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Wed May 6, 2020, 09:27 PM

Using human brain tissue in lab dishes, researchers show herpes link to Alzheimer's

https://www.statnews.com/2020/05/06/researchers-show-herpes-link-to-alzheimers/

A small 3D version of the human brain develops key features of Alzheimer’s disease when it is infected with a virus that causes cold sores, scientists reported on Wednesday, adding to the evidence that this most common form of dementia can be caused by a common microbe.

The new research, published in Science Advances, is the first to directly show in a lab model (rather than through circumstantial evidence from human studies) that the herpes simplex virus HSV-1 might cause Alzheimer’s: Human brain-like tissue infected with the virus became riddled with amyloid plaque-like formations — the hallmark of Alzheimer’s. It also developed neuroinflammation and became less effective at conducting electrical signals, all of which happen in Alzheimer’s disease.

“This is a very important paper,” said Dev Devanand, chief of geriatric psychiatry at Columbia University College of Physicians and Surgeons, who was not involved in the study and is leading a clinical trial to see whether antiviral drugs can treat mild Alzheimer’s. The HSV-1 findings “support the role of viruses in Alzheimer’s disease."

More at link.

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Reply Using human brain tissue in lab dishes, researchers show herpes link to Alzheimer's (Original post)
SheltieLover May 2020 OP
LisaL May 2020 #1
BigmanPigman May 2020 #2
marybourg May 2020 #4
BigmanPigman May 2020 #5
marybourg May 2020 #6
marybourg May 2020 #3
yardwork May 2020 #7
qazplm135 May 2020 #8
SheltieLover May 2020 #9
Post removed Apr 11 #16
tavernier May 2020 #10
SheltieLover May 2020 #11
SharonAnn May 2020 #12
SheltieLover May 2020 #13
Staph May 2020 #14
SheltieLover May 2020 #15
littlemissmartypants Apr 11 #17

Response to SheltieLover (Original post)

Wed May 6, 2020, 09:28 PM

1. Well, most of us are doomed then.

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Response to SheltieLover (Original post)

Wed May 6, 2020, 09:30 PM

2. Uh oh...all the females in my family have had a history of cold sores.

I heard that a mother can give it to a newborn just by kissing it.

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Response to BigmanPigman (Reply #2)

Wed May 6, 2020, 09:36 PM

4. Did any eventually develop Alzheimer's?

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Response to marybourg (Reply #4)

Wed May 6, 2020, 09:40 PM

5. My grandmother got dementia at the age of 98

and she lived to be almost 104. I don't think it was classic Alzheimer's though.

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Response to BigmanPigman (Reply #5)

Wed May 6, 2020, 09:53 PM

6. Wow. That's pretty good!

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Response to SheltieLover (Original post)

Wed May 6, 2020, 09:36 PM

3. My father was very prone to cold sores, but, as of date of death

at 69, had no sign of cognitive decline.

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Response to SheltieLover (Original post)

Wed May 6, 2020, 09:55 PM

7. Damn viruses. /nt

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Response to SheltieLover (Original post)

Wed May 6, 2020, 10:31 PM

8. is it me

or does it appear there are multiple links to Alzheimer's?

Feels like there is some underlying common denominator that they are missing, or that there are multiple pathways to creating Alzheimer's.

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Response to SheltieLover (Original post)

Wed May 6, 2020, 10:40 PM

9. Here is link to Aussie Laser tx info

https://www.australianlaser.com.au/cold-sores/

I'd read about this 20 years ago with very favorable reports.

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Response to SheltieLover (Reply #9)


Response to SheltieLover (Original post)

Wed May 6, 2020, 10:47 PM

10. I had cold sores in my thirties but I froze them with ice

and eventually they never came back. I’d keep ice on my lip for hours off and on but it always did the trick. Very uncomfortable but I think it killed the bugger.

I’m 73 and no Alzheimer’s.

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Response to tavernier (Reply #10)

Wed May 6, 2020, 10:50 PM

11. Great idea!

Glad it worked for you!

I lived in FL, briefly, some years ago & used to get a cold sore on my lip after being near ocean. I moved & they stopped appearing. I always thought this was strange.

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Response to SheltieLover (Reply #11)

Wed May 6, 2020, 11:29 PM

12. They show up with sunburn, even a mild overdose of sun.

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Response to SharonAnn (Reply #12)

Wed May 6, 2020, 11:43 PM

13. Thank you

Does the sun activate a dormant virus, then?

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Response to SheltieLover (Original post)

Wed May 6, 2020, 11:46 PM

14. My mother, sisters and I have suffered from cold sores our entire lives.

Mine seem to be aggravated by stress and too much sun.

Mom is 96 and sharp as a tack. Right now, she's reading a book and watching The Eleventh Hour on MSNBC. She hates Trump!


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Response to Staph (Reply #14)

Wed May 6, 2020, 11:52 PM

15. See #9 avove for

Link to Aussie Laser treatment info. 👍

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