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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsSingle dose of psilocybin spurs growth of neural connections lost in depression
The psychedelic drug psilocybin, a naturally occurring compound found in some mushrooms, has been studied as a potential treatment for depression for years. But exactly how it works in the brain and how long beneficial results might last is still unclear.
In a new study, Yale researchers show that a single dose of psilocybin given to mice prompted an immediate and long-lasting increase in connections between neurons. The findings are published July 5 in the journal Neuron.
"We not only saw a 10% increase in the number of neuronal connections, but also they were on average about 10% larger, so the connections were stronger as well," said Yale's Alex Kwan, associate professor of psychiatry and of neuroscience and senior author of the paper.
Previous laboratory experiments had shown promise that psilocybin, as well as the anesthetic ketamine, can decrease depression. The new Yale research found that these compounds increase the density of dendritic spines, small protrusions found on nerve cells which aid in the transmission of information between neurons. Chronic stress and depression are known to reduce the number of these neuronal connections.
https://www.sciencedaily.com/releases/2021/07/210705113923.htm

BComplex
(9,237 posts)It would seem like those dendritic spines might be part of what happens to the brain of Alzheimer's patients?
Richard D
(9,568 posts). . . that is worthy of further research.
peggysue2
(11,602 posts)Having had family members suffer and ultimately die with Alzheimer's, my ears always perk whenever a new drug or treatment is suggested, directly or indirectly. Curiously, my father and sister both demonstrated prolonged periods of chronic stress and depression. They shared those symptoms much earlier than the classic, observable Alzheimer's problems.
Might there be a connection? Don't know.
Interesting nonetheless.
LiberalLoner
(10,553 posts)Ellipsis
(9,201 posts)ProfessorGAC
(71,515 posts)Could be I suppose, but many MS patients (me included) don't have lesions in the higher brain areas.
I have a couple on the brain stem, one on the LGN (probably why I'm left eye blind), and a few tiny ones on the cervical spine.
Of course, if this reconnection works on any & all parts of the brain, i might be useful. But, I had thought psychoactive substances worked on higher brain function, but could be incorrect.
So, not sure this would do much for me. But, might help others.
Goddessartist
(2,067 posts)And she swears by it. We get them locally sourced.
LiberalLoner
(10,553 posts)Like the idea of my brain being healed. I wonder if microdoses that didnt get a person high would work?
panader0
(25,816 posts)I'm old now and have lost my connections---.
Aldous Huxley's "The Doors of Perception" deals with the benefits of mescaline.
I've come to the conclusion that all psychedelics benefit the brain.
Hekate
(96,091 posts)
Captain Zero
(7,670 posts)Nt
nvme
(871 posts)Plaque build up is thought to be one of the mechanisms in Alzheimer's. Adding more dendrites does not necessarily help. There is a new drug that is out there; it deals with the plaques but there is significant controversy surrounding it.
flying_wahini
(8,045 posts)My Father in Law suffered for decades with depression and may
have actually been up for trying it. He was 93 when he passed and was just tormented
So badly.
triron
(22,240 posts)eShirl
(19,031 posts)kind of a rhetorical question, and kind of not
Saoirse9
(3,838 posts)I am very (situationally) depressed and don't want to take anti-depressants because of the side effects.
azureblue
(2,350 posts)then you find some fresh cow poop. Then you look to see if there are mushrooms growing out of it. if you break the cap and the cap turns blue, congratulations!
I once was lucky to live across the street from a cow pasture.......
Captain Zero
(7,670 posts)Saoirse9
(3,838 posts)and a horse and two goats. But I confess I have no talent for searching through poop. And my neighbors would freak out if I did.
elevator
(415 posts)Generally they appear after a rain and I picked them 50-60 times in grad school at UGA. If you pinch the stem it will actually turn blue after a few seconds. Never saw a cap turn blue, but guess it could.
H2O Man
(76,156 posts)are uncomfortable with plants that make them think differently, these mushrooms are illegal. Thus, one must locate them in other ways. While some can accurately identify this type of mushroom in a pasture after a morning rain, most cannot. Hence, for safety's sake, they access the black market.
For those who suffer with depression -- especially with co-morbid anxiety -- the type that goes by the name "golden prophets" are strongly recommended. They are associated with a relatively mild high when taken in small doses.
