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OhioChick

(23,218 posts)
Wed Oct 27, 2021, 05:45 AM Oct 2021

Immunocompromised may need a fourth Covid-19 shot, CDC says

Updated 8:23 PM ET, Tue October 26, 2021

People with certain health conditions that make them moderately or severely immunocompromised may get a fourth mRNA Covid-19 shot, according to updated guidelines from the US Centers for Disease Control and Prevention.

The CDC authorized a third dose for certain immunocompromised people 18 and older in August. It said a third dose, rather than a booster -- the CDC makes a distinction between the two -- was necessary because the immunocompromised may not have had a complete immune response from the first two doses.

A study from Johns Hopkins University this summer showed that vaccinated immunocompromised people were 485 times more likely to end up in the hospital or die from Covid-19 compared to most vaccinated people. In small studies, the CDC said, fully vaccinated immunocompromised people accounted for about 44% of the breakthrough cases that required hospitalization. People who are immunocompromised are also more likely to transmit the virus to people who had close contact with them.

The US Food and Drug Administration has also authorized booster shots of all three available vaccines for certain people and that would include the immune compromised, the CDC says.

More: https://www.cnn.com/2021/10/26/health/covid-19-fourth-dose-for-the-immunocompromised/index.html

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Sancho

(9,069 posts)
2. With different strains and declining antibodies...it may end up with annual shots...
Wed Oct 27, 2021, 06:58 AM
Oct 2021


...unless some kind of pill or treatment becomes easily available.

Jersey Devil

(9,874 posts)
4. The reason for the distinction between a 3rd shot and a booster shot is the dosage
Wed Oct 27, 2021, 08:04 AM
Oct 2021

The booster is only half the amount injected for a full dose according to the pharmacist who gave us our boosters for Moderna.

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Scrivener7

(50,949 posts)
10. I was just on the jury for that one. All the Q trolls have the same approach, which does bring
Wed Oct 27, 2021, 08:40 AM
Oct 2021

back memories of the playground in the second grade.

"Oh, yeah? Well you're a stupid-head!!!"

That's basically what they've got.

Weirdly entertaining to see them flail, if you're in the right mood.

Response to Scrivener7 (Reply #10)

BumRushDaShow

(128,916 posts)
13. When I watched CDC's ACIP Moderna/Janssen booster/mix-match meeting last week
Wed Oct 27, 2021, 09:14 AM
Oct 2021

I heard a couple of the members mention that about a 4th dose (and the one who explicitly said it was even surprised herself as she blurted it out ).

I.e., for some severely immuno-compromised people, the vaccine course might need to be a "3-dose regular series" followed by a "4th dose" at some point, which caught my attention.

With Pfizer, all of their doses have been "full" which is why many of the members are trying to get the technical lingo reported correctly when talking "full dose". I.e., you would have a "2-dose primary series" followed by a "3rd (full) dose", making it a "3-dose series".

With Moderna, they actually have "full doses" and "half doses", where you would have a "2-dose primary series" followed by a "half dose booster".

For all intents and purposes, a "1-dose" shot of Janssen (J&J) or a "2-dose series" of either Pfizer or Moderna, would be considered "fully vaccinated", with any additional dosing being optional but not required for that designation of "fully vaccinated" (for travel or entry into facility purposes).

From CDC's meeting last week -

MineralMan

(146,288 posts)
14. That's not surprising. There's also another factor that hasn't
Wed Oct 27, 2021, 09:58 AM
Oct 2021

been discussed much. In the past couple of years, dozens of new "biologic" drugs that suppress the immune system have been introduced by the pharmaceutical companies. The names of those drugs (not the trade names) end with "ib" or "ab". Most are designed to treat autoimmune disorders that involve overactive immune systems, like eczema, Chrohn's disease, rheumatoid arthritis, psoriasis and many others.

You've seen the ads on TV, no doubt. Those "biologics" all work to suppress the immune system to stop it attacking the patients own bodies. They're the hot new drugs on the market.

Problem is that they may well also reduce the effectiveness of vaccines, including COVID-19 vaccines.

I haven't seen much discussion of this, though. But here's a link:

https://www.reuters.com/article/us-health-coronavirus-science/autoimmune-disease-drugs-may-reduce-vaccine-response-antibody-treatments-ineffective-vs-brazil-variant-idUSKBN2BZ2H1

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