Seven children doing well with laboratory-grown organs
Bladders were grown from the children's own cells
April 3, 2006
Three boys and four girls treated at Children's Hospital Boston are the first people in the world to receive laboratory-grown organs. The children, aged 4 to 19, received bladders grown from their own cells and have now been followed for an average of almost four years. Their cases are reported in the April 4th online edition of the journal The Lancet.
"This is one small step in our ability to go forward in replacing damaged tissues and organs," said Anthony Atala, MD, who began working on the technology in 1990 as director of Tissue Engineering for the Urology Program at Children's Hospital Boston. Atala now directs the Institute for Regenerative Medicine at Wake Forest University School of Medicine.
The process for growing each patient's organ began with a bladder biopsy to get samples of the outer muscle cells and the urothelial cells that line the bladder walls. These cells were grown in a culture in the laboratory until there were enough cells to place onto a specially constructed biodegradable mold, or scaffold, shaped like a bladder.
The cells continued to grow. Then, seven or eight weeks after the biopsy, the engineered bladders were sutured to patients' original bladders during surgery. The scaffold was designed to degrade as the bladder tissue integrated with the body. Scientists hope that laboratory-grown organs can one day help solve the shortage of donated organs available for transplantation.
"We have shown that regenerative medicine techniques can be used to generate functional bladders that are durable," said Atala, who also directs the National Regenerative Medicine Foundation.
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