Attacking Cancer's Sweet Tooth Is Effective Strategy Against Tumors

[Mr. McD]

As a tumor grows, cells crowd one another and may be cut off from oxygen-carrying blood vessels--a distinct disadvantage since most cells require oxygen to produce the bulk of their energy-storing adenosine triphosphate (ATP). In the 1920s, Otto Warburg proposed that some cancer cells evolved the ability to switch over to an ancient, oxygen-free route, the glycolytic pathway. What is more, they continue to use this pathway even when access to oxygen is restored. Though the so-called Warburg effect has since been confirmed, the role-played by glycolysis in cancer has been largely ignored. Few have attempted to attack specific points along the glycolytic pathway to gain a therapeutic effect.

http://www.sciencedaily.com/releases/2006/06/060630094933.htm

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
Cancer Cell, Volume 9, Issue 6, 13 June 2006, Pages 425-434

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WWK-4K5HMRH-4&_coverDate=06%2F13%2F2006&_alid=425758858&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=7133&_sort=d&view=c&_acct=C000059604&_version=1&_urlVersion=0&_userid=4427&md5=a082174e67a86aff62c1e942ba73ddd8

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WWK-4K5HMRH-2-1&_cdi=7133&_user=4427&_orig=browse&_coverDate=06%2F13%2F2006&_qd=1&_sk=999909993&view=c&wchp=dGLbVlb-zSkWb&md5=25d2cbcc8c8471b69d74eb5524d9ba55&ie=/sdarticle.pdf

Otto Warburg, a German physician was awarded a Nobel Prize over 75 years ago for first uncovering cancer cells' massive dependence on sugar as a fuel source.

http://www.newmediaexplorer.org/chris/2004/02/03/otto_warburg_cancer_and_oxygen.htm

Dietary Glycemic Load and Risk of Colorectal Cancer in the Women's Health Study
Journal of the National Cancer Institute, Vol. 96, No. 3, 229-233, February 4, 2004

http://jncicancerspectrum.oxfordjournals.org/cgi/content/abstract/jnci%3b96/3/229