Viable Female and Male Mice from Two Fathers Produced Using Stem Cell Technology
ScienceDaily (Dec. 8, 2010) — Using stem cell technology, reproductive scientists in Texas, led by Dr. Richard R. Behringer at the M.D. Anderson Cancer Center, have produced male and female mice from two fathers.
The study was posted online Dec. 8 in the journal Biology of Reproduction.
The achievement of two-father offspring in a species of mammal could be a step toward preserving endangered species, improving livestock breeds, and advancing human assisted reproductive technology (ART). It also opens the provocative possibility of same-sex couples having their own genetic children, the researchers note.
In the new work, the Behringer team manipulated fibroblasts from a male (XY) mouse fetus to produce an induced pluripotent stem (iPS) cell line. About one percent of iPS cell colonies grown from this XY cell line spontaneously lost the Y chromosome, resulting in XO cells. The XO iPS cells were injected into blastocysts from donor female mice. The treated blastocysts were transplanted into surrogate mothers, which gave birth to female XO/XX chimeras having one X chromosome from the original male mouse fibroblast.
http://www.sciencedaily.com/releases/2010/12/101208151611.htm