's just me.

[Tangerine LaBamba]

11. Oh, that crap -

posting the link with some sort of cryptic Subject Line, or, as you note, a link to another DU forum is as annoying as the people who post stuff that means something only to them - i.e., "I just saw my reflection in the bathroom mirror, and, boy, am I gorgeous!"

No matter what the set-up, when something bizarre is posted without explanation, it demands response.

That's just me.................:)

[Why Syzygy]

13. I say something nice.

Once. For repeat offenders, I just unrec 'em. ;)

[Tangerine LaBamba]

15. THAT's what Unrec is for!!!

It never occurred to me.

Thank you. That's EXACTLY right, and I never even thought of it.

Thank you!

[Why Syzygy]

17. Remember Canada!

:hi: I'm packing my Maple Leafs.

[Tangerine LaBamba]

6. Took the words

right out of my ...... uh .............. off my keyboard.

Thank you................

[Why Syzygy]

8. No. I think TL is a wine drinker. nt

[Tangerine LaBamba]

12. Actually,

TL doesn't drink...........

[Why Syzygy]

14. Neither does Syz.

The Harvard sweat shirt was a red herring! I thought you were referring to Resveratrol being derived from wine.
Oh well.

[Tangerine LaBamba]

16. You're too smart

for your own good, smartiepants...................:hi:

[EmeraldCityGrl]

10. I have PAH. Thank you for the article.

This disease is a killer and this is very promising research.

:toast:

[HysteryDiagnosis]

18. My op was intentionally cryptic. My intent is to show that perhaps,

just perhaps some naturally occurring substances that BELONG in the human body, when in short supply.... RESULT IN UNRESTRAINED INFLAMMATION, IMMUNE SYSTEM ACTIVITY/IMBALANCE etc. In other words... what is coming out is very positive for all of us.... and resveratrol is cool. Better taken in supplement form... that is if you drive a vehicle or if you need to be cognizant on the job.

[BoneDaddy]

19. Ahhh....the ever captivating, stimulating

cryptic medical study posts... I get it now. This is a pitch for the next Dan Brown movie... how fucking careless of me.... Sorry bro/sis, I TOTALLY get it now...its the Freemasons

[HysteryDiagnosis]

20. Bwahahahahahahaaaaa.... you don't get anything. n/t

[BoneDaddy]

21. Wow some things are lost on others

nice come back

[HysteryDiagnosis]

22. Lost yes... but not forgotten.

[BoneDaddy]

23. what were we talking about?

?

[HysteryDiagnosis]

24. Me and you?? Nuttin honey....

[BoneDaddy]

25. I wasn't talking to you

i meant the other idiot

[HysteryDiagnosis]

27. My bad.... but that makes me the other other idiot. Not good. n/t

[Fire_Medic_Dave]

26. They treat it with Viagra if I'm not mistaken.