Democratic Underground Latest Greatest Lobby Journals Search Options Help Login
Google

The claim of a "cure" for HIV is not just false, it is dangerous misinformation.

Printer-friendly format Printer-friendly format
Printer-friendly format Email this thread to a friend
Printer-friendly format Bookmark this thread
This topic is archived.
Home » Discuss » General Discussion Donate to DU
 
TheWraith Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 02:39 PM
Original message
The claim of a "cure" for HIV is not just false, it is dangerous misinformation.
Hat tip to La Lioness Priyanka for her similar thread earlier, but I wanted to be able to go at it and explain WHY this is the case in greater detail.

First, why it's false. One of the most important principles in scientific inquiry is reproducibility of results. You might be able to create something in a lab, but if you can't reliably reproduce it, it's useful only for academic research, not real world application.

In this case, the "cure" involved one man getting a bone marrow transplant from a donor with a genetic mutation known as CCR5-Delta32. CCR5-Delta32 is a gene which is most prevalent in people of northern European descent, because people with this gene have an increased natural resistance to certain diseases including bubonic plague, smallpox, and HIV. The belief is that the bone marrow in the man's body produced new blood cells which were immune to HIV, thus causing the virus to die out when it could no longer attack his blood cells.

The fact that this therapy "cured" one person is good for that person, but it is no guarantee that the same thing would work for another person. Even if it worked for multiple people, the scientists themselves say it cannot work universally, to cure everyone infected. And since this "cure" is based on finding an extremely rare type of bone marrow match, the chances of it being applied on even a mid-level scale is virtually non-existant.

So to say that this is a "cure" for HIV or AIDS is false and misleading. It's an interesting data point, and it may eventually contribute to us finding more effective treatments and preventions, but it is not even close to a cure.

Second, why it's dangerous. One of the trends we've seen in recent years is, after having plateaued at one point during the height of campaigns for HIV awareness and safe sex, a rise in the rate of new HIV infections. Many researchers attribute this to the creation of Highly-Active Anti-Retroviral Therapy and other anti-HIV/AIDS medications, because uninformed and underinformed people think of these as a "cure" for HIV/AIDS, or at the very least they serve to mitigate the public perception of the danger from HIV infection. As a result, people are less vigilant, and more likely to engage in unprotected sex, more people contracting the disease, and fewer people being careful enough to get tested.

This isn't just something dumb people do. I personally know someone who was diagnosed with AIDS a little over a year ago, after very nearly dying--he had a CD4 cell count of four, versus a viral load of about one million. He didn't find out he was infected until he reached the state known as "HIV-Associated Dementia." For those who don't know, imagine the virus getting so bad that, as it begins to attack your nervous system, it induces a delusional state akin to LSD on steroids. As a smart guy and an activist in the gay community, he should have known better than to get in that situation, either by getting infected or not knowing about it. He still took the risks.

The belief by the public that there is a "cure" for HIV can and will result in people, even smart people who know better, taking risks that they should not and would not if they were appropriately worried about infection. I understand people don't want to live in fear. But a little healthy fear is good for you. It makes you buckle up when you go out, eat healthy when you don't want to, and put the condom on even when you don't feel like it.
Printer Friendly | Permalink |  | Top
canetoad Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 02:44 PM
Response to Original message
1. Well said
K&R
Printer Friendly | Permalink |  | Top
 
Hello_Kitty Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 02:46 PM
Response to Original message
2. + Eleventybillion nt
Printer Friendly | Permalink |  | Top
 
CaliforniaPeggy Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 02:46 PM
Response to Original message
3. Exactly right.
Printer Friendly | Permalink |  | Top
 
The Backlash Cometh Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 02:47 PM
Response to Original message
4. That second part is especially relevant.
Printer Friendly | Permalink |  | Top
 
dipsydoodle Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 02:48 PM
Response to Original message
5. Well written and well put.
Edited on Wed Dec-15-10 02:49 PM by dipsydoodle
:thumbsup:

Fot others the "cure" may be as beneficial as tying a newt to the bedpost at night time.
Printer Friendly | Permalink |  | Top
 
Warpy Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 02:55 PM
Response to Original message
6. Nicely said. The best thing about the guy in Germany
is that he's pointed the way to a possible cure years in the future.

I'm still not convinced he is cured, though, since HIV is also well known to hide in nerve tissue including the brain. He could still present with brain tumors, something that happened with earlier bone marrow transplant HIV "cures."

