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The minimum number of US Senate seats the Democrats will have after 2022 is 50-52 seats.
NH(Hassan-D) depends on whether or not Sununu-R runs. Democrats are favored if Sununu-R does not run.
WI(Barnes-D or Godlewski-D) are favored to win if Johnson-R does not run.
50)GA(Warnock-D) wins the 12/2023 general election runoff against Walker-R or Black-R.
49)PA(Fetterman-D or Lamb-D)
48)AZ(Kelly-D)
47)NV(Cortez Masto-D)
46)CO(Bennet-D)
45)WA(Murray-D)
44)IL(Duckworth-D)
43)OR(Wyden-D)
42)CT(Blumenthal-D)
41)MD(Van Hollen-D)
40)CA(Padilla-D)
39)NY(Schumer-D)
38)HI(Schatz-D)
37)VT(Leahy-D)
36 Democratic held US Senate seats not up for re-election in 2022.