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First thought is either the GPU or the screen is failing
If you've done a full anti-virus scan and nothing showed up, it's probably a hardware issue. You've got all the important stuff backed up, so that's good. Since it's a Dell, you're likely looking at either a screen or motherboard replacement, and those can run money. If you check some Dell forums, or maybe Tom's Hardware, you might find someone with a similar situation, and hopefully an easy solution.