It was written when Meirs was the choice, but the info is just as good when applied to any "nuclear option" vote.
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In the 88 years since the adoption of Rule XXII, senators from both sides of the aisle have threatened the "nuclear" option more than a half-dozen times. Each time, the Senate has been loath to drop this particular bomb on its own house, and for good reason.
The rules of procedure adopted by the Senate are "the only weapon by which the minority can defend themselves" against "the irregularities and abuses … which the wantonness of power is but too often apt to suggest to large and successful majorities," as Thomas Jefferson warned. (T. Jefferson, A Manual of Parliamentary Practice, § I.)
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The Republicans should reconsider the nuclear option, given the ensuing fallout should it succeed. Under traditional parliamentary procedures, it is a violation of fair procedure to employ a motion to table in order to defeat a measure (Robert's Rules, pp. 207-209). This is so because permitting a motion to table to have this effect closes debate on a simple majority vote, when a two-thirds majority is required. Acting in defiance of this long-standing rule of parliamentary procedure would set a dangerous precedent, one the Republicans may find themselves chafing under in the future.
Prior to the Republican sweep of Congress and the White House, Sen. Frist and other Republicans proposing the gag measure freely invoked filibuster. For example, they filibustered six of President Clinton's judicial nominees, all of whom were ultimately appointed after they received a majority vote. Moreover, the Republican minority succeeded in blocking 60-plus nominees in committee. This tactic is unaffected by the proposed rule change, as are other similar types of filibuster, including placing a hold on a nomination, refusing to report a nomination out of committee, objecting to unanimous consent agreements, being absent during quorum calls, and voting against cloture.
http://www.law.com/jsp/article.jsp?id=1111781921564