Her mother was also her uncle, DNA test.

[multigraincracker]

https://www.neatorama.com/2022/11/25/Her-Mother-is-Also-Her-Uncle/

A young girl underwent a DNA test to establish her paternity. The results that came back were so confusing that the science director of the genetic institute in Colombia, Juan Yunis, assumed the sample was contaminated and ordered the test done again. But the results were the same. Some parts of her genome excluded her mother as a parent, while others excluded her assumed father. Further tests found that the child's mother had XY chromosomes in her blood, which indicate a genetic male.

Further research showed that the girl's assumed father was, in fact, her biological father, but only when the mother's DNA was excluded. That drew Yunis' attention to more thoroughly test the mother. The mother had XY chromosomes in her blood and saliva, but her hair and cheek cells had XX chromosomes. Parts of the daughter's genome matched each kind of her mother's mismatched DNA. The daughter had inherited some DNA from her mother which originally belonged to her mother's fraternal twin brother, who was never born. That makes the mother a chimera, the result of an embryo that had absorbed and incorporated cells from a twin who had vanished before anyone knew he had existed. Read the convoluted way this all came about, and how it was found, at Grid. -via Digg

[Joinfortmill]

1. Yikes!

[multigraincracker]

3. The more we know...

The more confused we get.

[NullTuples]

26. The more we know, the smarter we get - if we're willing to learn.

And that's a big part of why Republicans favor education - and a voting public - that is rooted in 1950's high school biology assumptions.

[Siwsan]

2. CSI did an episode about a Chimera.

A rapist whose DNA from a saliva swab excluded him. Everything else pointed to this suspect so Gil Grissom (played by William Petersen) was confused until he saw some striated marks on the man's back. That led him to take DNA from another source, proving the man was the rapist.

I think that's my favorite episode.

[eppur_se_muova]

34. If all else fails, get a sperm sample.

Compare like to like. (I'm assuming they had a forensic sperm sample.)

[LostOne4Ever]

44. I think I remember that episode

I believe wasn’t a chimera so much as he had De La Chapelle syndrome.

[Siwsan]

51. That could be. It was SO long ago.

I checked and I think it was the episode was called 'Bloodlines'. I can remember Gil bringing up, MAYBE, the possibility of a Chimera. It absolutely fascinated me because I'd never heard that term applied to a human.

[CaliforniaPeggy]

4. How fascinating! I read all the links and was mesmerized the whole time.

Thank you for posting this, my dear multigraincracker!

[Maraya1969]

5. I posted a study here once that posited a person that is trans could very well have two sets

of DNA and depending where that DNA was it could make a baby come out with a set of genitals that did not match the DNA of the baby's brain. That would happen when a fraternal twins absorbs another twin of the opposite sex.

[mopinko]

11. i thought only identical twins did that.

i lost a twin that way, and always assumed it was a boy.

[Maraya1969]

12. Not according to that study. And it makes sense since it is harder to carry 2 fetuses to term than

one and if one dies the other will naturally absorb it.

[mopinko]

13. i guess i just assumed.

dumb. but assumed it required a single placenta. i guess that makes it easier, but i'm sure there's overlap. now i'm curious about how it works, exactly.

[Rebl2]

17. Exactly

I have read this before somewhere. I wish I knew where, but it’s been quite a while ago.

[MiHale]

6. The "point back" article at Neatorama...

could a really confuse some (not pointing to any specific group) not so open minded among us. My brother was a research scientist specializing in diabetes and his wife still works in stem cell research last family get together we discussed this very subject briefly.
Bro mentioned that if only more people could understand even a little…but his IQ blinds him to others comprehension.

g’d morn MGC.

[Ferrets are Cool]

7. Wow, just WOW!!

[GPV]

8. Men with klinefelters are xxy. Wonder how their tests read?

[niyad]

9. KNR and bookmarking. For later.

[halfulglas]

10. You would think that evidence like this would move those bigoted fools to change their thinking.

There are natural variations in human sexuality that prove there are more than 2 sexes. It isn't "evil" or "unnatural" to be different, but they take a line from the bible and interpret it the way want it to be as proof.

[markodochartaigh]

21. Generally

bigoted fools are not bigoted because of their reliance on facts, they are bigoted because of their reliance on beliefs. They may use particular facts to reinforce their beliefs but they may also ignore facts which contradict their beliefs. Because their bias comes from beliefs and not from facts, exposing them to more facts rarely changes their bias.