Saoirse9
(3,838 posts)H2O Man
(76,156 posts)where it is legal to buy the spores on the internet, though not to grow them. Thus, if a person were to buy a small quantity of spores, and is familiar with either one of the books or an internet source on growing them, it can provide a personal supply with relatively low legal risks.
elevator
(415 posts)I don't know if it's legal to order the dried shrooms on-line...might be worth checking.
Lochloosa
(16,485 posts)active Psilocybin. They are not easy to grow and require a commitment.
But it's worth it.
Ligyron
(7,929 posts)Grows on cow or horse poop and is very easy to identify once youve seen it.
We could have given the Pranksters and their Acid Tests a run for their money with our sroom parties back in the early 70s.
They almost always had a big pot of sroom juice brewing at the free concerts Tom Pettys bandmate threw on his familys property east of Gainesville. Saw a lot of great southern rock bands there before they became famous.
I wonder if anybody here attended some of these unforgettable events and can help me remember some of the crazy stuff that happened?
H2O Man
(76,156 posts)who used to live in Texas, and was thus able to access massive quantities of them. If my memory serves me correctly, we used them exclusively for recreational purposes back then. Them and other plants. Fiifty years later, we are all old and inhabiting worn-out bags of bones. A wild night these days is being able to watch tv relatively pain free. Why didn't anyone warn us of what was to come? I mean, other than those who did warn us?
I remember attending a three day graduation festival, complete with great live music, in an old farm pasture long ago. I went to take a piss, and a guy near me was puking, and saying, "Look! I'm puking a rainbow!" I asked what he was on? Peyote! Next question: You got any more?
Ligyron
(7,929 posts)There was a spirit of exploration and mind expansion that had noble intentions at least. I know it was hard for me, and others I know, to see the world in the same way afterward. It was like you were now one of the Enlightened ones. as in, "Are you experienced"?
It was when the hard drugs came in that things went south.
i have tried small doses of golden teachers and report help with
depression , and death anxiety .
at 74 and still a hippy I rejoice that this research is underway again
Hallelujah
check the dirty fu&ing hippies were right for a fun overview rant
peace up
elevator
(415 posts)we had all we could handle in the farming areas around Athens. I can remember picking several grocery bags full in a couple hours. Once an old farmer caught my girlfriend and i picking some in his field. He asked what we did with them and we said we put them in salads or on steaks etc. He asked us to give him some. Would have liked to have been a fly on the wall at dinner that evening.
Yep, we would boil the shrooms in water and make a tea. Then we would add grape koolaide to make it palatable. Usually a six ounce plastic cup would get you off for several hours. Depending on the strength you could trip, or just feel incredibly wonderful for hours. We used to party around a lake on a farm as well with 40-50 folks just going wild dancing in the moonlight. And no hangover....you just came down and maybe felt a bit drained. Always felt great for weeks after doing them.
Ligyron
(7,929 posts)Probably some of the best times I ever had happened back then.
Actually, scratch probably.
Crunchy Frog
(27,288 posts)At the current rate of progress, I'll be dead before they come up with an effective, commercially available, treatment for my kind of depression/anxiety disorder.
H2O Man
(76,156 posts)modern medications benefit many people with chronic depression, I do hope that doctors will be able to prescribe mushrooms soon. In the proper doses, they seem to get good results. Younger medical professionals seem to have more open minds regarding such things. Although I'm long retired, I know that some mental health professionals are finding that mushrooms have value in treating many veterans with severe PTSD.
Danascot
(4,954 posts)it is legal to buy and possess the spores, available on the internet for research purposes. The spores can be propagated and can result in numerous mushrooms. There are many how-to instructions for growing them, also available on the internet.
Javaman
(63,334 posts)I just finished reading it. I always joked about takingLSD when I turn 80, but after reading his book, Im seriously looking into mushrooms instead for my general anxiety disorder. And taking them now instead of waiting
Its about setting and who is your guide.
Saoirse9
(3,838 posts)Richard D
(9,568 posts). . . every adult should have access to. Hopefully, the Decriminalize Nature movement will continue to have success.
superpatriotman
(6,625 posts)nt
SergeStorms
(19,392 posts)why I'm happy a great deal of the time then. It's been many decades, mind you, but that used to be a weekly sacrament of ours.
japple
(10,432 posts)pastures all around. It was truly a magical experience. I probably wouldn't have the guts to go out and look for them now, but back then...it was all part of the scene.
SergeStorms
(19,392 posts)stick them in a pot, boil them up into tea, take a trip and never leave the farm.
