http://www.lef.org/whatshot/2010_10.htm#Garlic-shows-promise-for-protection-against-cardiomyopathyWei-Wen Kuo of China Medical University and colleagues evaluated garlic’s effects in rats in which diabetes was induced by the administration of streptozotocin. Ten, 50 or 100 milligrams garlic oil per kilogram body weight or corn oil was delivered by stomach tube every other day for 16 days. An additional group of nondiabetic rats served as controls.
Echocardiograms of the heart were performed before and 16 days following the administration of garlic, and apoptosis (programmed cell death) oxidative stress, and other factors were evaluated. Garlic oil significantly decreased cardiac contractile dysfunction induced by diabetes, with those that received the higher doses experiencing function similar to nondiabetic rats. Additionally, the decline in the antioxidant superoxide dismutase-1, and the increase in lipid peroxidation and apoptosis that was observed in the hearts of the diabetic animals was dose-dependently reduced in animals that received garlic. The benefits appear to be associated with garlic’s numerous antioxidant compounds.