[AdamGG]

50. Even without the evidence, they could emulate their supposed role model

and just think 'live and let live' and not be judgemental about it.

[ananda]

14. Very interesting and informative.

That explains so much.

[paleotn]

15. Genetics are messy. Chimerism. Rare, but it happens.

Biology just won't follow our foolish notions of what's normal and what's not. It refuses to be put into nice, neat, little boxes.

A similar case....

https://www.livescience.com/61890-what-is-chimerism-fused-twin.html

Answer me this, Christian forced birthers, where is her sib's "soul?" Since "life" begins at conception, does she get to vote twice? After all, by their own definition, she is two people in one. This is what happens when religion intrudes on reality and doesn't stick to it's lane in fantasy world.

[keithbvadu2]

16. Bone marrow transplant may change dna?

Bone marrow transplant may change dna?

https://www.google.com/search?q=bone+marrow+transplant+change+dna&rlz=1C1AWUC_enUS1014US1023&oq=bone+marrow+transplant+change+dna&aqs=chrome..69i57j0i22i30l9.39969j1j15&sourceid=chrome&ie=UTF-8

[GB_RN]

18. Yup

A cheek swab would show your own DNA. However, a blood draw would show the DNA from whoever donated the marrow, assuming that the donation is allogenic - IOW, not a self (or autologous) donation.

[LeftInTX]

19. Bone marrow transplant was my first thought

[NullTuples]

42. As does getting pregnant.

It's been pretty well documented that women* who have carried a male* fetus have a good chance of his cells passing through the placenta and "colonizing" (the researchers' word) locations in her body.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633676/


* for the sake of a simple example I'm assuming they're all cisgender, with typical XX or XY karyotypes.

[imavoter]

43. an acquaintance had a bone marrow transplant

and his blood type is in the process of changing.
When he needs blood transfusion he gets
O negative now, so there won't be issues.

[Gruenemann]

20. Which bathroom do Republicans want her to use????

Rhetorical question, of course.

[stopdiggin]

22. fascinating. thanks so much for posting.

I was actually (slightly) familiar with the concept of chimera. (I think maybe in relation to 'extreme' tortie patterning in domestic cats?) And, while still comparatively rare (among humans, probably less so in other life forms) - it does tend to puncture some of the smug certainty of the mechanical 'A+B' thinking.

https://cattitudedaily.com/what-is-a-chimera-cat/

[DBoon]

23. some cats are natural chimeras

https://kritterkommunity.com/calico-cats-vs-chimera-cats-are-they-the-same/

[catchnrelease]

28. It can also be found in birds

Cardinals with male and female genetics...



[link:|

[Sky Jewels]

24. The Dwight Schrute Strategy

https://images.app.goo.gl/vCVXcXgvZgPooBZm9

[NullTuples]

25. Not unheard of, but nobody looked prior to maybe a decade ago.

There have been several published papers on women who successfully carry a pregnancy to term and turn out to have XY chromosomes.

One was assigned female at birth, went through a typical girl -> woman childhood and puberty, got married, had a child and then was found to have XY chromosomes. But the really interesting part is that her daughter also has XY chromosomes.

Before maybe 8-10 years ago, chromosome testing was expensive. So if someone gave birth, it was simply assumed a karyotype test would come back XX.
But since then, it's become much, much cheaper so more testing is done. And it turns out that it's unusual, but now well documented that a woman can have XY chromosomes.

Naturally, these last ten years or so is also the time period in which Republicans and other conservatives have tried to appropriate concepts such as "follow the science" without actually doing so. Because the science is so very inconvenient for many of their now-bedrock assummptions.

[Rocknation]

27. That's happened in the U.S., too (the mother was charged with fraud)

Last edited Fri Dec 2, 2022, 12:21 PM - Edit history (3)

The Case of Lydia Fairchild and Her Chimerism

In 2002, after applying for government assistance in the state of Washington, Lydia Fairchild was told that her two children were not a genetic match with her and that therefore, biologically, she could not be their mother. Researchers later determined that the genetic mismatch was due to chimerism, a condition in which two genetically distinct cell lines are present in one body. The state accused Fairchild of fraud and filed a lawsuit against her.

Following evidence from another case of chimerism documented in The New England Journal of Medicine...Fairchild was able to secure legal counsel and establish evidence of her biological maternity. A cervical swab eventually revealed Fairchild’s second distinct cell line, showing that she had not genetically matched her children because she was a chimera.

