Life-Lengthening Hormone Found in Mouse Research
By Rob Stein
Washington Post Staff Writer
Friday, August 26, 2005; Page A01
Scientists have identified a hormone that significantly extends the life span of mice, a discovery that could mark a crucial step toward developing drugs that boost longevity in people.
The hormone is the first substance identified that is produced naturally in mammals, including humans, and can extend life span -- a long-sought goal in the intense effort to help people live longer.
Much more work is needed to study the substance, and investigate whether the hormone or a similar compound would be effective and safe in people, experts cautioned. But the discovery opens highly promising avenues for research and provides tantalizing new clues toward deciphering the basic biology of aging.
"This is a significant discovery. It's an exciting paper," said Anna McCormick of the National Institute on Aging, which helped fund the new research, published online yesterday by the journal Science. "It's definitely the way you would go about designing molecules that would promote healthy aging and longevity in people."
Makoto Kuro-o of the University of Texas's Southwestern Medical Center at Dallas, who led the research, said, "This could provide a key to understanding the molecular mechanisms of aging and opens up new areas to the potential therapy for multiple age-related diseases in humans."...
http://www.washingtonpost.com/wp-dyn/content/article/2005/08/25/AR2005082501224.html