US drugmaker Bristol-Myers Squibb and a subsidiary have agreed to pay more than $515m (£251.7m) to settle allegations of marketing certain drugs illegally.
The fines issued by the US Department of Justice mark the end of a probe into the firm's drug pricing practices that began a number of years ago.
The fine had already been provisionally agreed last December and the firm said it had reserved the money.
Bristol-Myers said there were no criminal charges against the company.
New York-based Bristol-Myers has endured a turbulent five-year period, including an accounting scandal and a lengthy investigation into allegedly dubious business practices.
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