AHA: Caladrius single injection helps heart disease that hits women the hardest

[Bayard]

We tend to think of heart disease and heart disorders to be, in the main, things that affect men more than women, but this is of course not true.

Women not only suffer from heart disease, but they do so differently from men and are in some cases more susceptible to certain cardiovascular (CV) problems. One of these is coronary microvascular dysfunction (CMD).

Caladrius Biosciences and academic researchers have presented new research at the American Heart Association (AHA) that aims to take the fight to this disease in a new way.

Speaking to FierceBiotech from AHA in Philadelphia, Caladrius Chief Medical Officer Douglas Losordo, M.D., explained of the disease: “Many consider CMD to be the exemplar of the underdiagnosis of heart disease in women. CMD was previously referred to as Syndrome X, signifying the mysterious occurrence of cardiac symptoms in the apparent absence of documented heart disease.

“Patients with CMD have the typical symptoms that occur in patients with blockages in the large blood vessels of the heart (those that can be stented or bypassed), but their arteries have no blockages. Unfortunately, before the development of specific tests to diagnose CMD such as measuring coronary flow reserve, these patients were often dismissed. When a diagnosis of CMD is missed, subjects are untreated, and they remain at a high risk of heart attack and/or cardiovascular-related death.”

Caladrius thinks it may have an answer. Its small trial was centered on CLBS16, a CD34 cell that is a naturally occurring preprogrammed microvessel repair cell. “Our mission is to harness the body’s own ability to restore itself after ischemic injuries by isolating these cells from a CMD patient and administering a concentrated dose to the patient to restore the microcirculation,” Losordo said.

https://www.fiercebiotech.com/biotech/aha-caladrius-single-injection-helps-heart-disease-hits-women-hardest?mkt_tok=eyJpIjoiTXpka01USTRaVFF4WmpnNSIsInQiOiJTbDBMXC85NjVzWHk0d01uUGdMRTZGOUpYMlRIUmlyVzNzR2V3bmZwaTZGSTYzVWxpdmlqMmlBdzBURHYwSWNCbHd1MENOTkZHSXpKRWFGM0ZwcEdaSXE5TEFJTlVGclh4RGx3MldkRDlnb0ZXR2VqMjRJM1pBRUt5V0RtZzlMS0kifQ%3D%3D&mrkid=51723015

[Duppers]

1. Wow. That's educational.

I knew nothing about this. I had a cousin who suffered with frequent angina who died. Bet her doctors missed this diagnosis.

Thanks for this info - it could save lives!