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Ocelot II

(115,683 posts)
11. Right, but it doesn't create the articles, just publishes them
Sun Aug 29, 2021, 07:18 PM
Aug 2021

so they can be accessed on line.

NQAS

(10,749 posts)
2. Sounds like it is
Sun Aug 29, 2021, 05:43 PM
Aug 2021
https://www.mvorganizing.org/is-science-direct-reliable/#Is_Science_Direct_reliable

But skip the headline and read the report. And, if you’re like most people, including me, the sciency stuff can be tough to follow.

I read somewhere else a few weeks ago that while ivermectin has human uses, one issue is that of dose. And that it’s use in don't with COVID is very specific. One factor is that of treatment, not prevention. It’s usually not a good idea to treat illnesses and conditions you don't have.

Ocelot II

(115,683 posts)
3. There are other ingredients in the versions used for livestock, not to mention
Sun Aug 29, 2021, 05:47 PM
Aug 2021

that people are taking doses intended for a thousand-pound animal. Horse de-wormer apparently can also give people terrible diarrhea.

Ocelot II

(115,683 posts)
6. I guess they'd rather risk getting uncontrolled projectile diarrhea at Wal-Mart
Sun Aug 29, 2021, 05:52 PM
Aug 2021

over taking a free, safe, painless and effective vaccination that not only won't give them diarrhea but will also keep them out of the hospital on a ventilator. Go figure.

andym

(5,443 posts)
5. Sciencedirect belongs to Elsevier, a major scientific journal publisher. They publish many journals
Sun Aug 29, 2021, 05:51 PM
Aug 2021

some are far more reputable than others.
In this case the journal is "New Microbes and New Infections"

It has an "impact factor" of 1.94 meaning it is not influential (compare to the New England Journal of Medicine at 91.245), possibly less well peer-reviewed and unfortunately there are enough journals these days that almost anything can be published.



As for the content: there are many scientific meta-analyses claiming Ivermectin confers benefit. Unfortunately almost everyone used a preprint that has since been retracted due to analyses showing plagiarism and unreliable data.

You can read about the story here:
https://www.nature.com/articles/d41586-021-02081-w
Flawed ivermectin preprint highlights challenges of COVID drug studies
The study’s withdrawal from a preprint platform deals a blow to the anti-parasite drug’s chances as a COVID treatment, researchers say.

"Throughout the pandemic, the anti-parasite drug ivermectin has attracted much attention, particularly in Latin America, as a potential way to treat COVID-19. But scientists say that recent, shocking revelations of widespread flaws in the data of a preprint study reporting that the medication greatly reduces COVID-19 deaths dampens ivermectin’s promise — and highlights the challenges of investigating drug efficacy during a pandemic.

“I was shocked, as everyone in the scientific community probably were,” says Eduardo López-Medina, a paediatrician at the Centre for the Study of Paediatric Infections in Cali, Colombia, who was not involved with the study and who has investigated whether ivermectin can improve COVID-19 symptoms. “It was one of the first papers that led everyone to get into the idea ivermectin worked” in a clinical-trial setting, he adds.

The paper summarized the results of a clinical trial seeming to show that ivermectin can reduce COVID-19 death rates by more than 90%1 — among the largest studies of the drug’s ability to treat COVID-19 to date. But on 14 July, after internet sleuths raised concerns about plagiarism and data manipulation, the preprint server Research Square withdrew the paper because of “ethical concerns”.
....
Before its withdrawal, the paper was viewed more than 150,000 times, cited more than 30 times and included in a number of meta-analyses that collect trial findings into a single, statistically weighted result. In one recent meta-analysis in the American Journal of Therapeutics that found ivermectin greatly reduced COVID-19 deaths4, the Elgazzar paper accounted for 15.5% of the effect."
----
Basically that one unreliable paper (which was not even officially published) threw off multiple other studies that try to combine data, including the one you reference.


LisaL

(44,973 posts)
7. Phil Valentine was a big fan of Ivermectin.
Sun Aug 29, 2021, 05:54 PM
Aug 2021

It obviously didn't do him any good. It's an anti-parasitic drug, not an anti-viral.

obamanut2012

(26,068 posts)
9. It is a major STEM journal database
Sun Aug 29, 2021, 06:07 PM
Aug 2021

Peer-to-peer, most journals very well respected, used by basically all research libraries, NIH, FDA, NOAA, etc. etc. etc.

TIL from this thread that study was pre-print, too. Oh boy.

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