Persistent symptoms in adult patients one year after COVID-19: a prospective cohort study

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Dr. Tom Frieden
@DrTomFrieden
·
Jul 7, 2021
Striking. 12 months after their symptoms started, only 23% of Covid patients in a new study from Germany were completely free of symptoms.

Dr. Tom Frieden
@DrTomFrieden
Long Covid symptoms, including fatigue, shortness of breath, brain fog, and sleeping problems can last at least a year for some patients—and cause major disruption to their lives.

Persistent symptoms in adult patients one year after COVID-19: a prospective cohort study
AbstractBackground. Long COVID is defined as the persistence of symptoms beyond 3 months after SARS-CoV-2 infection. To better understand the long-term course a
academic.oup.com
1:30 PM · Jul 7, 2021

Abstract

Background

Long COVID is defined as the persistence of symptoms beyond 3 months after SARS-CoV-2 infection. To better understand the long-term course and etiology of symptoms we analyzed a cohort of COVID-19 patients prospectively.

Methods

Patients were included at 5 months after acute COVID-19 in this prospective, non-interventional follow-up study. Patients followed until 12 months after COVID-19 symptom onset (n=96, 32.3% hospitalised, 55.2% females) were included in this analysis of symptoms, quality of life (based on a SF-12 survey), laboratory parameters including antinuclear antibodies (ANA), and SARS-CoV-2 antibody levels.

Results

At month 12, only 22.9% of patients were completely free of symptoms and the most frequent symptoms were reduced exercise capacity (56.3%), fatigue (53.1%), dyspnoea (37.5%), concentration problems (39.6%), problems finding words (32.3%), and sleeping problems (26.0%). Females showed significantly more neurocognitive symptoms than males.

ANA titres were ≥1:160 in 43.6% of patients at 12 months post COVID-19 symptom onset, and neurocognitive symptom frequency was significantly higher in the group with an ANA titre ≥1:160 compared to

[Ms. Toad]

1. One of the reasons I keep pushing back on the stats that focus on death as the dreaded outcome

and suggest that because, in some stats, the risk of death appears miniscule that COVID is no big deal for vaccinated people.

We've got DU members with Long COVID, who were infected months after full vaccination.

Striking. 12 months after their symptoms started, only 23% of Covid patients in a new study from Germany were completely free of symptoms.

. . .

Compared to patients without symptoms, patients with at least one long COVID symptom at 12 months did not differ significantly with respect to their SARS-CoV-2-antibody levels, but had a significantly reduced physical and mental life quality compared to patients without symptoms.

Long COVID is only one if the significant non-death consequences of COVID.

[marybourg]

2. Curious as to what the ANA titre means. Lupus?