General Discussion
Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsDoes anyone have any experience with an outfit called science direct?
They have apparently issued an abstract that touts Ivermectin. The link is below, but I hasten to send them traffic.
https://www.sciencedirect.com/science/article/pii/S2052297521000883?fbclid=IwAR0HdDthYR85DSJb7DgNz2y42ZdEXSn607DVBEYDSxrG8MG9kzPKF7EfCOU
Ocelot II
(115,683 posts)NQAS
(10,749 posts)Ocelot II
(115,683 posts)so they can be accessed on line.
NQAS
(10,749 posts)Is that it published peer reviewed papers.
NQAS
(10,749 posts)But skip the headline and read the report. And, if youre like most people, including me, the sciency stuff can be tough to follow.
I read somewhere else a few weeks ago that while ivermectin has human uses, one issue is that of dose. And that its use in don't with COVID is very specific. One factor is that of treatment, not prevention. Its usually not a good idea to treat illnesses and conditions you don't have.
Ocelot II
(115,683 posts)that people are taking doses intended for a thousand-pound animal. Horse de-wormer apparently can also give people terrible diarrhea.
But the MAGAts are not exactly critical readers or thinkers.
Ocelot II
(115,683 posts)over taking a free, safe, painless and effective vaccination that not only won't give them diarrhea but will also keep them out of the hospital on a ventilator. Go figure.
andym
(5,443 posts)some are far more reputable than others.
In this case the journal is "New Microbes and New Infections"
It has an "impact factor" of 1.94 meaning it is not influential (compare to the New England Journal of Medicine at 91.245), possibly less well peer-reviewed and unfortunately there are enough journals these days that almost anything can be published.
As for the content: there are many scientific meta-analyses claiming Ivermectin confers benefit. Unfortunately almost everyone used a preprint that has since been retracted due to analyses showing plagiarism and unreliable data.
You can read about the story here:
https://www.nature.com/articles/d41586-021-02081-w
Flawed ivermectin preprint highlights challenges of COVID drug studies
The studys withdrawal from a preprint platform deals a blow to the anti-parasite drugs chances as a COVID treatment, researchers say.
"Throughout the pandemic, the anti-parasite drug ivermectin has attracted much attention, particularly in Latin America, as a potential way to treat COVID-19. But scientists say that recent, shocking revelations of widespread flaws in the data of a preprint study reporting that the medication greatly reduces COVID-19 deaths dampens ivermectins promise and highlights the challenges of investigating drug efficacy during a pandemic.
I was shocked, as everyone in the scientific community probably were, says Eduardo López-Medina, a paediatrician at the Centre for the Study of Paediatric Infections in Cali, Colombia, who was not involved with the study and who has investigated whether ivermectin can improve COVID-19 symptoms. It was one of the first papers that led everyone to get into the idea ivermectin worked in a clinical-trial setting, he adds.
The paper summarized the results of a clinical trial seeming to show that ivermectin can reduce COVID-19 death rates by more than 90%1 among the largest studies of the drugs ability to treat COVID-19 to date. But on 14 July, after internet sleuths raised concerns about plagiarism and data manipulation, the preprint server Research Square withdrew the paper because of ethical concerns.
....
Before its withdrawal, the paper was viewed more than 150,000 times, cited more than 30 times and included in a number of meta-analyses that collect trial findings into a single, statistically weighted result. In one recent meta-analysis in the American Journal of Therapeutics that found ivermectin greatly reduced COVID-19 deaths4, the Elgazzar paper accounted for 15.5% of the effect."
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Basically that one unreliable paper (which was not even officially published) threw off multiple other studies that try to combine data, including the one you reference.
hlthe2b
(102,236 posts)LisaL
(44,973 posts)It obviously didn't do him any good. It's an anti-parasitic drug, not an anti-viral.
obamanut2012
(26,068 posts)Peer-to-peer, most journals very well respected, used by basically all research libraries, NIH, FDA, NOAA, etc. etc. etc.
TIL from this thread that study was pre-print, too. Oh boy.