What is the history of Ivermectin being suggested as a Covid drug?

[PA_jen]

I will be honest the first I heard of this was last week and thru the weekend. How and when did all this start. More importantly who is profiting from this?

[DeeDeeNY]

1. Where else but Fox

https://amp.cnn.com/cnn/2021/08/23/media/right-wing-media-ivermectin/index.html

[Trueblue1968]

14. fox is killing off their base.

[OnDoutside]

2. All I have heard is that it's actually off patent and really cheap to

manufacture, however there haven't been enough human studies into it yet.

[Maru Kitteh]

4. Human studies for what?

[DeeDeeNY]

9. People are getting poisoned from it

https://www.marketwatch.com/amp/story/you-are-not-a-horse-you-are-not-a-cow-fda-urges-people-to-stop-taking-drug-for-covid-thats-meant-to-deworm-livestock-11629750512

[Maru Kitteh]

19. Yeah that was kinda my point. As in, looks like human studies

are being done by remarkably stupid humans as we speak.

[OnDoutside]

23. No, it's in the same way Pfizer and Moderna etc had to do trials and

peer reviewed studies on their vaccines before they were approved for use on humans.

[Klaralven]

12. Since the summer of '20 there have been numerous studies. It has been shown to be ineffective.

The few studies with positive results are typically with small sample sizes and likely statistical flukes. If you run enough small studies, some will turn up positive just by chance. Meta-analyses that combine the studies do not show an effect.

[boston bean]

3. I heard it from an acquaintance months ago.

She was saying they were hiding a cure to help big pharma. And the vaccines were poison.

She is batshit. And I would have never thought of her to be so nuts. She has really been foxified and qanoned.

[mopinko]

5. i believe there were some demographics that were not being hit as hard.

there are a couple countries where it is a common med, and they had low covid numbers.
that was fairly early on. i saw a small study out of australia that had promising numbers.

that's about it tho.

[Eugene]

6. Nature covers a withdrawn preprint paper with echoes of hydroxychloroquine.

Plagiarism, cherry picking, etc.

Flawed ivermectin preprint highlights challenges of COVID drug studies

The paper’s withdrawal is not the first scandal to dog studies of ivermectin and COVID-19. Hill thinks many of the other ivermectin trial papers that he has scanned are likely to be flawed or statistically biased. Many rely on small sample sizes or were not randomized or well controlled, he says. And in 2020, an observational study of the drug was withdrawn after scientists raised concerns about it and a few other papers using data by the company Surgisphere that investigated a range of repurposed drugs against COVID-19. “We’ve seen a pattern of people releasing information that’s not reliable,” says Hill. “It’s hard enough to do work on COVID and treatment without people distorting databases.”

https://www.nature.com/articles/d41586-021-02081-w

[PA_jen]

13. Thank you

[milestogo]

7. Trump mentioned it last year, and people started taking it in African countries.

Its really dangerous for a non-medical person to weigh in on these things.

[treestar]

22. Reminds me of Lawrence O'Donnell

When trump recommended the other drug:

“Donald trump is not a doctor ! Donald Trump is not a medical expert! Do not take medical advice from Donald Trump!”

Dumb magats!

[AZProgressive]

8. I saw it suggested on another website

I haven’t been back soon after that drug was suggested. I call it a tree website now.

[Maru Kitteh]

20. Not surprised at all those shit-wits are a a twitter for sheep dip. nt

[cadoman]

10. there is zero science supporting use of ivermectin -- AVOID and do NOT discuss

https://www.fda.gov/consumers/consumer-updates/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19

Merck created it and even they say not to take it!

https://www.merck.com/news/merck-statement-on-ivermectin-use-during-the-covid-19-pandemic/

[PA_jen]

15. I just wanted to understand because my anti-vax/covid-hoax sister will bring this up

sooner or later and I want the info to debunk her. I also believe someone will profit from this mis-information.

[Klaralven]

11. Antiviral Activity of Ivermectin Against SARS-CoV-2: An Old-Fashioned Dog with a New Trick--A Literat

Antiviral Activity of Ivermectin Against SARS-CoV-2: An Old-Fashioned Dog with a New Trick—A Literature Review

Published: 17 August 2020

Abstract

The coronavirus disease 2019 (COVID-19) pandemic is a major global threat. With no effective antiviral drugs, the repurposing of many currently available drugs has been considered. One such drug is ivermectin, an FDA-approved antiparasitic agent that has been shown to exhibit antiviral activity against a broad range of viruses. Recent studies have suggested that ivermectin inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus suggesting its potential for use against COVID-19. This review has summarized the evidence derived from docking and modeling analysis, in vitro and in vivo studies, and results from new investigational drug protocols, as well as clinical trials, if available, which will be effective in supporting the prospective use of ivermectin as an alternative treatment for COVID-19

https://www.mdpi.com/2218-0532/88/3/36

The first study published was probably this one:

Caly, L.; Druce, J.D.; Catton, M.G.; Jans, D.A.; Wagstaff, K.M. The FDA-approved drug ivermectin inhibits
the replication of SARS-CoV-2 in vitro. Antivir. Res. 2020, 178, 104787.

Abstract
Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum anti-viral activity in vitro, is an inhibitor of the causative virus (SARS-CoV-2), with a single addition to Vero-hSLAM cells 2 h post infection with SARS-CoV-2 able to effect ~5000-fold reduction in viral RNA at 48 h. Ivermectin therefore warrants further investigation for possible benefits in humans.

Note that a study conducted on cell cultures in a lab is only the first step, and that in many cases it does not translate into a drug that is effective in humans. In particular, this study has been criticized for using concentrations of ivermectin that are not achievable in human tissue with known safe doses.

[PA_jen]

16. Thank you

[LisaL]

17. Phil Valentine was a fan of ivermectin.

Clearly it didn't do him any good.

[anamnua]

18. I am a practising medic.

The jury is still out on it and the results of large scale trials are eagerly awaited. Therefore the sensible thing is to suspend judgement. It would be great if it turns out to be the real deal -- dirt cheap, off patent, old as the hills (and therefore tried and trusted) and easy to manufacture.
Even in a best case scenario though it is not a substitute for vaccination -- just another important weapon in the arsenal.

[Raine]

21. Im not going to put this down because I really hope it turns out to be

an effective drug that can be used for treatment. 🙏