Fairchild’s case was one of the first public accounts of chimerism and has been used as an example in subsequent discussions about the validity and reliability of DNA evidence in legal proceedings within the United States.

Rocknation

[Hekate]

29. The study of chimeras is fascinating

[Martin68]

30. Wow! That's an episode of Las Vegas CSI I missed.

[multigraincracker]

31. God created a man and a woman...

The Lord works in mysterious ways.

[NullTuples]

40. I've always found that part of Genesis fascinating, since the assumption is...

...that scribes' hands were guided by God & therefore the text is pretty close to infallible.

Over and over it could've been changed to the binary, "He made them man OR woman" (emphasis mine). But instead it's "He made them man AND woman" overtly recognizing that human sex dimorphic traits over populations chart out as two highly overlapping bell curves.

[keithbvadu2]

45. Eve was the first transgender. Originally 100% male.

For the Bible folks:::

Eve was the first transgender. Originally 100% male.

God was OK with it.

[NullTuples]

49. Consider this:

For Mary to conceive & bear a child without sperm, it had to be parthenogenesis, ie an egg that is genetically identical to the mother that starts dividing and develops into a fetus. Therefore Jesus had to be a trans man.

[Kali]

32. nothing in the real world is black and white

including and especially BIOLOGY

[NullTuples]

41. Binaries are for the most part, a human construct to simplify a complex world.

Last edited Sun Nov 27, 2022, 01:02 AM - Edit history (2)

We group things into this bucket or that one for our convenience in thinking and communicating, and over time we forget that Nature is much more creative and messy. We see what we conceptualize and ignore that not everything fits in the bucket.

Even with computers, whose 1s and 0's are held up as the ultimate example of binary...it's still just an abstract concept, not a reality.
In the most basic example, a zero is anything below say, 0.3 volts. And a one is anything above 0.7 volts. Note the gap; the voltages are thresholds, where anything above or below can safely be assumed to be the intended logic value.

[slightlv]

33. oh, wow... you have really given me some food for thought!

I am one of those women who was a fraternal twin. I was in my Mom's uterus first! My fraternal twin was a male, he didn't make it for very long. This much I've known from Mom since I was a teenager. But now you've got me wondering if I'm carrying some of his genetic markers (as well as some of his traits). I always laughingly remarked my personality, even in the womb, was so strong, I overpowered him. But now, I wonder... if most of my assertive traits (re: male-like traits) came from his genetic nature?

I'm 66 years old, have always presented as female, use female pronouns, am a mother and grandmother, and am happy as such. But I will admit, the bi lifestyle has never been a turnoff for me, and have often said should anything happen to my husband, I'd never marry again, but would probably seek a strong female relationship, instead.

Would any of these ancestry type tests they advertise pick any of this stuff up? I've always ignored these things because I don't trust them. First, I don't trust that routines would be hardened enough to get to -me- what is intrinsically -mine- rather than someone else's. Also, I don't trust they don't turn results over to some database someplace. Since I already have a chronic autoimmune disease that has me on meds, including pain meds, I'm on databases both state and federal, no doubt. It scares the bejesus that someone, someplace, could strip me of meds I need to live.

The geek in me wonders if this type of situation has anything to do with the activation of the autoimmune gene in me, tho. I wonder if any study has been done researching this aspect. So little is known while so many of us suffer autoimmune diseases. And those of us who suffer autoimmune diseases that don't kill us (like me) are at the butt end of the science... and the compassionate nature of me understands... the painful days I have scream out in frustration, tho... I often wish this had hit me earlier. I might have made the science of biology and medicine my majors, rather than psychology, and then made a different career than the one I chose in computers and public service. So many things I'd do different if I were younger, knowing some of the things I know now! (LOL)

[Faux pas]

35. Kickin'

and very interesting. Thank you for posting

[burrowowl]

36. Yes sexuality is more complicated than Repacks

want to know.

[Marcuse]

37. A target rich environment for the GOP hate machine.

[dembotoz]

38. tonight ....on maury povich

he could wrangle an emmy out of this one

[SKKY]

39. I'm not sure Marjorie Taylor Green would be fine with this information being released...

..without her consent. It might violate her HIPAA.

[marble falls]

46. Yowsa!

[pansypoo53219]

47. when i was a kid + my mom was working st getting a med records degree she had an old book about DNA-

DNA alphabet soup. XXX, XYYY, XXXXX w/ photo of a person w/ it.

[cbabe]

48. Families can be complicated

Willie Nelson-I'm My Own Grandpa

https://m.