is spreading around the Middle East.
The Health Effects of DU Weapons in Iraq.A Presentation by Thomas Fasy MD PhD, Mt. Sinai Medical School, New York.
Dr. Fasy is an Associate Clinical Professor of Pathology at the Mount Sinai School of Medicine in New York City. He has longstanding interests in carcinogenesis and environmental toxicology. In the past two years, he has lectured at conferences and university campuses on the toxic effects of inhaling uranium oxide dusts derived from depleted uranium weapons.SNIP
It is now clear that uranium has multiple toxicities. This slide summarizes some of the major toxicities of uranium.
By the early 1900s, uranium was well recognized to be a kidney toxin. By the mid-1940s, uranium was known to be a neurotoxin. By the early 1970s, uranium was recognized to be a carcinogen based on mortality studies of uranium workers and on experiments with dogs and monkeys. The first evidence that uranyl ions bind to DNA was reported in 1949 and by the early 1990s, uranium was shown to be a mutagen. Also, in the early 1990s, uranium was shown to be a teratogen, that is, an inducer of birth defects. The toxic effects of uranium on the kidney and on the nervous system typically occur within days of exposure and radiation probably plays little or no role in mediating these effects. In contrast, the carcinogenic effects of uranium have a delayed onset. The teratogenic effects of uranium might be due to exposure of one parent prior to conception as well as to exposure of the mother to uranium early in pregnancy.
Now let us briefly consider the routes of exposure to uranium. In the context of the dust particles derived from depleted uranium weapons, this means exposure to uranium oxides. By far the most dangerous route of exposure to uranium oxides is the inhalational or respiratory route. Absorption of uranium oxides through the gastrointestinal tract, the skin and the conjunctivae is possible but quite limited.
Following impact with hard targets, uranium metal undergoes combustion releasing large quantities of very small uranium oxide dust particles into the environment.
These dust particles derived from depleted uranium weapons are drastically different from the natural uranium that is normally present in rocks and soil.
Soil particles contain uranium at very low concentrations, typically less than 5 parts per million; the vast majority of these soil particles, however, are too large to be inhaled deep into the lungs. In contrast, the dust particles derived from depleted uranium weapons contain very high concentrations of uranium, typically more than 500.000 parts per million; moreover, most of the D.U. dust particles are sufficiently small to be inhaled deep into the lungs. Thus, compared to the uranium naturally present in the environment, D.U. dust contains uranium in a form that is vastly more bio-available and more readily internalized.
Uranyl ions bind to DNA; they bind in the minor groove of DNA. While bound to DNA, uranyl ions are chemically reactive and can give rise to free radicals which may damage DNA. Chemically mediated DNA damage of this type may contribute to the ability of uranium to induce cancers.
I would now like to present some epidemiologic data from the Basra governate in the south of Iraq. In February 1991, more than 300 tons (possibly much more than 300 tons) of D.U. weapons were used in South of Iraq. After 5-6 year latent periods, increases in childhood cancers and birth defects were documented in the Basra governate. The most recent data indicate a four fold increase in pediatric malignancies and a seven fold increase in congenital malformations compared to 1990, the year preceeding the war.
http://www.democraticunderground.com/discuss/duboard.php?az=show_topic&forum=104&topic_id=4124449 Uranium’s Effect On DNA Establishedby Kate Melville
The use of depleted uranium in munitions and weaponry is likely to come under intense scrutiny now that new research that found that uranium can bind to human DNA. The finding will likely have far-reaching implications for returned soldiers, civilians living in what were once war-zones and people who might live near uranium mines or processing facilities.
Uranium - when manifested as a radioactive metal - has profound and debilitating effects on human DNA. These radioactive effects have been well understood for decades, but there has been considerable debate and little agreement concerning the possible health risks associated with low-grade uranium ore (yellowcake) and depleted uranium.
Now however, Northern Arizona University biochemist Diane Stearns has established that when cells are exposed to uranium, the uranium binds to DNA and the cells acquire mutations, triggering a whole slew of protein replication errors, some of which can lead to various cancers. Stearns' research, published in the journals Mutagenesis and Molecular Carcinogenesis, confirms what many have suspected for some time - that uranium can damage DNA as a heavy metal, independently of its radioactive properties. "Essentially, if you get a heavy metal stuck on DNA, you can get a mutation," Stearns explained. While other heavy metals are known to bind to DNA, Stearns and her team were the first to identify this characteristic with uranium.
http://www.scienceagogo.com/news/20060307010324data_trunc_sys.shtml PRESENTATION TO THE EUROPEAN PARLIAMENT (23 June 2005)Keith Baverstock PhD; Department of Environmental Sciences, University of Kuopio, KUOPIO, Finland
I have, during a career of some 30 years, developed expertise in evaluating risks regarding the environmental and occupational exposure to ionising radiation and radioactive materials in many different situations. I have done this in the context of employment by the UK Medical Research Council (1971 to 1991) and the European Regional Office of the World Health Organisation (1991 to 2003), both ostensibly "independent" organisations.
Between 2000 and 2002 I examined the evidence relating to risks from the mildly radioactive depleted uranium. My concern was especially raised by the specific exposure context of inhalation of the dust particles produced when a depleted uranium munition impacts a hardened target and burns, producing fine particles of DU oxide (DUO). This material has no natural analogue and does not arise in the normal refining and processing of uranium for nuclear fuel. There is, therefore, no prior experience of exposure to this material than its use in Iraq in 1991.
According to the International Commission for Radiological Protection (ICRP), inhaled DUO would pose a hazard to the lung from radiation if it were insoluble and a chemical toxicity risk to the kidney (physiological toxicity of kidney malfunction) if it were soluble.
DUO is in fact part insoluble and part sparingly soluble. Since 1998 evidence has accrued that human cells exposed in the laboratory to low concentrations of DU exhibit changes characteristic of malignant cells and indeed, when implanted into host animals, will lead to malignancy. In these experiments it seems unlikely, given the low concentrations and the experimental conditions, that this effect is mediated by radiation, but is rather a chemically mediated genotoxicity. (See for example 1-6 The non-radioactive element, nickel, produces similar effects and is an established carcinogen.
In 2001 this evidence led me to believe that inhaled DUO particles, which are capable of penetrating the deep lung (where they would be retained for long periods) posed, for a period of weeks to months, not only a radiotoxicity risk but also a chemical genotoxicity risk and potentially a synergy between the two. Thus any risk evaluated on the basis of the ICRP recommendations would be likely to underestimate the true risk.
In addition, that DU is only mildly radioactive through alpha emission, raises the possibility of a further risk route mediated by the so called "bystander effect". (See for example; 7, 8) Here a single cell "hit" by an alpha particle sends signals to surrounding cells causing them to behave as if they had been irradiated. In circumstances where bystanders predominate (low dose exposure to alpha particles for example) the bystander effect acts to amplify the "radiation effect".
Thus, detailed examination of DUO reveals three potential risk routes in addition to the conventional radiotoxicity caused by direct irradiation, namely, chemical genotoxicity, synergy between radiation and chemical toxicities and a bystander route.
http://www.grassrootspeace.org/keith_baverstock_23june05.htm 
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