What won't happen to him is the immune system collapse opening the door to every opportunistic infection out there.
Printer Friendly | Permalink |  | Top
 
TheWraith Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 03:34 PM
Response to Reply #6
12. True. It's an interesting case, and adds to our knowledge of how HIV behaves.
Which is valuable, and helps us narrow in on real, mass-application treatments.
Printer Friendly | Permalink |  | Top
 
northernlights Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 06:34 PM
Response to Reply #6
15. exactly
HIV can hide for some time in other tissues.

He may be cured...or he may simply have bought himself a chunk of time.
Printer Friendly | Permalink |  | Top
 
Hosnon Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 03:09 PM
Response to Original message
7. I think both points are extremely important. However, this still is big news.
To my knowledge, this is the first time the virus has been successfully removed from someone who was not naturally resistant to it. While it may have taken a bone marrow transplant to create the resistance, it is a huge step.

Before this, only humans with the natural immunity had this level of hope that they could be free from HIV. Now, that is not true.

But again, on the larger issues, I agree with you. This should not be mistaken as a cure for the average individual. The limits of this should be made extremely clear so reckless behavior does not increase.
Printer Friendly | Permalink |  | Top
 
TheWraith Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 03:15 PM
Response to Reply #7
8. Unfortunately, the limits are not being made clear, nor are they likely to be.
Scientific illiteracy is rampant in the media, not to mention sensationalism: "Cure for AIDS" is a much sexier and more readable story than "Cancer patient's bone marrow transplant confers immunity to HIV." Most reporters don't understand the facts, and they don't want to take the time to learn them. So we get stories--and not just scientific ones--that grossly mis-characterize reality. You get "Cure for AIDS," "Machine guns on the streets," "Democrat plan would raise taxes," etcetera.
Printer Friendly | Permalink |  | Top
 
thereismore Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 03:17 PM
Response to Original message
9. Let's put it this way: the doctors/scientists are not making the claims you are opposed to.
It's the sensational "reporters" again who do not know or do not care about science.

The fact itself is a very important scientific observable.
Printer Friendly | Permalink |  | Top
 
Vickers Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 03:22 PM
Response to Reply #9
10. +1
Every report I've seen has mentioned just the one guy, not some global cure.
Printer Friendly | Permalink |  | Top
 
TheWraith Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 03:23 PM
Response to Reply #9
11. Oh, I know. That doesn't change the fact that what gets reported is what the public sees.
And the only way to change that is to push back.
Printer Friendly | Permalink |  | Top
 
TheWraith Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 03:53 PM
Response to Original message
13. I've been watching carefully, and noted that this was unrecced a few times.
Four, by my count. I wonder what the hell I did to piss those people off other than be realistic.
Printer Friendly | Permalink |  | Top
 
naaman fletcher Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 05:55 PM
Response to Original message
14. great post! nt
Printer Friendly | Permalink |  | Top
 
tkmorris Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 06:54 PM
Response to Original message
16. Great post
Edited on Wed Dec-15-10 06:57 PM by tkmorris
Credit where it's due. Everything you wrote is true, and it's an important distinction to make.
Printer Friendly | Permalink |  | Top
 
backscatter712 Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 07:31 PM
Response to Original message
17. Good points.
Out of all the cures, this is probably the worst way to do it - the radiation and marrow transplantation procedures for leukemia are risky and miserable enough that there's no way this would work in the real world. IIRC, 1/3 of the people that go through that don't make it.

The hope is that researchers might be able to figure out some things using this case, say how HIV proteins hook up with receptors on immune cells, and be able to come up with some treatments in the future.
Printer Friendly | Permalink |  | Top
 
La Lioness Priyanka Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Dec-15-10 09:40 PM
Response to Original message
18. excellent post
Printer Friendly | Permalink |  | Top
 
DU AdBot (1000+ posts) Click to send private message to this author Click to view 
this author's profile Click to add 
this author to your buddy list Click to add 
this author to your Ignore list Fri Apr 26th 2024, 12:53 AM
Response to Original message
Advertisements [?]
 Top

Home » Discuss » General Discussion Donate to DU

Powered by DCForum+ Version 1.1 Copyright 1997-2002 DCScripts.com
Software has been extensively modified by the DU administrators


Important Notices: By participating on this discussion board, visitors agree to abide by the rules outlined on our Rules page. Messages posted on the Democratic Underground Discussion Forums are the opinions of the individuals who post them, and do not necessarily represent the opinions of Democratic Underground, LLC.

Home  |  Discussion Forums  |  Journals |  Store  |  Donate

About DU  |  Contact Us  |  Privacy Policy

Got a message for Democratic Underground? Click here to send us a message.

© 2001 - 2011 Democratic Underground, LLC