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Many Native American tribes have thinned their numbers (or disappearing) by intermarrying with Europeans.
White supremacists worry about it with mingling of the races.
Some blacks and Jews feel the same way of their cultures not being fully preserved.
France has that worry about 'foreign' words corrupting their language.
At times, royalty has interbred to the point of damage to the progeny.
See the Hapsburg Jaw.
https://www.bing.com/search?q=habsburg+jaw&form=ANNTH1&refig=68c70c0726da4097bdb586aff77f3fe7&pc=U531&pq=hapsburg+jaw&pqlth=12&assgl=12&sgcn=habsburg+jaw&qs=OS&sgtpv=OS&smvpcn=0&swbcn=4&sctcn=0&sc=4-12&sp=1&ghc=0&cvid=68c70c0726da4097bdb586aff77f3fe7&clckatsg=1&hsmssg=0