IbogaProject
(4,048 posts)They released a study a year or two ago, where they studied inflammation w Alzheimer's and did a 2 or 3 week trial on those patients w micro doses of LSD, they did 5 micrograms and 10 & 20 micrograms w a fourth group as a control. In as little as 5 or 7 doses spaced out every 3rd day there was a dose dependent positive result of less inflammation in the treated groups.
Different substance and different effect, but both show the healing properties of entheogens (replacement term for psychedelic). They were banned mostly because the increased compassion, improved mood afterwards, reduced things like alcoholism and the thing the powers that be hated the most they reduced the willingness to fight and be in the military.
Chainfire
(17,757 posts)Timewas
(2,376 posts)Somewhat legal
https://filtermag.org/oregon-legal-psilocybin-therapy/
calimary
(85,162 posts)My wonderful Oregon!
Hortensis
(58,785 posts)H2O Man
(76,156 posts)I think that they should be recognized as a safe form of treatment for depression.
Hortensis
(58,785 posts)the idea that someday a treatment might achieve a lot more, longer, than taking mood stabilizing pills each day can do.
"It was the best of times, it was the worst of times," just popped to mind. Had to look up the rest of it.
"...it was the age of wisdom, it was the age of foolishness, it was the epoch of belief, it was the epoch of incredulity, it was the season of light, it was the season of darkness, it was the spring of hope, it was the winter of despair.
H2O Man
(76,156 posts)I used to assist a man who practiced his people's traditional medical practices. This included gathering various plants at different times of years .....we'd venture into fields, the woods, and especially creek beds. I have great respect for modern medical advances, no doubt, but recognize that there are plants that offer effect relief for many conditions.
quaint
(3,718 posts)I have seen the fear of death leave friends as they peacefully waited.
SheltieLover
(62,414 posts)Great news!
FakeNoose
(36,543 posts)This is something I would leave to the experts. God only knows that a lot of wild fungi - mushrooms and toadstools - are fatal when ingested by humans. I would never want to take a chance on "maybe" getting the right one.
I_UndergroundPanther
(13,004 posts)I have been on every psych drug..it's good for PTSD too .
Loki Liesmith
(4,602 posts)This looks like a post hoc ergo propter hoc argument.
Ilsa
(62,488 posts)who have terminal cancer, to help with anxiety and depression.
Duppers
(28,280 posts)Thanks for posting this!
smirkymonkey
(63,221 posts)I think humanity is in desperate need of it. If we can find a naturally occuring, easily produced substance that can help treat depression and debilitating anxiety, it would be such a gift to the world.
Not only that, but it could possibly help with treating addictions, especially the opioid crisis and even be used to treat those with terminal illness in hospice situations to help them pass without trauma or emotional anguish.
And maybe, just maybe, it could be experimented with on brainwashed MAGAts to make them less hateful and violent! I'm serious here!
There is so much potential!
burrowowl
(18,118 posts)struggle4progress
(121,341 posts)and you've just had some kind of mushroom and your mind is moving low
go ask Alice: I think she'll know
When logic and proportion have fallen sloppy dead
and the White Knight is talking backwards and the Red Queen's off with her head
remember what the Dormouse said: feed your head
Wicked Blue
(7,455 posts)Especially during dinner, when the kids lived at home and were acting up at the table.
"No, Mom , PLEASE! ANYTHING but that!"
Blue Owl
(55,229 posts)BobTheSubgenius
(11,861 posts)IronLionZion
(47,502 posts)it should be on the ballot in some states for medicinal or recreational use. Several research universities like Johns Hopkins have been studying it for mental health treatment for a while. They've also used it to treat anxiety, PTSD, and other issues.
malthaussen
(17,920 posts)-- Mal
Roisin Ni Fiachra
(2,574 posts)Massive doses, back in the day. Profound mystical experiences.
panader0
(25,816 posts)I built him a large building out of block and one small part was a hay steaming room.
He would put a bale or two of hay in this sealed room and had it rigged to heat the hay to
sterility with steam.
Once clean, he transferred the hay to several bins and sprinkled them with spores.
The thing he liked about growing 'shrooms was that they appeared overnight and had no
lengthy growing period, like pot.
He was a mushroom master, traveling to the forests in Northern Az when it rained and picking
shittakes. Then he drove to the high class restaurants in Phoenix and Tucson and sold them to the chefs.
I just saw him yesterday after all these years.....