I don't see how they can determine how effective a vaccine is in such a short period of time,

[still_one]

Wouldn't the participants exposure to the virus take time, unless they are intentionally exposed to the virus?

[SheltieLover]

1. They can't

[KPN]

14. Damn. The two words that sprang to my mind immediately.

they can’t!

[SheltieLover]

15. Yup

[rampartc]

2. the "warp speed" vaccine has little to do with safety or effectiveness

but it will be out by election day.

[still_one]

6. The safety aspect I have less concern about than the effectiveness of it.

I think it would be a disaster if a vaccine was released that was not very effective. It would give people a false sense of security, put millions at risk because many would not be using masking and social distancing, assuming the vaccine protects them more than it does

[Maeve]

3. There ya go, talking science!

Neither 'effective' nor 'safe' can be determined in the short-term

[MakeAmericaLoveAgain]

4. President "Golden Nuts" will Distort the truth on a Vaccine.

Vaccine = Votes even though Republicans refuse to wear masks or take vaccines.

[Blues Heron]

5. They've come a long way since the 70s swine flu debacle

the polio nightmare was 70 years ago, the swine flu thing was almost 50 years ago, surely with our biotech machines we've made progress and the stuff won't be likely to make your arm fall off or give you Covid 19.

[still_one]

8. I am not worried about the safety issues. The vaccine is not a live vaccine, so I am not worried

about it giving one SARS CO V2

What is the concern is how effective it is, and releasing a vaccine which isn't particularly effective, would be a disaster, and determining how protective it is, I don't think you can reliably determine how effective it is in a short period of time, unless of course they intentionally expose the participants to the virus

[Blues Heron]

11. they can measure the antibody response for one

they're not just flying blind here the way they were back in the day. There has been biotech progress on that front.

[still_one]

17. They have seen the antibody response already from the phase 1 and phase 2. It is the

phase 3 that will help determine its safety and how effective it really is through double blind studies. It has significantly more participants than a phase 1 or phase 2, but it takes time to determine that effectiveness unless they intentionally expose the volunteers to the virus

If phase three shows safety and efficacy, it will then be released.

Phase 4 will determine the actual long term effects, but that is after it has been released

[KPN]

18. True. But personally, I'm worried about side effects having had personal

experience with something called Guillaine-Barre Syndrome and family history of pulmonary fibrosis (7 of my Mom’s 8 siblings died of it).

[NRaleighLiberal]

7. science is being swallowed by politics. we all pay.

[beachbumbob]

9. no evidence of effectiveness ot safety is possible in the rush by trump for

a COVID vaccine to be released before Nov 3rd. Will have to be an idiot to take it

[Blues Heron]

12. Evidence of both is very possible actually

thank god we have brave volunteers who know and trust our health experts.

[Aristus]

16. For influenza, an effective antibody response can be evaluated in around two weeks.

But I don't think anyone knows yet what the effective antibody response period will be for COVID-19.

There is still so much we don't know about the virus...

[DetroitLegalBeagle]

10. Side effects are the concern, effectiveness less so

From my limited understanding on this, the effectiveness of the vaccine could be seen from the limited human testing that's going on, particularly with how easily spread COVID appears to be. Human challenge trials could prove it as well, but I don't think they are doing that since its ethically and legally a gray area. The bigger concern, that cannot be sped up, is side effects and long term effects. Side effects may not be seen until widespread use since a limited human trial may not represent the wide range of medical conditions and genetics that the population has. And long term issues with the vaccine is basically impossible since those won't be seen until months to years down the line.

[spanone]

13. it's trump world. the only thing that matters is that he can say 'we have a vaccine'

life and death are not considerations

[ecstatic]

19. Of course not, it's just another con.

trump's CDC and FDA are fully compromised or should I say, "deconstructed."

[Yavin4]

20. Didn't the Zombie apocalypse happen because of a bad vaccine?

Happened in one of those movies.

[Demsrule86]

21. They can't. The polio vaccine gave kids polio in its first vaccine iteration. My mother was so

traumatized by this that she refused to give my older sister the measles vaccine...no child in my family received it. My sister caught old fashioned measles and the doctor convinced my Mom to give it to everyone. By then it was safe. So the rest of us had a milder case of measles...still very ill though. My sister spent two months in a dark room where they fought to save her eyesight. Everyone was quarantined. There was a sign on our door. And over the years, there have been ' hot spots' for vaccines...could be the manufacturing was subpar. My own daughters both reacted to the Pertussis vaccine and were hospitalized. No doctor has ever been willing to try again. My children received all their vaccines...but the girls did not get the pertussis booster. I did space out the vaccines ...refused to do them all at once. And that seemed to work better.

[still_one]

22. That was NOT the Salk vaccine The polio vaccine you are referring to was a live vaccine

The oral sabin polio vaccine, which I do not believe is still used here in the U.S., can give someone polio, including someone who cares for the child

The measles vaccine is a live vaccine, but as long as someone is not immuno-compromised, or certain other conditions, it is not only safe, but very effective.

The old pertussis vaccine was not that effective, and for did have side-effects. some very severe. The acellular pertussis vaccine is not only much more effective, but also much safer

For me the general rule is to avoid live vaccines if possible, unless the risk is significant

As I alluded to above, those with certain conditions or immuno-compromised should avoid live vaccines, at least that is the usual recommendations