Indole Three Carbinol.... for the invitro vs invivo flap

[HysteryDiagnosis]

Indole three carbinol with DIM, look for it at better health food stores everywhere.... 300mg/day is what I remember hearing was a good protocol for prevention, as for treatment of an already existing cancer, I will leave that to the experts.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16557333&query_hl=1&itool=pubmed_docsum

1: Mol Med. 2006 Mar 22; Related Articles, Links
Click here to read
Indole-3-Carbinol Prevents PTEN Loss in Cervical Cancer In Vivo.

Qi M, Anderson AE, Chen DZ, Sun S, Auborn KJ.

Feinstein Institute for Medical Research, Manhasset, NY, USA.

Indole-3-carbinol (I3C) is a phytochemical (derived from broccoli, cabbage, and other cruciferous vegetables) with proven anticancer efficacy including the reduction of cervical intraepithelial neoplasia (CIN) and its progression to cervical cancer. In a breast cancer cell line, I3C inhibited cell adhesion, spreading, and invasion associated with an upregulation of the tumor suppressor gene PTEN, suggesting that PTEN is important in inhibition of late stages in the development of cancer. The goal of this study was to determine the expression of PTEN during the development of cervical cancer and whether I3C affected expression of PTEN in vivo. We show diminished PTEN expression during the progression from low-grade to high-grade cervical dysplasia in humans and in a mouse model for cervical cancer, the K14HPV16 transgenic mice promoted with estrogen. The implication is that loss of PTEN function is required for this transition. Additionally, dietary I3C increased PTEN expression in the cervical epithelium of the transgenic mouse, an observation that suggests PTEN upregulation by I3C is one mechanism by which I3C inhibits development of cervical cancer.

PMID: 16557333

[BuddhaGirl]

1. Interesting! I take DIM daily

it helps channel xenoestrogens out of your body. It also has had a positive effect on my PMS symptoms.