Genetic Studies Reveal New Causes of Severe Obesity in Childhood

[n2doc]

ScienceDaily (Dec. 7, 2009) — Scientists in Cambridge have discovered that the loss of a key segment of DNA can lead to severe childhood obesity. This is the first study to show that this kind of genetic alteration can cause obesity. The results are published December 6 in Nature.


The study, led by Dr Sadaf Farooqi from the University of Cambridge and Dr Matt Hurles from the Wellcome Trust Sanger Institute, looked at 300 children with severe obesity.

The team scanned each child's entire genome looking for types of mutation known as copy number variants (CNVs). CNVs are large chunks of DNA either duplicated or deleted from our genes. Scientists believe this type of mutation may play an important role in genetic diseases.

By looking for CNVs that were unique in children with severe obesity, compared with over 7,000 controls (apparently healthy volunteers from the Wellcome Trust Case Control Consortium 2), they found that certain parts of the genome were missing in some patients with severe obesity.

According to Dr Farooqi: "We found that part of chromosome 16 can be deleted in some families, and that people with this deletion have severe obesity from a young age.

"Our results suggest that one particular gene on chromosome 16 called SH2B1 plays a key role in regulating weight and also in handling blood sugar levels. People with deletions involving this gene had a strong drive to eat and gained weight very easily."

Dr Matt Hurles adds: "This is the first evidence that copy number variants have been linked to a metabolic condition such as obesity. They are already known to cause other disorders such as autism and learning difficulties."

more:

http://www.sciencedaily.com/releases/2009/12/091206162957.htm

[JonQ]

1. It said some of the children had this

but I couldn't find the exact number. I wonder what sort of correlation we're talking about here.

[kimmerspixelated]

2. Or maybe,

it's the sodas with every meal and other highly sugary meals and treats, fluoride treatments, in toothpaste and in some water(fluoride may prevent some cavities but is also in rat poison, and is/was once used to treat over-active thyroid). Maybe it's also the lifestyle of video games, etc., less exercise????

[supernova]

3. You seem to be suggesting

that childhood obesity could not possibly be caused by genetics. Not every person who is obese, including kids, has bad eating habits. That is the point of this article.

[kimmerspixelated]

4. Sorry, didn't mean to imply that genetics aren't a part,

But the American diet is generally horrible, and at least 68% responsible for the obesity crisis.