We had a lot of ghostly activity in our first house, as well as kind of "hot spots" that elicited particular feelings. For instance, the downstairs bathroom was Mr. MG's for all intents and purposes--it was where he got ready for work in the morning while I had the upstairs bathroom. And he told me that every morning while he was in the bathroom he'd get this very motherly, loving, supportive feeling, to the point where he believed he could do anything and everything he set his mind to. But it always stopped as soon as he left the bathroom.
My former elder came to check the house out, and even though I didn't tell her what Mr. MG had said, she picked up the presence of a motherly type woman hanging around our downstairs, around where the bathroom was. She also identified several other ghosts (like I said, a LOT of activity) as well as a vortex at our cobblestone fireplace.
So yes, a particular location can have an entity hanging around in that spot, and if it's carrying ickies, you're going to pick up on it. Or it could be an energy vortex.
I would recommend a thorough housecleaning. I detailed it in this post a while back:
http://www.democraticunderground.com/discuss/duboard.php?az=show_topic&forum=245&topic_id=66155#66169Holler if you need any assistance! :hi: